| CAS: | 1333377-65-3 | ||||
| 分子式: | C16H16N6 | ||||
| 分子量: | 292.34 | ||||
| 英文名称: |
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| 用途: | CHR-6494 是一种有效的 haspin 抑制剂，能够抑制组蛋白 H3T3 的磷酸化，IC50 值为 2 nM。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||||||||||||||
| C883192 | MACKLIN | CHR-6494 | ≥98% | 612元/5mg; 1154元/10mg; | 咨询 | ||||||||||||||||||||||||||||||||||||||
储存：2-8℃ | |||||||||||||||||||||||||||||||||||||||||||
| SML0648 | Sigma-Aldrich | CHR-6494 trifluoroacetate salt | ≥98% (HPLC) | 1191.25元/5 MG; | 咨询 | ||||||||||||||||||||||||||||||||||||||
产品说明 包装 5, 25 mg in glass bottle 生化/生理作用 CHR-6494 is a potent and selective Haspin (Haploid Germ Cell-Specific Nuclear Protein Kinase) inhibitor that blocks H3T3ph phosphorylation. CHR-6494 causes cell cycle arrest in G2/M and subsequent apoptosis. CHR-6494 causes an abnormal duplication of centrosomes and mitotic catastrophe in cancer cells. 基本信息
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| 372040 | Sigma-Aldrich | Haspin Kinase Inhibitor, CHR-6494-CAS 1333377-65-3-Calbiochem | 3247.82元/10 MG; | 咨询 | |||||||||||||||||||||||||||||||||||||||
产品说明 一般描述 A cell-permeable indazolylimidazopyridazinamine compound that acts as a potent and reversible inhibitor of histone kinase haspin activity (IC50 = 2 nM) with moderate selectivity over TrkA, GSK-3β, PIM1, Cdk1/B and Cdk2/A (% inhibition at 100 nM = 58, 48, 36, 34 and 33, respectively) among a panel of 27-kinases. Shown to block pH3-Thr3, with no effect on pH3-Ser10 and pH3-Ser28, cause mitotic catastrophe, upregulate BUB1 and cyclin B1 levels, and potently induce apoptosis (IC50 = 473, 500 and 752 nM in HeLa, HCT-116 and MDA-MB-231 cells, respectively). Further, efficiently blocks bFGF-induced sprouting vessel by 70% at 1 µM (chicken embryo aortic arch ring assay) and suppresses tumor growth in HCT-116 xenografted mouse model (50 mg/kg, i.p.). 包装 10 mg in Glass bottle 警告 Toxicity: Standard Handling (A) 重悬 Following reconstitution, aliqout and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 其他说明 Huertas, D., et al. 2012. Oncogene31, 1408. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息
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