CAS 1312991-76-6; 1-piperidinepropanol, α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-, ( αr,βs)-, (2z)-2-butenedioate (1:1); ro 25-6981 maleate salt

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CAS:

1312991-76-6

分子式:

C₂₆H₃₃NO₆

分子量:

455.54

中文名称:

1-piperidinepropanol, α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-, ( αr,βs)-, (2z)-2-butenedioate (1:1)

[r-(r*,s*)]-α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate salt

英文名称:

ro 25-6981 maleate salt

用途:

Ro 25-6981是包含NR2B亚基的NMDA受体选择性阻断剂，对于重组型NR1C/NR2B 和 NR1C/NR2A受体的IC50为0.009 和 52 μM。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

R883291

MACKLIN

Ro 25-6981 Maleate

≥97%

939元/5mg; 1309元/10mg;

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储存：2-8℃

SML0495

Sigma-Aldrich

Ro 25-6981 maleate salt

≥98% (HPLC)

1908.77元/5 MG; 6187.53元/25 MG;

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产品说明

应用

Ro 25-6981 maleate salt has been used as a selective N-methyl D-aspartate receptor subtype 2B (NR2B) blocker to study its effects on patch-clamp recordings of N-methyl D-aspartate receptor subtype 2A (NR2A)-containing N-methyl D-aspartate receptor (NMDAR) excitatory postsynaptic currents (EPSCs).

包装

5, 25 mg in glass bottle

生化/生理作用

Ro 25-6981 maleate salt is a potent and selective antagonist of NMDA glutamate receptors containing the NR2B subunit with IC₅₀ values of .009 μM for NR2B vs. 52 μM for NR2A subunits. Ro 25-6981 has been shown to have neuroprotectant effects and to reduce inflammatory and neuropathic pain in rodent models.

特点和优势

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式	C₂₂H₂₉NO₂ · C₄H₄O₄
分子量	455.54
MDL编号	MFCD06798375
PubChem化学物质编号	329825445
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
旋光性	[α]/D +15 to +22°, c = 1 in methanol
储存条件	desiccated
颜色	white to beige
溶解性	H₂O: 2 mg/mL (clear solution, warmed)
储存温度	2-8℃
SMILES string	OC(=O)\C=C/C(O)=O.C[C@@H](CN1CCC(CC1)Cc2ccccc2)[C@@H](O)c3ccc(O)cc3
InChI	1S/C22H29NO2.C4H4O4/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18;5-3(6)1-2-4(7)8/h2-10,17,19,22,24-25H,11-16H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t17-,22+;/m0./s1
InChI key	FYJZEHCQSUBZDY-SEELMCCHSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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