CAS 13118-10-0; 1-甲基-3-(α-环戊基扁桃酰氧基)吡咯烷盐酸盐; mandelic acid, alpha-cyclopentyl-, 1-methyl-3-pyrrolidinyl ester, hydrochloride

CAS:

13118-10-0

分子式:

C18H25NO3·HCl

分子量:

339.86

沸点:

434.6 °C at 760 mmHg

中文名称:

1-甲基-3-(α-环戊基扁桃酰氧基)吡咯烷盐酸盐

英文名称:

mandelic acid, alpha-cyclopentyl-, 1-methyl-3-pyrrolidinyl ester, hydrochloride

1-methyl-3-pyrrolidyl alpha-phenylcyclopentaneglycolate hydrochloride

ahr 376

alpha-cyclopentylmandelic acid 1-methyl-3-pyrrolidinyl ester hydrochloride

mandelic acid, alpha-cyclopentyl-,1-methyl-3-pyrrolidinyl ester, hydrochloride

1-Methyl-3-(-cyclopentylmandeloyloxy)pyrrolidine hydrochloride

1-Methyl-3-pyrrolidinyl -cyclopentylmandelate hydrochloride

生产方法:

用苯乙烯以高锰酸钾氧化，生成苯乙酮酸，然后与甲醇在硫酸参与下酯化得苯乙酮酸甲酯，将后者与环戊二烯加成（格氏反应，先以金属镁、无水乙醚、溴乙烷制成格氏试剂），得α-环戊二烯基扁桃酸甲酯，进而在活性镍作用下加压催化氢化，最后与N-甲基吡咯烷-3-醇酯交换制得该品。

用途:

胃长宁的中间体。

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