| CAS: | 130641-38-2 | |
| 分子式: | C19H20N2O3 | |
| 分子量: | 324.37 | |
| 英文名称: |
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| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||
| B795902 | MACKLIN | 宾达利 | 10mM in DMSO | 926元/1ml; | 展开 | ||||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||||
| SML2910 | Sigma-Aldrich | Bindarit | ≥98% (HPLC) | 833.87元/5 MG; 3365.56元/25 MG; | 展开 | ||||||||||||||||||||||||||||
产品说明 生化/生理作用 Bindarit is an indazolic derivative with anti-inflammatory efficacy in vitro (150-300 μM) and in animal disease models in vivo (100 mg/kg ip, 50 mg/kg po, or 0.5% in chow; rats & mice). Bindarit selectively inhibits LPS-induced CCL2/MCP-1, CCL7/MCP-3, CCL8/MCP-2 chemokines over CCL3/MIP-1α and IL-8/CXCL8 in human monocytes, while blocking CCL2, but not CCL7 or CCL8, induction in HUVECs, and preventing LPS-induced CCL2 & IL-12β/p40 by inhibiting NFκB activation in murine macrophages (BMDM & Raw 264.7). Bindarit is also reported to exhibit non-competitive inhibiory potency against human monocarboxylate transporter MCT4 (Ki = 30.2 μM) over MCT1 (<40% inhibition at 500 μM). 基本信息
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