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CAS: 130-40-5
分子式: C17H20N4NaO9P
分子量: 478.33
熔点: >300°C
中文名称: 
维生素B2磷酸钠
英文名称: 
flavin
flavin mononucleotide sodium
flavinmononucleotidesodium
riboflavin 5'-phosphate sodium
riboflavin-5'-phosphate sodium
riboflavin 5'-(dihydrogen phosphate), monosodium salt
riboflavin-5'-phosphate sodium salt dihydrate
推荐供应商
货号品牌产品名称规格包装、参考价格详情
767901MACKLIN核黄素磷酸钠10mM in Water256元/1ml;   展开
储存：-20°C
R817258MACKLIN核黄素磷酸钠USP级56元/1g;   187元/5g;   432元/25g;   1356元/100g;   3299元/500g;   展开
储存：2-8°C，避光密封干燥，保存于惰性气体中
状态：黄色到橙色结晶粉末
折射率：41 ° (C=1.5, 5mol/L HCl)
R817257MACKLIN核黄素磷酸钠93%62元/1g;   202元/5g;   594元/25g;   1824元/100g;   展开
储存：2-8°C，避光，保存于惰性气体中
状态：黄色至橙色粉末
折射率：41 ° (C=1.5, 5mol/L HCl)
R836968MACKLIN核黄素磷酸钠73~79%39元/1g;   126元/5g;   409元/25g;   1039元/100g;   3056元/500g;   展开
储存：2-8°C，避光密封干燥，保存于惰性气体中
状态：黄色到橙色粉末
折射率：41 ° (C=1.5, 5mol/L HCl)
R0249TCIRiboflavin 5'-Monophosphate Sodium Salt>85.0%(HPLC)190元/5G;   450元/25G;   展开

基本信息

纯度/分析方法>85.0%(HPLC)
分子式/分子量C17H20N4NaO9P = 478.33
外观与形状(20℃)固体
储存温度0-10℃
储存在惰性气体下存放于惰性气体之中
应避免的情况光,湿气 (吸湿),加热
Reaxys-RN4106529
Merck Index (14)8201
MDL编号MFCD00065362

技术规格

AppearanceWhite to Yellow to Orange powder to crystal
Purity(HPLC)min. 85.0 area%
Purity(Volumetric Analysis)min. 90.0 %
Specific rotation [a]20/D+37.5 to +43.4 deg(C=1.5, 5mol/L HCl)(calcd.on anh.substance)
Watermax. 10.0 %
NMRconfirm to structure

物性(参考值)

比旋光度 [α]D41° (C=1.5,5mol/L HCl)
最大吸收波长446(H2O) nm
水溶性可溶
586080J&KRiboflavin 5'-monophosphate sodium salt73.0 - 79.0%核黄素, 显著提高眼角膜生物力学特性242元/5G;   732元/25G;   2410元/100G;   展开

基本信息

分子式C17H20N4NaO9P
分子量478.33
MDL编码MFCD00065362
Beilstein4106529
存储条件Store at 2-8℃

产品描述

Riboflavin phosphate sodium significantly increases in corneal biomechanical stiffness

靶点（IC50 & Targe）

VB2

安全信息

防范说明P262
WGK3
R0630000Riboflavin Sodium PhosphateEuropean Pharmacopoeia (EP) Reference Standard1572.27元/ ;   展开

产品说明

一般描述

本产品按照现行药典要求提供和指定。所有为支持本产品而提供的信息，包括 SDS 和任何产品信息小册子，均由药典颁发机构制定和发布。 如需进一步信息和支持，请访问现行药典网站。

包装

单位数量：250 mg。随时可能改变。产品按照发行药典的规定交付。有关当前单位数量，请访问EDQM对照品目录。

注意

请参见 由EDQM提供的SDS。.

其他说明

可能适用相应的销售限制。

基本信息

经验(实验)分子式C17H20N4NaO9P
分子量478.33
Beilstein4106529
EC 号204-988-6
MDL编号MFCD00065362
PubChem化学物质编号329823989
NACRESNA.24

产品性质

生物来源synthetic
等级pharmaceutical primary standard
agencyEP
形式solid
manufacturer/tradenameEDQM
technique(s)gas chromatography (GC): suitable
liquid chromatography (LC): suitable
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES string[Na+].Cc1cc2N=C3C(=O)NC(=O)N=C3N(C[C@H](O)[C@H](O)[C@H](O)COP(O)([O-])=O)c2cc1C
InChI1S/C17H21N4O9P.Na/c1-7-3-9-10(4-8(7)2)21(15-13(18-9)16(25)20-17(26)19-15)5-11(22)14(24)12(23)6-30-31(27,28)29;/h3-4,11-12,14,22-24H,5-6H2,1-2H3,(H,20,25,26)(H2,27,28,29);/q;+1/p-1/t11-,12+,14-;/m0./s1
InChI keyOHSHFZJLPYLRIP-BMZHGHOISA-M

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable
F6750Sigma-AldrichRiboflavin 5′-monophosphate sodium salt hydrate73-79% (fluorimetric)932.65元/5 G;   1572.17元/25 G;   3987.71元/100 G;   展开

产品说明

一般描述

Riboflavin 5′-monophosphate is a derivative of riboflavin, a water-soluble vitamin.

应用

核黄素5′-单磷酸可用作底物，研究FMN磷酸水解酶的特异性和动力学特性。 FMN也可用于通过核糖开关研究基于分子感应的基因调控。
Riboflavin 5′-monophosphate sodium salt hydrate has been used in the preparation of hypo-osmolar riboflavin formulation:

  • to evaluate the riboflavin (RF) concentration and distribution in the corneal stroma
  • to study corneal resistance to enzymatic digestion
  • as a photosensitizer to evaluate the efficacy and safety of photochemical corneal stiffening using ex vivo and in vivo rabbit eye models

包装

5, 25, 100 g in glass bottle

生化/生理作用

Riboflavin 5′-monophosphate (FMN) serves as a cofactor for flavoenzymes. It is used as a prosthetic group by oxidoreductase (one and two-electron transfer) enzymes, also called flavoproteins, such as nicotinamide adenine dinucleotide (NADH) dehydrogenases, nitric oxide synthases, nitric oxide reductase, and nitrilotriacetate monooxygenases. These enzymes protect cells from oxidative stress and apoptosis. Any alteration in the levels of FMN caused due to abnormal riboflavin metabolism leads to mitochondrial dysfunction and diminished energy levels. This results in disorders related to riboflavin such as cataracts, neurodegenerative and cardiovascular diseases. FMN is associated with metabolic pathways of amino acids, fatty acids, and purines. It is involved in cellular growth and development mediated by the oxidation-reduction reaction.

质量

游离核黄素：≤6.0%
核黄素二磷酸：≤6.0%(以核黄素计)

基本信息

经验(实验)分子式C17H20N4NaO9P · xH2O
分子量478.33 (anhydrous basis)
Beilstein4106529
MDL编号MFCD00150992
eCl@ss34058005
PubChem化学物质编号24894910
NACRESNA.51

产品性质

质量水平200
测定73-79% (fluorimetric)
形式powder
溶解性water: 50 mg/mL, clear, orange
储存温度−20℃
SMILES stringO.[Na+].Cc1cc2N=C3C(=O)NC(=O)N=C3N(C[C@H](O)[C@H](O)[C@H](O)COP(O)([O-])=O)c2cc1C
InChI1S/C17H21N4O9P.Na.H2O/c1-7-3-9-10(4-8(7)2)21(15-13(18-9)16(25)20-17(26)19-15)5-11(22)14(24)12(23)6-30-31(27,28)29;;/h3-4,11-12,14,22-24H,5-6H2,1-2H3,(H,20,25,26)(H2,27,28,29);;1H2/q;+1;/p-1/t11-,12+,14-;;/m0../s1
InChI keyBHRVCJBIICJWTH-APQIITSESA-M

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)
F2253Sigma-AldrichRiboflavin 5′-monophosphate sodium salt hydratesynthetic, ≥70% (HPLC)520.95元/10 MG;   911.32元/25 MG;   2849.89元/100 MG;   展开

产品说明

应用

核黄素5′-单磷酸钠盐水合物用于：

  • 作为测定缓冲液成分，确定乳酸菌( L. lactis )细胞的发光情况
  • 作为反应混合物成分，用于一氧化氮合酶(NOS)酶活性测定
  • 高效液相色谱(HPLC),分析黄素单核苷酸(FMN)环化酶产物
  • 萤火虫荧光素酶的荧光素酶测定

包装

100 mg in glass bottle
10, 25 mg in glass insert

生化/生理作用

核黄素5′-单磷酸(FMN)是一种核黄素衍生物，主要用作氧化还原反应1到2个电子转移的辅基。它是还原型烟酰胺腺嘌呤二核苷酸(NADH)脱氢酶、一氧化氮合酶和氨三乙酸单加氧酶等酶的辅因子。核黄素5′-单磷酸可用作底物，研究FMN磷酸水解酶的特异性和动力学特性，也可以通过核糖开关研究基于分子感应的基因调控。

基本信息

经验(实验)分子式C17H20N4NaO9P · xH2O
分子量478.33 (anhydrous basis)
Beilstein4106529
MDL编号MFCD00150992
eCl@ss34058005
PubChem化学物质编号24894817
NACRESNA.51

产品性质

质量水平200
生物来源synthetic
测定≥70% (HPLC)
形式powder
杂质≤0.3% Riboflavin
溶解性water: 50 mg/mL
储存温度−20℃
SMILES stringO.[Na+].Cc1cc2N=C3C(=O)NC(=O)N=C3N(C[C@H](O)[C@H](O)[C@H](O)COP(O)([O-])=O)c2cc1C
InChI1S/C17H21N4O9P.Na.H2O/c1-7-3-9-10(4-8(7)2)21(15-13(18-9)16(25)20-17(26)19-15)5-11(22)14(24)12(23)6-30-31(27,28)29;;/h3-4,11-12,14,22-24H,5-6H2,1-2H3,(H,20,25,26)(H2,27,28,29);;1H2/q;+1;/p-1/t11-,12+,14-;;/m0../s1
InChI keyBHRVCJBIICJWTH-APQIITSESA-M

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)
F1392Sigma-AldrichRiboflavin 5′-monophosphate sodium salt hydratesuitable for electrophoresis, suitable for acrylamide photopolymerization, ≥70%, powder1145.82元/25 MG;   展开

产品说明

应用

核黄素5′-单磷酸盐钠盐水合物或FMN适用于：

  • 研究其对苯并[a]芘7,8-二醇9,10-环氧化物(一种苯并[a]芘的致癌代谢产物)的抑制机理
  • 在研究中联用黄素腺嘌呤二核苷酸，用于将吡哆胺氧化成为吡哆醛的酶的再激活
  • 研究肠道细菌对聚合偶氮和硝基染料的还原作用
  • 研究FMN对根癌农杆菌(Agrobacterium tumefaciens)细胞质中的铁载体还原酶活性的影响

包装

25 mg in poly bottle

生化/生理作用

FMN是由核黄素(维生素B2)合成的辅酶。它是电子传递链复合物I的组分。含有FMN的酶称为黄素酶，参与氧化还原机制。
FMN适合用作聚丙烯酰胺凝胶电泳(PAGE)的光聚合试剂，可在光存在下在水溶液中形成自由基。FMN光致分解为无色核黄素。在无氧情况下不会形成自由基，而痕量的氧气可使无色核黄素在自由基生成的情况下再氧化。通常加入催化剂四甲基乙二胺(TEMED)或3-二甲基氨基丙腈(DMAPN)，加速自由基的形成。自由基会引发丙烯酰胺和双丙烯酰胺聚合形成凝胶基质，后者可用于筛分大分子。FMN通常用于积层凝胶中进行非变性PAGE，因为天然蛋白对过硫酸铵中的过硫酸根离子敏感。FMN相对于过硫酸铵的另一个优点是它在凝胶光照后才开始聚合。
Riboflavin 5′-monophosphate or Flavin mononucleotide (FMN) serves as a prosthetic group for flavoenzymes. It is a part of the mitochondrial respiratory chain complex I and acts as a redox carrier. FMN is unstable in alkaline solution and is highly stable at pH 6.

基本信息

经验(实验)分子式C17H20N4NaO9P · xH2O
分子量478.33 (anhydrous basis)
Beilstein4106529
EC 号204-988-6
MDL编号MFCD00150992
PubChem化学物质编号24894764
NACRESNA.51

产品性质

质量水平100
测定≥70%
形式powder
旋光性[α]20/D +37 to +42°, c = 1.5 in 5 M HCl(lit.)
technique(s)electrophoresis: suitable
溶解性H2O: soluble 50 mg/mL, clear, orange
ε (extinction coefficient)12.5 at 445 nm at 1 mM
适用性suitable for acrylamide photopolymerization
异质活性Protease, none detected
储存温度−20℃
SMILES stringO.[Na+].Cc1cc2N=C3C(=O)NC(=O)N=C3N(C[C@H](O)[C@H](O)[C@H](O)COP(O)([O-])=O)c2cc1C
InChI1S/C17H21N4O9P.Na.H2O/c1-7-3-9-10(4-8(7)2)21(15-13(18-9)16(25)20-17(26)19-15)5-11(22)14(24)12(23)6-30-31(27,28)29;;/h3-4,11-12,14,22-24H,5-6H2,1-2H3,(H,20,25,26)(H2,27,28,29);;1H2/q;+1;/p-1/t11-,12+,14-;;/m0../s1
InChI keyBHRVCJBIICJWTH-APQIITSESA-M

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)
77623Sigma-AldrichRiboflavin 5′-monophosphate sodium salttested according to Ph. Eur.2348.16元/50 G;   展开

产品说明

一般描述

Riboflavin 5′-monophosphate is also known as flavin mononucleotide (FMN). FMN is a water-soluble micronutrient. It is enzymatically produced from riboflavin (RF). Riboflavin 5′-monophosphate is one of the constituent of enzyme cofactor flavin-adenine dinucleotide.

应用

Riboflavin 5′-monophosphate sodium salt was used as water-soluble model drug in a combined conventional inkjet printing technology with flexographic printing for the fabrication of drug delivery systems. It may be employed as initiator for the photo-initiated polymerization of acrylamide. It may be employed in chronoamperometric assay for vanadium ions.

生化/生理作用

Riboflavin 5′-monophosphate or flavin mononucleotide (FMN) possesses fluorescence, photosensitivity and redox activities.

基本信息

经验(实验)分子式C17H20N4NaO9P
分子量478.33
Beilstein4106529
EC 号204-988-6
MDL编号MFCD00065362
PubChem化学物质编号329767821
NACRESNA.26

产品性质

质量水平200
生物来源synthetic
agencyUSP/NF
tested according to Ph. Eur.
测定73 - 79% dry basis (RIBOFLAVIN)
形式powder
溶解性water: soluble 100 g/L at 20 ℃
application(s)pharmaceutical (small molecule)
储存温度2-8℃
SMILES string[Na+].Cc1cc2N=C3C(=O)NC(=O)N=C3N(C[C@H](O)[C@H](O)[C@H](O)COP(O)([O-])=O)c2cc1C
InChI1S/C17H21N4O9P.Na/c1-7-3-9-10(4-8(7)2)21(15-13(18-9)16(25)20-17(26)19-15)5-11(22)14(24)12(23)6-30-31(27,28)29;/h3-4,11-12,14,22-24H,5-6H2,1-2H3,(H,20,25,26)(H2,27,28,29);/q;+1/p-1/t11-,12+,14-;/m0./s1
InChI keyOHSHFZJLPYLRIP-BMZHGHOISA-M

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)
BP459Riboflavin Sodium PhosphateBritish Pharmacopoeia (BP) Reference Standard382.26元/50 MG;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Riboflavin sodium phosphate is a supplement form of riboflavin (vitamin B2), which is necessary for human nutrition, and growth. It finds potential applications in biological redox reactions and is found in several foodstuffs, energy drinks, and vitamin formulations.

应用

Riboflavin sodium phosphate may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography.

包装

Unit quantity: 50 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C17H20N4NaO9P
分子量478.33
Beilstein4106529
EC 号204-988-6
MDL编号MFCD00065362
NACRESNA.24

产品性质

等级pharmaceutical primary standard
agencyBP
形式solid
质量British Pharmacopoeia (BP) Reference Standard
manufacturer/tradenameBP
technique(s)gas chromatography (GC): suitable
liquid chromatography (LC): suitable
mp240-245 ℃
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES string[Na+].Cc1cc2N=C3C(=O)NC(=O)N=C3N(C[C@H](O)[C@H](O)[C@H](O)COP(O)([O-])=O)c2cc1C
InChI1S/C17H21N4O9P.Na/c1-7-3-9-10(4-8(7)2)21(15-13(18-9)16(25)20-17(26)19-15)5-11(22)14(24)12(23)6-30-31(27,28)29;/h3-4,11-12,14,22-24H,5-6H2,1-2H3,(H,20,25,26)(H2,27,28,29);/q;+1/p-1/t11-,12+,14-;/m0./s1
InChI keyOHSHFZJLPYLRIP-BMZHGHOISA-M

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable
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