| CAS: | 1290541-46-6 | ||
| 分子式: | C22H17N3O | ||
| 分子量: | 339.39 | ||
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| 用途: | B02是一种人源RAD51小分子抑制剂，IC50为27.4 μM，对大肠杆菌中的同系物RecA没有抑制作用（IC50>250 μM）。B02是人源RAD51重组酶的特异性抑制剂，在人胚胎肾细胞和乳腺癌细胞中，抑制同源重组修复，增强它们对DNA损伤试剂的敏感性。在MM细胞中，B02也能增强DNA损伤和decitabine诱导的凋亡反应[1]。B02对RAD51具有高度特异性，在浓度范围0-200 μM时，对RAD54没有显著抑制作用[2]。B02在人类和小鼠细胞中具有生物活性，在人类胚胎肾细胞（HEK）中，B02破坏RAD51在响应DNA损伤时的集落形成、抑制DSB修复和依赖于DSB的同源重组。B02还可增强癌细胞对化疗中的DNA损伤试剂的敏感性[3]。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||||||||||||
| B872535 | MACKLIN | B02 | 99% | 215元/5mg; 1073元/25mg; | 展开 | ||||||||||||||||||||||||||||||||||||||
储存：-20℃ 状态：白色到暗棕色粉末 | |||||||||||||||||||||||||||||||||||||||||||
| B794931 | MACKLIN | B02 | 10mM in DMSO | 734元/1ml; | 展开 | ||||||||||||||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||||||||||||||
| SML0364 | Sigma-Aldrich | RAD51 Inhibitor B02 | ≥98% (HPLC) | 1843.44元/5 MG; 5967.79元/25 MG; | 展开 | ||||||||||||||||||||||||||||||||||||||
产品说明 应用 RAD51 抑制剂B02已被用于：
包装 5, 25 mg in glass bottle 生化/生理作用 B02 (3-(苯甲基)-2-[(1E)-2-(3-吡啶基)乙烯基]-4(3H)-喹唑啉酮是一种吡啶基乙烯基喹唑啉酮化合物，可以穿透细胞。B02抑制人RAD51重组酶及之后核线的形成。它可以中止癌细胞中的同源重组(HR)修复活动。B02促进多发性骨髓瘤中的细胞凋亡，同时也是敏化多柔比星的关键。 基本信息
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| 553525 | Sigma-Aldrich | RAD51 Inhibitor, B02-CAS 1290541-46-6-Calbiochem | The RAD51 Inhibitor, B02 controls the biological activity of RAD51. This small molecule/inhibitor is primarily used for Cell Structure applications. | 2287.32元/25 MG; | 展开 | ||||||||||||||||||||||||||||||||||||||
产品说明 一般描述 A cell-permeable pyridinylvinyl-quinazolinone compound that is shown to specifically inhibit human RAD51 (IC50 = 27.4 µM). Does not affect RecA even at much higher concentration (~250 µM). Directly interacts with RAD51 (Kd = 5.6 µM), and disrupts its binding to DNA and nucleoprotein filament formation. Blocks double-strand break-induced homologous recombination and enhances sensitivity of cells to Cisplatin (Cat. No. 232120) and Mitomycin C (Cat. No. 47589), (Cat. No. 475820). Diminishes co-aggregate formation between RAD51-ssDNA filament and dsDNA. RAD51-Stimulatory Compound-1, RS-1 (Cat. No. 553510) is also available. 包装 25 mg in Glass bottle 警告 Toxicity: Regulatory Review (Z) 重悬 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 其他说明 Huang, F., et al. 2012. J. Med. Chem.55, 3031. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息
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