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CAS: 128-53-0
分子式: C6H7NO2
分子量: 125.12
沸点: 210℃
熔点: 41-45℃
中文名称: 
N-乙基顺丁烯二酰亚胺
1-乙基-1H-吡咯-2,5-二酮
N-乙基失水苹果酰亚胺
N-乙基马来酰亚胺
英文名称: 
1H-Pyrrole-2,5-dione,1-ethyl-
ethvlmaleimide
n-ethvlmaleimide
N-Ethyl maleimide
5-dione, 1-ethyl-1H-Pyrrole-2
1-ethyl-1h-pyrrole-5-dione
ethylmaleimide
maleic acid n-ethylimide
n-ethyl-maleimid
n-ethylmaleimide
usaf b-121
展开更多英文名
推荐供应商
货号品牌产品名称规格包装、参考价格详情
N796179MACKLIN|N|-乙基顺丁烯二酰亚胺10mM in DMSO158元/1ml;   展开
储存:-20°C
状态:液体
N808610MACKLIN|N|-乙基顺丁烯二酰亚胺超纯级,99.0%109元/1g;   245元/5g;   820元/25g;   2489元/100g;   8920元/500g;   展开
储存:2~8°C
状态:白色到灰白色粉末,晶体和/或块状
N808609MACKLIN|N|-乙基顺丁烯二酰亚胺98%40元/1g;   130元/5g;   428元/25g;   1609元/100g;   7389元/500g;   展开
储存:2~8°C
状态:白色到黄色粉末或晶体
E0136TCIN-Ethylmaleimide>98.0%(HPLC)(N)195元/1G;   410元/5G;   1145元/25G;   展开

基本信息

纯度/分析方法>98.0%(HPLC)(N)
分子式/分子量C6H7NO2 = 125.13
外观与形状(20℃)固体
储存温度0-10℃
储存在惰性气体下存放于惰性气体之中
应避免的情况光,空气,加热
Reaxys-RN112448
PubChem物质ID87569433
SDBS (AIST Spectral DB)1560
Merck Index (14)3822
MDL编号MFCD00005509

技术规格

AppearanceWhite powder to crystal
Purity(HPLC)min. 98.0 area%
Purity(with Total Nitrogen)min. 98.0 %
Melting point44.0 to 47.0 ℃
Solubility in Wateralmost transparency

物性(参考值)

熔点46 ℃
沸点210 ℃
水溶性可溶

安全信息

图形或危害标志
信号词危险
危险性说明H300 : 吞咽致命。
H311 : 皮肤接触会中毒。
H314 : 造成严重皮肤灼伤和眼损伤。
H317 : 可能造成皮肤过敏反应。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P272 : 受沾染的工作服不得带出工作场地。
P260 : 不要吸入粉尘或烟雾。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P361 + P364 : 立即脱掉所有沾染的衣服,清洗后方可重新使用。
P303 + P361 + P353 : 如皮肤(或头发)沾染:立即脱掉所有沾污的衣物。用水清洗皮肤/淋浴。
P333 + P313 : 如发生皮肤刺激或皮疹:求医/就诊。
P301 + P330 + P331 : 如误吞咽:漱口。不要诱导呕吐。
P301 + P310 + P330 : 如误吞咽:立即呼叫急救中心/医生。漱口。
P304 + P340 + P310 : 如误吸入:将人转移到空气新鲜处,保持呼吸舒适体位。立即呼叫急救中心/医生。
P305 + P351 + P338 + P310 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。立即呼叫急救中心/医生。
P405 : 存放处须加锁。

相关法规

RTECS#UX9625000

运输信息

UN编号UN2928
类别6.1 / 8
包装类别 II
监管条件代码(*)
466446J&KN-Ethylmaleimide99%352元/5G;   912元/25G;   展开

基本信息

分子式C6H7NO2
分子量125.13
熔点43-46
沸点210
闪点73
MDL编码MFCD00005509
Beilstein112448
Merck14,3822
EINECS 编号204-892-4
存储条件Store at 2-8℃

安全信息

图形或危害标志
提示语Danger
危险说明H300
H311
H314
H317
防范说明P264
P280
P301+P310
P305+P351+P338
P310
UN号码2928
危险分类6.1
次要危险性8
包装等级II
WGK3
RTECSUX9625000
L00355Alfa AesarN-Ethylmaleimide98+%1729元/10g;   4585元/50g;   展开

备注
Light sensitive. Store in cool place. Incompatible with strong oxidizing agents, strong acids and strong bases.

基本信息

MDL
MFCD00005509

EINECS
204-892-4

分子式
C6H7NO2

分子量
125.13

熔点
43-46°

沸点
209-211°

闪点
73°(163°F)

灵敏度
Light Sensitive. Ambient temperatures.

形态
Crystalline powder

溶解性
Soluble in ethanol, water, chloroform, methanol and toluene.

Beilstein
112448

Merck
14,3822

GHS危害和防范说明

GHS符号

Hazard Statements
H300-H311-H314-H318-H317
Fatal if swallowed.Toxic in contact with skin.Causes severe skin burns and eye damage.Causes serious eye damage.May cause an allergic skin reaction.

Precautionary Statements
P260h-P301+P310a-P303+P361+P353-P305+P351+P338-P405-P501a
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险等级
6.1

包装组
II

危险类别
21-28-34-43
Harmful in contact with skin.Very toxic if swallowed.Causes burns.May cause sensitization by skin contact.

安全等级
20-26-28-36/37/39-45-60
When using do not eat or drink.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer).Wear suitable protective clothing, gloves and eye/face protection.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).This material and its container must be disposed of as hazardous waste

欧盟危险品标志

RTECS
UX9625000

TSCA

040526Alfa AesarN-Ethylmaleimide99+%276元/1g;   599元/5g;   2521元/25g;   展开

应用
N-Ethylmaleimide is a protein thiol modifier which inhibits apoptotic DNA fragmentation. It is a sulfhydryl reagent and finds application in experimental biochemical studies as well as in enzymology. It is involved in the modification of cysteine residues in proteins and peptides. It acts as a Michael acceptor and reacts with nucelophiles like thiols. It is employed in the inhibition of Mg2+ dependent internucleosomal DNA fragmentation.

备注
Light sensitive. Store in cool place. Incompatible with strong oxidizing agents, strong acids and strong bases.

基本信息

MDL
MFCD00005509

EINECS
204-892-4

分子式
C6H7NO2

分子量
125.13

熔点
43-46°

沸点
209-211°

闪点
73°(163°F)

灵敏度
Light Sensitive. Ambient temperatures.

形态
Crystalline

溶解性
Soluble in ethanol, water, chloroform, methanol and toluene.

Beilstein
112448

Merck
14,3822

GHS危害和防范说明

GHS符号

Hazard Statements
H300-H311-H314-H318-H317
Fatal if swallowed.Toxic in contact with skin.Causes severe skin burns and eye damage.Causes serious eye damage.May cause an allergic skin reaction.

Precautionary Statements
P260h-P301+P310a-P303+P361+P353-P305+P351+P338-P405-P501a
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险等级
6.1

包装组
II

危险类别
21-28-34-43
Harmful in contact with skin.Very toxic if swallowed.Causes burns.May cause sensitization by skin contact.

安全等级
20-26-28-36/37/39-45-60
When using do not eat or drink.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer).Wear suitable protective clothing, gloves and eye/face protection.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).This material and its container must be disposed of as hazardous waste

欧盟危险品标志

RTECS
UX9625000

TSCA

C15610Alfa AesarN-Ethylmaleimide99+%775元/5g;   1486元/10g;   5397元/50g;   20210元/250g;   展开

基本信息

Ref#
15610

MDL
5509

分子式
C6 H7 N O2

分子量
125.13

闪点
73

形态
Crystalline

安全信息

危险等级
6.1

包装组
II

O2829-25Alfa AesarN-ETHYLMALEIMIDE R 25G2619元/25g;   展开

基本信息

Ref#
F51593

安全信息

危险等级
6.1

包装组
II

E3876Sigma-AldrichN-Ethylmaleimidecrystalline, ≥98% (HPLC)794.73元/5 G;   1633.45元/25 G;   5532.81元/100 G;   展开

产品说明

包装

5, 25, 100 g in glass bottle

应用

用于共价修饰蛋白质的半胱氨酸残基的试剂。

生化/生理作用

增强来自交感神经元的原生 M 通道的电流,并作为 KCNQ2、KCNQ4 和 KCNQ5 通道的开放剂。
使 NADP 依赖性异柠檬酸脱氢酶和许多核酸内切酶失活的巯基烷化剂。

制备说明

NEM 以 50mg/ml 的浓度溶于乙醇可得到透明的溶液。NEM 可溶于水(在 4ml 水中的溶解量 >50mg);然而,水溶液却不稳定。水解速率为假一级,并显著依赖于 pH 值。

基本信息

经验(实验)分子式C6H7NO2
分子量125.13
Beilstein112448
EC 号204-892-4
MDL编号MFCD00005509
PubChem化学物质编号24278420
NACRESNA.21

产品性质

质量水平200
生物来源synthetic (organic)
测定≥98% (HPLC)
形式crystalline
bp210 ℃ (lit.)
mp43-46 ℃ (lit.)
溶解性ethanol: 50 mg/mL, clear to slightly hazy, colorless to faint yellow or tan
储存温度2-8℃
SMILES stringCCN1C(=O)C=CC1=O
InChI1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3
InChI keyHDFGOPSGAURCEO-UHFFFAOYSA-N
Gene Informationhuman ... KCNQ2(3785), KCNQ4(9132), KCNQ5(56479), SLC6A3(6531), SLC6A4(6532)

安全信息

象形图GHS05GHS06
警示用语:Danger
危险声明H300 - H311 - H314 - H317
预防措施声明P260 - P270 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
危险分类Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1
储存分类代码6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3
闪点(F)163.2 °F
闪点(C)72.9 ℃
个人防护装备Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
04259Sigma-AldrichN-EthylmaleimideBioUltra, ≥99.0% (HPLC)1867.79元/5G;   7435.82元/25G;   展开

产品说明

应用

N-乙基马来酰亚胺(NEM)用于:

  • 制备NEM修饰的肌球蛋白珠
  • 封闭样品中未修饰的游离硫醇
  • 作为IP裂解/清洗缓冲液的补充剂,以用于 体外 SUMOylation分析

用于共价修饰蛋白质的半胱氨酸残基的试剂。

生化/生理作用

增强来自交感神经元的原生 M 通道的电流,并作为 KCNQ2、KCNQ4 和 KCNQ5 通道的开放剂。
使 NADP 依赖性异柠檬酸脱氢酶和许多核酸内切酶失活的巯基烷化剂。

基本信息

经验(实验)分子式C6H7NO2
分子量125.13
Beilstein112448
EC 号204-892-4
MDL编号MFCD00005509
PubChem化学物质编号329747899
NACRESNA.26

产品性质

产品线BioUltra
质量水平200
测定≥99.0% (HPLC)
杂质 insoluble matter, passes filter test
灼烧残渣≤0.05%
bp210 ℃ (lit.)
mp43-46 ℃ (lit.)
44-47 ℃
溶解性methanol: 1 M at 20 ℃, clear, colorless
痕量阴离子chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤100 mg/kg
痕量阳离子Al: ≤5 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg
吸光度cut-off at 382 nm in methanol at 1 M
储存温度2-8℃
SMILES stringCCN1C(=O)C=CC1=O
InChI1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3
InChI keyHDFGOPSGAURCEO-UHFFFAOYSA-N
Gene Informationhuman ... SLC6A3(6531), SLC6A4(6532)

安全信息

象形图GHS05GHS06
警示用语:Danger
危险声明H300 - H311 - H314 - H317
预防措施声明P260 - P280 - P301 + P310 + P330 - P303 + P361 + P353 - P305 + P351 + P338 + P310
危险分类Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1
储存分类代码6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3
闪点(F)163.2 °F
闪点(C)72.9 ℃
个人防护装备Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
E1271Sigma-AldrichN-EthylmaleimideBioXtra, ≥98% (HPLC)829.94元/1 G;   1679.24元/5 G;   展开

产品说明

包装

1, 5 g in glass bottle

应用

用于共价修饰蛋白质的半胱氨酸残基的试剂。

生化/生理作用

增强来自交感神经元的原生 M 通道的电流,并作为 KCNQ2、KCNQ4 和 KCNQ5 通道的开放剂。
使 NADP 依赖性异柠檬酸脱氢酶和许多核酸内切酶失活的巯基烷化剂。

基本信息

经验(实验)分子式C6H7NO2
分子量125.13
Beilstein112448
EC 号204-892-4
MDL编号MFCD00005509
PubChem化学物质编号24894398
NACRESNA.21

产品性质

质量水平200
产品线BioXtra
测定≥98% (HPLC)
杂质≤0.001% Phosphorus (P)
≤0.1% Insoluble matter
灼烧残渣≤0.1%
bp210 ℃ (lit.)
mp43-46 ℃ (lit.)
溶解性95% ethanol: 50 mg/mL, clear to slightly hazy (colorless to faint yellow)
痕量阴离子chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%
痕量阳离子Al: ≤0.0005%
Ca: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
Na: ≤0.005%
Pb: ≤0.001%
Zn: ≤0.0005%
储存温度2-8℃
SMILES stringCCN1C(=O)C=CC1=O
InChI1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3
InChI keyHDFGOPSGAURCEO-UHFFFAOYSA-N
Gene Informationhuman ... SLC6A3(6531), SLC6A4(6532)

安全信息

象形图GHS05GHS06
警示用语:Danger
危险声明H300 - H311 - H314 - H317
预防措施声明P260 - P270 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
危险分类Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1
储存分类代码6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3
个人防护装备Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
04260Sigma-AldrichN-Ethylmaleimidepurum p.a., ≥99.0% (HPLC)1155.92元/5G-F;   2965.11元/25G-F;   展开

产品说明

应用

N-乙基马来酰亚胺已被用于测量与血浆蛋白结合的低分子量硫醇。
用于共价修饰蛋白质的半胱氨酸残基的试剂。

生化/生理作用

增强来自交感神经元的原生 M 通道的电流,并作为 KCNQ2、KCNQ4 和 KCNQ5 通道的开放剂。
使 NADP 依赖性异柠檬酸脱氢酶和许多核酸内切酶失活的巯基烷化剂。

基本信息

经验(实验)分子式C6H7NO2
分子量125.13
Beilstein112448
EC 号204-892-4
MDL编号MFCD00005509
PubChem化学物质编号329747901
NACRESNA.26

产品性质

质量水平200
等级purum p.a.
测定≥99.0% (HPLC)
灼烧残渣≤0.05%
bp210 ℃ (lit.)
mp43-46 ℃ (lit.)
43-46 ℃
痕量阴离子chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤100 mg/kg
痕量阳离子Ca: ≤50 mg/kg
Cd: ≤50 mg/kg
Co: ≤50 mg/kg
Cu: ≤50 mg/kg
Fe: ≤50 mg/kg
K: ≤100 mg/kg
Na: ≤100 mg/kg
Ni: ≤50 mg/kg
Pb: ≤50 mg/kg
Zn: ≤50 mg/kg
储存温度2-8℃
SMILES stringCCN1C(=O)C=CC1=O
InChI1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3
InChI keyHDFGOPSGAURCEO-UHFFFAOYSA-N
Gene Informationhuman ... SLC6A3(6531), SLC6A4(6532)

安全信息

象形图GHS05GHS06
警示用语:Danger
危险声明H300 - H311 - H314 - H317
预防措施声明P260 - P270 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
危险分类Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1
储存分类代码6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3
闪点(F)163.2 °F
闪点(C)72.9 ℃
个人防护装备Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
937101AmethystN-Ethylmaleimide99%, 试剂级58元/1G;   204元/5G;   754元/25G;   2345元/100G;   展开

基本信息

分子式C6H7NO2
分子量125.13
熔点41-45
沸点210
闪点73
MDL编码MFCD00005509
Beilstein112448
Merck14,3822
EINECS 编号204-892-4
存储条件Store at 2-8℃

安全信息

图形或危害标志
提示语Danger
危险说明H300
H311
H314
H317
防范说明P264
P280
P301+P310
P305+P351+P338
P310
UN号码2928
危险分类6.1
次要危险性8
包装等级II
WGK3
RTECSUX9625000
047870FluorochemN-Ethylmaleimide98%242元/1g;   792元/5g;   1496元/10g;   2970元/25g;   展开

基本信息

CAS Number128-53-0
MDL NumberMFCD00005509
Boiling Point210 ℃
Melting Point43 - 46 ℃

安全信息

图形或危害标志
危险性说明 H300: Fatal if swallowed.
H311: Toxic in contact with skin.
H314: Causes severe skin burns and eye damage.
H317: May cause an allergic skin reaction.
防范说明 P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear .
P301 + P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P330 + P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P303 + P361 + P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P310: Immediately call a POISON CENTER or doctor/physician.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P322: Specific measures (see . on this label).
P330: Rinse mouth.
P333 + P313: If skin irritation or rash occurs: Get medical advice/attention.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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