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CAS: 128-08-5
分子式: C4H4BrNO2
分子量: 177.98
熔点: 175-178℃
中文名称: 
N-溴代丁二酰亚胺
N-溴代琥珀酰亚胺
溴丁二酰亚胺
英文名称: 
5-Pyrrolidinedione, 1-bromo-2
1-bromo-5-pyrrolidinedione
n-bromosuccinimide
Succinbromimide
1-Bromo-2,5-phrrolidinedione
NBS
2,5-Pyrrolidinedione,1-bromo-
N-Brom-succinimid
N-Bromo butanediimide
性质描述: 白色至乳白色细粒结晶，微有溴气味。密度2.098g/cm3，熔点180-183℃（分解），在173.5℃时稍分解。溶于四氯化碳。活性溴的最小含量44.5%。
生产方法: 1.由丁二酰亚胺溴化而得。将丁二酰亚胺磨细投入反应锅，加入碎冰和氢氧化钠溶液，搅拌溶解。在剧烈搅拌和冷却的情况下，加入溴和四氯化碳的混合液，搅拌2分钟后迅速过滤。用冰水充分洗涤至洗涤无色，再用少量乙醇洗涤，干燥得成品。2.由丁二酸与氨合成丁二酸铵，再加热脱水生成琥珀酰亚胺，然后再溴化、精制得成品。
用途: 有机合成原料，用于调节低能溴化反应，也用于生产橡胶助剂和医药品。可合成溴乙腈医药。农药工业用于合成噻菌灵，还可用作水果保鲜剂以及防腐、防霉剂等。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
N802275MACKLINN-溴代丁二酰亚胺试剂级, 99.00%44元/100g;   100元/500g;   165元/1kg;   750元/5kg;   3150元/25kg;   1150元/12X500g;   展开
储存：室温
状态：白色到黄色晶体,颗粒,粉末,块状
B0656TCIN-Bromosuccinimide>98.0%(T)195元/25G;   350元/100G;   935元/500G;   展开

基本信息

纯度/分析方法>98.0%(T)
分子式/分子量C4H4BrNO2 = 177.99
外观与形状(20℃)固体
储存温度0-10℃
储存在惰性气体下存放于惰性气体之中
应避免的情况光,湿气 (分解),加热
Reaxys-RN113916
PubChem物质ID87563662
SDBS (AIST Spectral DB)1944
Merck Index (14)1438
MDL编号MFCD00005510

技术规格

AppearanceWhite to Orange to Green powder to crystal
Purity(Iodometric Titration)min. 98.0 %

物性(参考值)

熔点176 ℃(dec.)
沸点339 ℃
水溶性微溶
在水中的溶解度14.7 g/l   25 ℃
溶解性(可溶于)丙酮
溶解度(极微溶)乙醚

安全信息

图形或危害标志
信号词危险
危险性说明H302 : 吞咽有害。
H314 : 造成严重皮肤灼伤和眼损伤。
H290 : 可能腐蚀金属。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P260 : 不要吸入粉尘或烟雾。
P270 : 使用本产品时不要进食、饮水或吸烟。
P234 : 只能在原容器中存放。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P390 : 吸收溢出物，防止材料损坏。
P303 + P361 + P353 : 如皮肤(或头发)沾染：立即脱掉所有沾污的衣物。用水清洗皮肤/淋浴。
P301 + P330 + P331 : 如误吞咽：漱口。不要诱导呕吐。
P363 : 沾染的衣服清洗后方可重新使用。
P301 + P312 + P330 : 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口。
P304 + P340 + P310 : 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。立即呼叫急救中心/医生。
P305 + P351 + P338 + P310 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。立即呼叫急救中心/医生。
P406 : 贮存于抗腐蚀/带抗腐蚀衬里的容器中。
P405 : 存放处须加锁。

运输信息

UN编号UN3261
类别8
包装类别 III
监管条件代码(*)
272873J&KN-Bromosuccinimide99%103元/100G;   358元/500G;   629元/1kg;   展开

基本信息

分子式C4H4BrNO2
分子量177.99
熔点175-178
MDL编码MFCD00005510
EINECS 编号204-877-2
存储条件Store at 2-8℃

安全信息

图形或危害标志
提示语Danger
危险说明H302
H314
防范说明P280
P305+P351+P338
P310
UN号码3261
危险分类8
包装等级II
WGK3
TSCA是
970698J&KN-Bromosuccinimide99%, 水分:≤1.0%442.1元/5G;   展开

基本信息

分子式C4H4BrNO2
分子量177.99
熔点175-178
MDL编码MFCD00005510
EINECS 编号204-877-2
存储条件Store at 2-8℃

安全信息

图形或危害标志
提示语Danger
危险说明H302
H314
防范说明P280
P305+P351+P338
P310
UN号码3261
危险分类8
包装等级II
WGK3
TSCA是
A15922Alfa AesarN-Bromosuccinimide99%643元/250g;   2017元/1000g;   8160元/5000g;   展开

应用
N-Bromosuccinimide is a chemical reagent used in electrophilic additions and radical substitution reactions in synthetic organic chemistry. In Wohl-Ziegler reaction, it is involved in allylic and benzylic bromination reaction. It is also used in the alfa-bromination of carbonyl derivatives. In the Hofmann rearrangement, it is used in the presence of a strong base, such as 1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) reacts with primary amides to produce a carbamate. It oxidizes silyl ethers to aldehydes in the presence of azobisisobutyronitrile. It is also used for the modification of ribosomal sulfhydryl groups.

备注
Moisture and light sensitive. Incompatible with strong oxidizing agents, strong acids, strong bases, iron, iron salts, halogenated hydrocarbons, amines and metals. Store in a cool place.

基本信息

MDL
MFCD00005510

EINECS
204-877-2

分子式
C4H4BrNO2

分子量
177.99

熔点
175-180° dec.

密度
2.098

灵敏度
Light Sensitive. Ambient temperatures.

形态
Powder

溶解性
Soluble in acetone, tetrahydrofuran, dimethyl formamide, dimethyl sulfoxide and acetonitrile. Slightly soluble in water and acetic acid. Insoluble in ether, hexane and carbon tetrachloride.

Beilstein
113916

Merck
14,1438

GHS危害和防范说明

GHS符号

Hazard Statements
H302-H314-H318
Harmful if swallowed.Causes severe skin burns and eye damage.Causes serious eye damage.

Precautionary Statements
P260h-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险等级
8

包装组
II

危险类别
22-34
Harmful if swallowed.Causes burns.

安全等级
20-26-36/37/39-45-60
When using do not eat or drink.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing, gloves and eye/face protection.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).This material and its container must be disposed of as hazardous waste

欧盟危险品标志

TSCA
是

C10745Alfa AesarN-Bromosuccinimide99%636元/10g;   695元/100g;   1246元/500g;   2314元/1kg;   8635元/5kg;   展开

基本信息

Ref#
10745

MDL
5510

分子式
C4 H4 Br N O2

分子量
177.99

闪点
180

形态
White to pale yellow/cream powder

安全信息

危险等级
8

包装组
III

B81255Sigma-AldrichN-BromosuccinimideReagentPlus®, 99%436.68元/100 G;   579.06元/5 G;   683.54元/250 G;   1120.16元/500 G;   1281.99元/1 KG;   4855.99元/5 KG;   展开

产品说明

包装

100, 250, 500 g in poly bottle
5 g in glass bottle
1, 5 kg in poly bottle

应用

通用溴化剂。在 AIBN 存在的条件下，可将硅基醚氧化为醛。
多功能溴化剂。用于色氨酸的氧化反应，但酪氨酸、组氨酸和甲硫氨酸残基被氧化的程度可能较低。也可用于核糖体巯基的改性。

法律信息

ReagentPlus is a registered trademark of sigma-aldrich Co. LLC

基本信息

经验(实验)分子式C4H4BrNO2
分子量177.98
Beilstein113916
EC 号204-877-2
MDL编号MFCD00005510
PubChem化学物质编号57653959
NACRESNA.22

产品性质

质量水平200
产品线ReagentPlus®
测定99%
mp175-180 ℃ (dec.) (lit.)
application(s)peptide synthesis
储存温度2-8℃
SMILES stringBrN1C(=O)CCC1=O
InChI1S/C4H4BrNO2/c5-6-3(7)1-2-4(6)8/h1-2H2
InChI keyPCLIMKBDDGJMGD-UHFFFAOYSA-N

安全信息

象形图GHS03GHS05GHS07GHS08GHS09
警示用语：Warning
危险声明H272 - H290 - H315 - H317 - H319 - H341 - H400
预防措施声明P210 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
危险分类Aquatic Acute 1 - Eye Irrit. 2 - Met. Corr. 1 - Muta. 2 - Ox. Sol. 3 - Skin Irrit. 2 - Skin Sens. 1B
储存分类代码5.1B - Oxidizing hazardous materials
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
8.01949Sigma-AldrichN-Bromosuccinimidefor synthesis268.36元/5 G;   404元/250 G;   818.15元/1 KG;   展开

产品说明

分析说明

Assay (iodometric): ≥ 99.0 %
Identity (IR): passes test

基本信息

经验(实验)分子式C4H4BrNO2
分子量177.98
MDL编号MFCD00005510
EC索引号204-877-2

产品性质

质量水平200
蒸汽压14.8 hPa ( 20 ℃)
形式powder
效能>2000 mg/kg LD50, oral (Rat)
reaction suitabilityreagent type: oxidant
mp174-179 ℃
溶解性 14.8 g/L (decomposition)
密度2.1 g/cm3 at 20 ℃
堆积密度750 kg/m3
储存温度2-8℃
InChI1S/C4H4BrNO2/c5-6-3(7)1-2-4(6)8/h1-2H2
InChI keyPCLIMKBDDGJMGD-UHFFFAOYSA-N

安全信息

象形图GHS03GHS05GHS07GHS08GHS09
警示用语：Warning
危险声明H272 - H290 - H315 - H317 - H319 - H341 - H400
预防措施声明P210 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
危险分类Aquatic Acute 1 - Eye Irrit. 2 - Met. Corr. 1 - Muta. 2 - Ox. Sol. 3 - Skin Irrit. 2 - Skin Sens. 1B
储存分类代码5.1B - Oxidizing hazardous materials
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
960668AmethystN-Bromosuccinimide99%, 用于合成58元/100G;   114元/500G;   208元/1KG;   展开

基本信息

分子式C4H4BrNO2
分子量177.99
熔点175-178
MDL编码MFCD00005510
EINECS 编号204-877-2
存储条件Store at 2-8℃

安全信息

图形或危害标志
提示语Danger
危险说明H302
H314
防范说明P280
P305+P351+P338
P310
UN号码3261
危险分类8
包装等级II
WGK3
TSCA是
BIOC-240NAccuStandardN-Bromosuccinimide340元/100mg;   展开
N-BromosuccinimideN-溴代琥珀酰亚胺128-08-5
FRACK-011NAccuStandardN-Bromosuccinimide340元/100mg;   展开
N-BromosuccinimideN-溴代琥珀酰亚胺128-08-5
BR1130FluorochemN-Bromosuccinimide>98%264元/100g;   484元/1kg;   2090元/5kg;   展开

基本信息

CAS Number128-08-5
MDL NumberMFCD00005510
Boiling Point338.9℃
Melting Point175-182℃
Density2.098

安全信息

图形或危害标志
危险性说明 H272: May intensify fire; oxidiser.
H290: May be corrosive to metals.
H315: Causes skin irritation.
H317: May cause an allergic skin reaction.
H319: Causes serious eye irritation.
H400: Very toxic to aquatic life.
防范说明 P210: Keep away from – No smoking.
P220: Keep/Store away from clothing/./combustible materials.
P221: Take any precaution to avoid mixing with combustibles/.
P234: Keep only in original container.
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P272: Contaminated work clothing should not be allowed out of the workplace.
P273: Avoid release to the environment.
P280: Wear .
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P321: Specific treatment (see .. on this label).
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P333 + P313: If skin irritation or rash occurs: Get medical advice/attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P362: Take off contaminated clothing and wash before reuse.
P363: Wash contaminated clothing before reuse.
P370 + P378: In case of fire: Use for extinction.
P390: Absorb spillage to prevent material damage.
P391: Collect spillage.
P406: Store in corrosive resistant/. container with a resistant inner liner.
P501: Dispose of contents/container to local regulations..
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