基本信息

技术规格

物性(参考值)

安全信息

图形或危害标志
信号词	危险
危险性说明	H361 : 怀疑对生育能力或胎儿造成伤害。 H340 : 可能造成遗传性缺陷。
防范说明	P501 : 将内装物/容器送到批准的废物处理厂处理。 P202 : 在阅读并明了所有安全措施前切勿搬动。 P201 : 使用前取得专用说明。 P280 : 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P308 + P313 : 如接触到或有疑虑：求医/就诊。 P405 : 存放处须加锁。

相关法规

运输信息

基本信息

产品描述

Hydroxyurea 是一种抗肿瘤药，通过抑制核苷二磷酸还原酶而抑制DNA合成。

靶点（IC50 & Targe）

ribonucleoside diphosphate reductase

体外研究

hydroxyurea can inhibit HIV-1 replication. In vitro experiments have shown that the 90% inhibitory concentration (IC90) of hydroxyurea for laboratory strains of HIV-1 in activated PBMC is 0.4 mM. Hydroxyurea was also found to be synergistic with the nucleoside reverse transcriptase inhibitor didanosine and to inhibit HIV-1 replication in activated PBMC; this inhibition may be due to a reduction in deoxynucleoside triphosphate pool sizes. Hydroxyurea has been shown to sensitize didanosine-resistant mutants[1][2].hydroxyurea has demonstrated activity in the treatment of sickle cell anemia by increasing the production of fetal hemoglobin, which reduces hemolysis in patients with this disease. Hydroxyurea exerts its cytostatic effect through inhibition of ribonucleotide reductase—the rate-limiting enzyme responsible for the conversion of ribonucleotides to deoxyribonucleotides, which are essential for DNA synthesis. As a result, cellular division is arrested in the S phase[1].

细胞实验

Cell lines: Erythroid cells

Concentrations: 30 μM

Incubation Time: 96 h

Method: Erythroid cells obtained from peripheral blood of the same patients(Thirteen β-Thal/HbE patients are treated with hydroxyurea orally for 2 years at a starting dose of 5 mg/kg/day for 5 days/week with escalation to a maximum of 10 mg/kg/day) 1 year after they had stopped hydroxyurea treatment are treated with hydroxyurea in vitro.Treatment of cells performs in primary culture with 30 μM hydroxyurea for 96 hours.

(Only for Reference)

动物实验

Animal Models: Female athymic (nu/nu) nude mice(used for xenograft model)

Formulation: saline

Dosages: 1500 mg/kg

Administration: i.p.

(Only for Reference)

参考文献

[1] Lori F, et al. Clin Infect Dis. 2000, 30 Suppl 2:S193-7.

[2] Zala C, et al. Clin Infect Dis. 2000, Suppl 2:S143-50.

[3] Watanapokasin Y, et al. Exp Hematol. 2005, 33(12):1486-92.

[4] Boucher PD, et al. Gene Ther. 2002, 9(15):1023-30.

安全信息

图形或危害标志
提示语	Warning
危险说明	H340 H361
防范说明	P201 P281 P308+P313
UN号码	2811
危险分类	6.1
包装等级	III
WGK	3
RTECS	YT4900000
TSCA	否

应用
Hydroxyurea is used as an inhibitor of DNA synthesis and an anti-cancer drug. It is used as a precursor to prepare 1-hydroxy-5,6-dimethyl-1H-pyrimidine-2,4-dione via reaction with 2-methyl-3-oxo-butyric acid ethyl ester. It is used in the treatment of melanoma, resistant chronic myelocytic leukemia and recurrent metastatic or inoperable ovarian. It is also involved in reducing the rate of painful attacks in sickle-cell disease and has anti-retroviral properties in diseases such as AIDS.

备注
Moisture sensitive. Store in cool place. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents.

基本信息

MDL
MFCD00007943

EINECS
204-821-7

分子式
CH₄N₂O₂

分子量
76.06

熔点
ca 140° dec.

灵敏度
Ambient temperatures.

形态
Crystalline powder

溶解性
Soluble in water, hot alcohol and dimethyl sulfoxide. Insoluble in ethanol and benzene.

Beilstein
1741548

Merck
14,4848

GHS危害和防范说明

GHS符号

Hazard Statements
H340-H360
May cause genetic defects.May damage fertility or the unborn child.

Precautionary Statements
P201-P280-P202-P308+P313-P405-P501a
Obtain special instructions before use.Wear protective gloves/protective clothing/eye protection/face protection.Do not handle until all safety precautions have been read and understood.IF exposed or concerned: Get medical advice/attention.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
46-61
May cause heritable genetic damage.May cause harm to the unborn child.

安全等级
53-20-36-45
Avoid exposure - obtain special instructions before use.When using do not eat or drink.Wear suitable protective clothing.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

RTECS
YT4900000

TSCA
否

基本信息

Ref#
15168

MDL
7943

分子式
C H4 N2 O2

分子量
76.04

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

抗肿瘤剂。通过形成自由基硝基氧灭活核糖核苷还原酶，自由基硝基氧可结合到酶活性位点的酪氨酰自由基。这可阻断脱氧核苷酸的合成，从而抑制 DNA 合成，并且诱导细胞周期同步化或 S-期细胞死亡。

包装

Unit quantity: 360 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H340 - H361
预防措施声明	P201 - P308 + P313
危险分类	Muta. 1B - Repr. 2
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

产品说明

应用

羟基脲用于：

• MCF-7人乳腺肿瘤细胞、分裂酵母、苗木主根中的细胞周期同步化
• 在细胞活性和细胞周期实验中，治疗Leishmania mexicana寄生虫
• 在Caki对照和CD9下调细胞的细胞粘附和迁移检测实验中，用作抑制剂

包装

1, 5, 10, 25, 100 g in poly bottle

生化/生理作用

抗肿瘤剂。通过形成自由基硝基氧灭活核糖核苷还原酶，自由基硝基氧可结合到酶活性位点的酪氨酰自由基。这可阻断脱氧核苷酸的合成，从而抑制 DNA 合成，并且诱导细胞周期同步化或 S-期细胞死亡。

特点和优势

该化合物是细胞凋亡研究的特色产品。点击此处 ，查看更多细胞凋亡精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问sigma.com/discover-bsm。

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H340 - H361
预防措施声明	P201 - P308 + P313
危险分类	Muta. 1B - Repr. 2
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

抗肿瘤剂。通过形成自由基硝基氧灭活核糖核苷还原酶，自由基硝基氧可结合到酶活性位点的酪氨酰自由基。这可阻断脱氧核苷酸的合成，从而抑制 DNA 合成，并且诱导细胞周期同步化或 S-期细胞死亡。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H340 - H361
预防措施声明	P201 - P280 - P308 + P313
危险分类	Muta. 1B - Repr. 2
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

产品说明

一般描述

Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes. Reported to enhance the radiation effects in pancreatic adenocarcinoma cells. Releases NO in the presence of oxidizing agents.
Antineoplastic agent. Blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes.

包装

5 g in Plastic ampoule

生化/生理作用

Primary Target
Inhibiting ribonucleotide reductase
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Carcinogenic / Teratogenic (D)

重悬

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 months at 4°C.

其他说明

Leyden, D., et al. 2000. Anticancer Res.20, 133.
Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
Anand, S., et al. 1995. Cancer Lett.88, 101.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H340 - H361
预防措施声明	P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类	Muta. 1B - Repr. 2
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

产品说明

包装

100, 250 g in poly bottle

生化/生理作用

抗肿瘤剂。通过形成自由基硝基氧灭活核糖核苷还原酶，自由基硝基氧可结合到酶活性位点的酪氨酰自由基。这可阻断脱氧核苷酸的合成，从而抑制 DNA 合成，并且诱导细胞周期同步化或 S-期细胞死亡。

法律信息

Vetec is a trademark of sigma-aldrich International GmbH

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H340 - H361
预防措施声明	P201 - P281 - P308 + P313
危险分类	Muta. 1B - Repr. 2
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

抗肿瘤剂。通过形成自由基硝基氧灭活核糖核苷还原酶，自由基硝基氧可结合到酶活性位点的酪氨酰自由基。这可阻断脱氧核苷酸的合成，从而抑制 DNA 合成，并且诱导细胞周期同步化或 S-期细胞死亡。

包装

Unit quantity: 200 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H340 - H361
预防措施声明	P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类	Muta. 1B - Repr. 2
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

基本信息

安全信息

图形或危害标志
危险性说明	H302: Harmful if swallowed. H312: Harmful in contact with skin. H332: Harmful if inhaled. H340: May cause genetic defects .. H361: Suspected of damaging fertility or the unborn child ..
防范说明	P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P261: Avoid breathing . P264: Wash hands thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P281: Use personal protective equipment as required. P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P308 + P313: IF exposed or concerned: Get medical advice/ attention. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific measures (see . on this label). P330: Rinse mouth. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to local regulations.