CAS 1269267-87-9; ghp-88309

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CAS:

1269267-87-9

英文名称:

ghp-88309

ghp88309

2-fluoro-6-(5-isoquinolinyl)benzamide; 2-fluoro-6-(5-isoquinolyl)benzamide

ghp 88309

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货号

品牌

产品名称

规格

包装、参考价格

详情

SML2997

Sigma-Aldrich

GHP-88309

≥98% (HPLC)

1452.63元/5 MG; 5846.97元/25 MG;

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产品说明

生化/生理作用

GHP-88309 is an orally available non-nucleoside paramyxovirus polymerase inhibitor with broad-spectrum anti-paramyxoviral activity (EC50 in μM= 0.4/HPIV3-JS, 0.8/HPIV3-5F6, 2/SeV-F1R-eGF, 0.6/MeV/Alaska.USA 16.00, 0.4/CDV-5804p) and little cytoxicity (CC50 >20μM). GHP-88309 potently inhibits the replication of HPIV1 isolate 5F6 and HPIV3 isolates 10L3 & 9R4 in 3D-ALI-HBTEC human airway organoids (EC50 = 280,90, 105 nM, respectively) in 3D-ALI-HBTECs. HPIV3 and provides complete protection against lethal Sendai virus infection in mice (150 mg/kg bid. po. starting at time of infection or 48 hrs after), a murine surrogate model of human HPIV3 disease.

基本信息

经验(实验)分子式	C₁₆H₁₁FN₂O
分子量	266.27

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	FC1=C(C(N)=O)C(C2=C(C=CN=C3)C3=CC=C2)=CC=C1

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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