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CAS: 125628-97-9
分子式: C13H8FNO5
分子量: 277.2
英文名称: 
(3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)-methanon
(3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)methanone
or 1139
ro 41-0960
推荐供应商
货号品牌产品名称规格包装、参考价格
D727397MACKLIN(3,4-二羟基-5-硝基苯基)(2-氟苯基)甲酮99%884元/25mg;   1503元/50mg;   2554元/100mg;   咨询
储存:-20°C, 干燥, 避光
R108Sigma-AldrichRo 41-0960solid1642.3元/25 MG;   5216.03元/100 MG;   咨询

产品说明

应用

Ro 41-0960 has been used as an inhibitor of catechol-O-methyl-transferase in synaptosome membrane preparations and 3T3-L1 adipocytes. It has also been used as a catechol-O-methyl-transferase inhibitor to treat corpus striatum samples to test its effect on dopamine metabolism.

包装

25, 100 mg in poly bottle

生化/生理作用

Ro 41-0960 is a specific and synthetic inhibitor of the enzyme catechol-O-methyl-transferase (COMT). It binds to the catalytic site and triggers the inhibition of the methylation property of COMT. Ro 41-0960 is effective on uterine leiomyoma lesions and uterine fibroids.

特点和优势

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

注意

Store tightly sealed at 4 ℃, protected from exposure to light.

基本信息

经验(实验)分子式C13H8FNO5
分子量277.20
MDL编号MFCD00078597
PubChem化学物质编号24278193
NACRESNA.77

产品性质

质量水平100
形式solid
储存条件protect from light
颜色 yellow
溶解性H2O: slightly soluble <0.7 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.0 mg/mL
ethanol: soluble
储存温度2-8℃
SMILES stringOc1cc(cc(c1O)[N+]([O-])=O)C(=O)c2ccccc2F
InChI1S/C13H8FNO5/c14-9-4-2-1-3-8(9)12(17)7-5-10(15(19)20)13(18)11(16)6-7/h1-6,16,18H
InChI keyRQPAUNZYTYHKHA-UHFFFAOYSA-N
Gene Informationhuman ... COMT(1312)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)
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