CAS 1243583-85-8; mg-149

CAS:

1243583-85-8

分子式:

C₂₂H₂₈O₃

分子量:

340.46

英文名称:

mg-149

用途:

MG149 是强效的histone acetyltransferase抑制剂，其作用于Tip60和MOF的IC50分别为74 μM 和 47 μM。MG149以乙酰辅酶A结合位点为靶点，抑制从小鼠不同大脑区域组织样本中提取的细胞核的乙酰转移酶活性。[1] MG149也会抑制p53 和NF-κB信号通路。[2]

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

M794239

MACKLIN

MG149

10mM in DMSO

648元/1ml;

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储存：-20°C

M872736

MACKLIN

MG149

99%

719元/5mg; 2499元/25mg; 5880元/100mg;

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储存：-20℃
状态：白色到灰白色固体

SML3011

Sigma-Aldrich

MG149

≥98% (HPLC)

1584.58元/5 MG; 5100.38元/25 MG;

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产品说明

生化/生理作用

MG149 is cell-permeable anacardic acid analog that displays higher selectivity towards MYST type HATs (IC50 = 47 and 74 μM against MOF and Tip60; Ki for KAT8 = 39 μM) over p300 and PCAF (IC50 > 200 and >> 200 uM). Tip60 inhibition is shown to be Ac-CoA competitive and histone substrate non-competitive and KAT8 inhibition is Ac-CoA uncompetitive. MG149 treatment lowers histone acetylation levels and cellular proliferation rate, induces apoptosis and dose-dependently alters pro-inflammatory cytokines/chemokines expression. Enhances JQ1-induced HIV latency reversal, suppresses NOX transcription and ameliorates ROS levels.

基本信息

经验(实验)分子式	C₂₂H₂₈O₃
分子量	340.46
MDL编号	MFCD22123243

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	OC1=C(C(CCC2=CC=C(C=C2)CCCCCCC)=CC=C1)C(O)=O

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable