CAS 124182-57-6; cgs-21680 hydrochloride

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货号

品牌

产品名称

规格

包装、参考价格

C920926

MACKLIN

2-p-(2-羧乙基)苯乙氨基-5′-N-乙基甲酰胺基腺苷盐酸盐水合物

98% (HPLC)

990元/5mg; 3780元/25mg;

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储存：−20°C
状态：白色固体

119137

Sigma-Aldrich

Adenosine A2A Receptor Agonist I, CGS 21680, Hydrochloride-CAS 124182-57-6-Calbiochem

2345.3元/5 MG;

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产品说明

一般描述

A xanthin derivative that acts as a potent agonist of adenosine A_2A receptors (K_i = 27 nM). Exhibits reduced affinity for A_2B receptors (K_i = 67 nM), but offers greater selectivity over A_1R (K_i = 290 nM) and A_3R (88.8 µM). Exerts an anti-inflammatory effect during chronic inflammation and ameliorates the tissue damage associated with collagen-induced arthritis. Also shown to reduce CCR7 Protein Expression in THP1 macrophages. Shown to delay the progressive deterioration of motor performance and prevent a reduction in brain weight in murine model of Huntington′s disease. Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
A xanthin derivative that acts as a potent agonist of adenosine A_2A receptors (K_i = 27 nM). Exhibits reduced affinity for A_2B receptors (K_i = 67 nM), but offers greater selectivity over A_1R (K_i = 290 nM) and A_3R (88.8 µM). Exerts an anti-inflammatory effect during chronic inflammation and ameliorates the tissue damage associated with collagen-induced arthritis. Also shown to reduce CCR7 Protein Expression in THP1 macrophages. Shown to delay the progressive deterioration of motor performance and prevent a reduction in brain weight in murine model of Huntington′s disease.

包装

5 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

外形

Supplied as a hydrochloride salt.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Willians, A. J., et al. 2012. Inflammation.35, 614.
Mazzon, E. et al. 2011. J Rheumatol.38, 2119,
Martire, A., et al. 2007. Neurosci Lett.417, 78.
Chou, S. Y., et al, 2005. Journ Neurochem.93, 310.
Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol.362 382.
Phillis, J. W., et al. 1990.Brain Res.509, 328.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₃H₂₉N₇O₆ · xHCl
分子量	499.52 (free base basis)

产品性质

质量水平	100
测定	≥96% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	white
溶解性	DMSO: 100 mM
运输	ambient
储存温度	−20℃
InChI	1S/C23H29N7O6/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29)/t16-,17+,18-,22?/m0/s1
InChI key	PAOANWZGLPPROA-OFRRTHGGSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

C141

Sigma-Aldrich

CGS-21680 hydrochloride hydrate

solid

2800.96元/5 MG; 4140.44元/10 MG; 10062元/25 MG;

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产品说明

包装

5, 10, 25, 100 mg in glass bottle

生化/生理作用

腺苷受体激动剂，对 A ₂ 和 A ₁ 受体具有选择性。

注意

吸湿

基本信息

经验(实验)分子式	C₂₃H₂₉N₇O₆ · HCl · xH₂O
分子量	535.98 (anhydrous basis)
MDL编号	MFCD11045878
PubChem化学物质编号	24277698
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
储存条件	desiccated
颜色	white
溶解性	DMSO: >10 mg/mL 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 20 mg/mL
储存温度	−20℃
SMILES string	O.Cl.CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)nc(NCCc4ccc(CCC(O)=O)cc4)nc23
InChI	1S/C23H29N7O6.ClH.H2O/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32;;/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29);1H;1H2/t16-,17+,18-,22+;;/m0../s1
InChI key	VIRPCGAECNOLOO-VBQNEDDFSA-N
Gene Information	human ... ADORA2A(135), ADORA2B(136)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)