CAS 1233332-14-3; n-[[3′-[[(1R)-1-(4-chloro-3-methylphenyl)ethyl]amino]-3,5-dimethyl[1,1′-biphenyl]-4-yl]carbonyl]-l-alanine; nibr-0213

位置：首页 > 资料中心 > 化工字典 > 1233332-14-3

CAS:

1233332-14-3

分子式:

C₂₇H₂₉ClN₂O₃

分子量:

464.98

中文名称:

n-[[3′-[[(1R)-1-(4-chloro-3-methylphenyl)ethyl]amino]-3,5-dimethyl[1,1′-biphenyl]-4-yl]carbonyl]-l-alanine

(S)-2-({3′-[(R)-1-(4-chloro-3-methyl-phenyl)-ethylamino]-3,5-dimethyl-biphenyl-4-carbonyl}-amino)-propionic acid

英文名称:

nibr-0213

nibr0213

nibr 0213

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

R727699

MACKLIN

(3'-(((R)-1-(4-氯-3-甲基苯基)乙基)氨基)-3,5-二甲基-[1,1'-联苯]-4-羰基)-L-丙氨酸

99%

407元/1mg; 1420元/5mg; 2130元/10mg;

展开

储存：-20°C, 干燥

SML2099

Sigma-Aldrich

NIBR-0213

≥98% (HPLC)

1649.92元/5 MG; 5909.96元/25 MG;

展开

产品说明

应用

NIBR-0213 may be used as a selective sphingosine-1-phosphate receptor 1 (S1P1) antagonist to assess S1P-mediated nuclear factor kappa B (NF-κB)-p65 nuclear translocation in human induced astrocytes.

生化/生理作用

NIBR-0213 is an orally active, potent and S1P1-selective sphingosine 1-phosphate (S1P) receptor antagonist that blocks S1P1-selective ligand AUY954-induced Ca²⁺ mobilization (IC50 = 2.5 nM using human S1P1-transfected HeLa cells; IC50 >10 μM with human S1P2, S1P3, or S1P4 transfectants) and S1P-induced GTPγS recruitment (IC50 = 2.0/2.3/8.5 nM using membrane from human/murine/rat S1P1-transfected CHO cells; IC50 >10 μM with membrane from human S1P5 transfectant). NIBR-0213 induces long-lasting peripheral blood lymphocyte reduction in rats (EDmax = 1 mg/kg, ED50 = 0.2 mg/kg; p.o.) and exhibits therapeutic efficacy (30 mg/kg p.o; BID) in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS), with no adverse effects to the animals.

基本信息

经验(实验)分子式	C₂₇H₂₉ClN₂O₃
分子量	464.98
MDL编号	MFCD25977008

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	−20℃
SMILES string	C[C@@H](C(O)=O)NC(C1=C(C)C=C(C2=CC=CC(N[C@@H](C3=CC=C(Cl)C(C)=C3)C)=C2)C=C1C)=O

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

CAS号首数字顺序排列： 1 2 3 4 5 6 7 8 9