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CAS: 123-99-9
分子式: C9H16O4
分子量: 188.22
沸点: 237℃(15.
熔点: 98℃
中文名称: 
杜鹃花酸
1,7-壬二酸
庚烷-1,7-二羟酸
王二酸
壬二酸
英文名称: 
1,9-nonanedioic acid
Nonanedioic acid
1,7-heptanedicarboxylic acid
anchoic acid
azelaic acid
azelaic acid, technical grade
emerox 1110
emerox 1144
heptanedicarboxylic acid
lepargylic acid
Nonanedionic acid
azelaic
azelaicacid
展开更多英文名
性质描述: 该品为白色至微黄色单斜棱晶、针状结晶体或粉末。熔点为106.5℃,沸点>360(部分分解),226℃(1.33kPa),287℃(13.3kPa),相对密度1.225(25/4℃),折光率1.4303(111℃)。易溶于热水、醇及热苯,微溶于水、醚和苯。
生产方法: 由油酸经硝酸氧化或臭氧氧化而得。也可以用工业蓖麻作原料裂解而得。1,5-二溴戊烷与乙腈缩合,或者以戊二酸单甲酯单酰氰为原料经酮式壬二酸二甲酯都可以制取壬二酸。
用途: 大部分壬二酸用于生产壬二酸二辛酯(DOZ)增塑剂,其他的用途是作为香料、润滑油、油剂、聚酰胺树脂的原料。DOZ用作电缆、薄膜、人造革等用的耐寒性增塑性,挥发性小,耐老化性也好。DOZ也可用作合成橡胶的软化剂。日本生产DOZ所用的壬二酸约占壬二酸总消费量的70%。壬二酸通氨脱水,可制取壬二腈。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
A800647MACKLIN壬二酸99%30元/25g;   60元/100g;   165元/500g;   697元/2.5kg;   展开
储存:室温,密封
状态:白色到淡黄色粉末或晶体
A889454MACKLIN壬二酸95%29元/25g;   33元/100g;   143元/500g;   612元/2.5kg;   展开
储存:室温,密封
状态:白色到淡黄色粉末或晶体
A0561TCIAzelaic Acid>80.0%(GC)120元/25G;   265元/500G;   展开

基本信息

纯度/分析方法>80.0%(GC)
分子式/分子量C9H16O4 = 188.22
外观与形状(20℃)固体
Reaxys-RN1101094
PubChem物质ID87562155
SDBS (AIST Spectral DB)1530
Merck Index (14)905
MDL编号MFCD00004432

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(GC)min. 80.0 %
Melting point102.0 to 105.0 ℃

物性(参考值)

熔点103 ℃
沸点360 ℃
水溶性实际上不溶
在水中的溶解度2.4 g/l   20 ℃
溶解性(可溶于)乙醇,甲醇,丙酮
溶解度(极微溶)苯,乙醚

安全信息

信号词警告
危险性说明H316 : 造成轻微皮肤刺激。
H320 : 造成眼刺激。
防范说明P264 : 作业后彻底清洗皮肤。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P332 + P313 : 如发生皮肤刺激:求医/就诊。

相关法规

RTECS#CM1980000
A1318TCIAzelaic Acid>98.0%(GC)(T)220元/25G;   990元/250G;   展开

基本信息

纯度/分析方法>98.0%(GC)(T)
分子式/分子量C9H16O4 = 188.22
外观与形状(20℃)固体
Reaxys-RN1101094
PubChem物质ID87562778
SDBS (AIST Spectral DB)1530
Merck Index (14)905
MDL编号MFCD00004432

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(GC)min. 98.0 %
Purity(Neutralization titration)min. 98.0 %
Melting point106.0 to 109.0 ℃
Solubility in hot Wateralmost transparency

物性(参考值)

熔点108 ℃
沸点306 ℃
水溶性实际上不溶
在水中的溶解度2.4 g/l   20 ℃
溶解性(可溶于)甲醇,乙醇,丙酮
溶解度(极微溶)苯,乙醚

安全信息

信号词警告
危险性说明H316 : 造成轻微皮肤刺激。
H320 : 造成眼刺激。
防范说明P264 : 作业后彻底清洗皮肤。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P332 + P313 : 如发生皮肤刺激:求医/就诊。

相关法规

RTECS#CM1980000
A17271Alfa AesarAzelaic Acidtech. 80%550元/500g;   2075元/2500g;   展开

应用
It is applied in organic synthesis, lacquers, polyester adhesives, and urethane elastomers. Azelaic acid directly inhibits kallikrein 5 (KLK5), down regulating expression of KLK5, toll-like receptor 2 (TLR 2), and cathelicidin, and suppresses activity of serine proteases in vitro, in vivo, and in clinical settings. In PUFA-treated fibroblasts, azelaic acid decreases generation of ROS and up regulates expression of antioxidative enzymes, inhibiting cell damage; agonist activity at PPAR? is thought to drive these effects. Azelaic acid also inhibits proliferation of melanocytes. This compound displays antiacne and anticancer potential as well, inhibiting the proliferation of cutaneous melanoma due to suppression of mitochondrial oxidoreductive activity and DNA synthesis. It is a component of a number of hair and skin conditioners. Azelaic acid is used to treat mild to moderate acne, both comedonal acne and inflammatory acne. It is used in lubrication and plasticizers.

备注
Store away from strong oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

基本信息

MDL
MFCD00004432

EINECS
204-669-1

分子式
HOOC(CH2)7COOH

分子量
188.22

熔点
ca 102°

沸点
286°/100mm

闪点
215°(419°F)

密度
1.225

灵敏度
Ambient temperatures.

形态
Crystalline

溶解性
Soluble in water at 20°C 2.4 g/L. Soluble in ethanol (5%), DMSO, methanol (70 mg/ml), and alcohol.

Beilstein
1101094

Merck
14,905

安全信息

RTECS
CM1980000

TSCA

042587Alfa AesarAzelaic Acid96%284元/25g;   754元/100g;   3046元/500g;   展开

应用
Azelaic acid acts as an anti-inflammatory compound. It is also exhibits anti acne activity. It up regulates expression of ant oxidative enzymes. Azelaic acid also inhibits proliferation of melanocytes.

备注
Store at 4?°C-store in a cool, dry condition and well-ventilated containers. Incompatible with bases and strong oxidizing agents.

基本信息

MDL
MFCD00004432

EINECS
204-669-1

分子式
HOOC(CH2)7COOH

分子量
188.22

熔点
ca 102°

沸点
286°/100mm

闪点
215°(419°F)

密度
1.225

灵敏度
Ambient temperatures.

形态
Crystalline

溶解性
Soluble in water (2.4 mg/ml at 20°C), ethanol (5%), DMSO, methanol (70 mg/ml), and alcohol.

Beilstein
1101094

Merck
14,905

安全信息

RTECS
CM1980000

TSCA

036308Alfa AesarAzelaic Acid98%360元/25g;   929元/100g;   3508元/*5x100g;   展开

应用
Useful in lubrication and plasticizers. Azelaic acid is used to treat acne.

备注
It is stable under room temperatures and atmospheric pressures.

基本信息

MDL
MFCD00004432

EINECS
204-669-1

分子式
HOOC(CH2)7COOH

分子量
188.22

熔点
ca 102°

沸点
286°/100mm

闪点
215°(419°F)

密度
1.225

灵敏度
Ambient temperatures.

形态
Crystalline

溶解性
Soluble in water

Beilstein
1101094

Merck
14,905

安全信息

RTECS
CM1980000

TSCA

C40152Alfa AesarAzelaic Acid98%703元/25g;   1095元/100g;   4280元/500g;   展开

基本信息

Ref#
40152

MDL
4432

分子式
C9 H16 O4

分子量
188.22

闪点
215

形态
Crystalline

A96150Sigma-AldrichAzelaic Acidtechnical grade, 80%690.66元/2 KG;   展开

产品说明

一般描述

Azelaic acid is used as a therapeutic agent in dermatology.

应用

Azelaic acid, a bolaamphiphile, is generally used as a spacer/linker in synthetic chemistry. Some of the applications include:

  • Synthesis of pH-responsive metallo-hydrogels as potential dye-adsorbing agents, and vitamin B12 carriers.
  • Synthesis of fluorescent uranyl (UO22+) coordination polymers.
  • Synthesis of various metal-organic frameworks (MOFs) and supramolecular macrocyclic adducts.
  • Conversion of hydrophobic up-converting rare-earth nanophosphors (UCNPs) into water-soluble, carboxylic acid-functionalized analogs to facilitate conjugation with biomolecules such as streptavidin.

包装

2 kg in poly bottle

基本信息

线性分子式HO2C(CH2)7CO2H
分子量188.22
Beilstein1101094
EC 号204-669-1
MDL编号MFCD00004432
PubChem化学物质编号24891477
NACRESNA.22

产品性质

等级technical grade
质量水平100
蒸汽密度6.5 (vs air)
蒸汽压<1 mmHg ( 20 ℃)
测定80%
bp286 ℃/100 mmHg (lit.)
mp109-111 ℃ (lit.)
SMILES stringOC(=O)CCCCCCCC(O)=O
InChI1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)
InChI keyBDJRBEYXGGNYIS-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H315 - H319
预防措施声明P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
危险分类Eye Irrit. 2 - Skin Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)410.0 °F - closed cup
闪点(C)210 ℃ - closed cup
个人防护装备Eyeshields, Gloves, type N95 (US)
8.20116Sigma-AldrichAzelaic acid,technical grade for synthesis293.75元/100 G;   612.71元/1 KG;   展开

产品说明

分析说明

Assay (GC, area%): ≥ 90.0 % (a/a)
Identity (IR): passes test

基本信息

线性分子式HOOC(CH2)7COOH
分子量188.22
MDL编号MFCD00004432
EC索引号204-669-1

产品性质

质量水平200
蒸汽压<1 hPa ( 20 ℃)
测定≥90.0% (GC)
形式crystals
效能>4000 mg/kg LD50, oral (Rat)
>10 g/kg LD50, skin (Rat)
pH值(酸碱度)3.5 (1 g/L in H2O)
bp237 ℃/20 hPa
mp107 ℃
转变温度flash point 215 ℃
密度1.029 g/cm3 at 20 ℃
储存温度2-30℃
InChI1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)
InChI keyBDJRBEYXGGNYIS-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H315 - H319
预防措施声明P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
危险分类Eye Irrit. 2 - Skin Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)419.0 °F
闪点(C)215 ℃
246379Sigma-AldrichAzelaic Acid98%480.77元/25 g;   1175.9元/100 G;   展开

基本信息

线性分子式HO2C(CH2)7CO2H
分子量188.22
Beilstein1101094
EC 号204-669-1
MDL编号MFCD00004432
PubChem化学物质编号24278221
NACRESNA.23

产品性质

质量水平200
蒸汽密度6.5 (vs air)
蒸汽压<1 mmHg ( 20 ℃)
测定98%
形式powder
bp286 ℃/100 mmHg (lit.)
mp109-111 ℃ (lit.)
SMILES stringOC(=O)CCCCCCCC(O)=O
InChI1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)
InChI keyBDJRBEYXGGNYIS-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H315 - H319
预防措施声明P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
危险分类Eye Irrit. 2 - Skin Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)410.0 °F - closed cup
闪点(C)210 ℃ - closed cup
个人防护装备Eyeshields, Gloves, type N95 (US)
11480Sigma-AldrichAzelaic Acidtechnical, ~85% (GC)583.45元/250 G;   1206.52元/1 KG;   展开

产品说明

一般描述

Azelaic acid (Nonanedioic acid) is a naturally occurring saturated, nonphenolic compound isolated from cultures Pityrosporum ovale. It is a therapeutic agent with well-known antibacterial properties.

生化/生理作用

Azelaic acid is a potent inhibitor of 5α-reductase activity. It is a reversible competitive inhibitor of thioredoxin reductase in human melanoma cells.

基本信息

线性分子式HO2C(CH2)7CO2H
分子量188.22
Beilstein1101094
EC 号204-669-1
MDL编号MFCD00004432
PubChem化学物质编号329749451
NACRESNA.22

产品性质

质量水平200
蒸汽密度6.5 (vs air)
蒸汽压<1 mmHg ( 20 ℃)
等级technical
测定~85% (GC)
bp286 ℃/100 mmHg (lit.)
mp109-111 ℃ (lit.)
SMILES stringOC(=O)CCCCCCCC(O)=O
InChI1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)
InChI keyBDJRBEYXGGNYIS-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H319
预防措施声明P305 + P351 + P338
危险分类Eye Irrit. 2
储存分类代码13 - Non Combustible Solids
WGKWGK 1
闪点(F)410.0 °F - closed cup
闪点(C)210 ℃ - closed cup
个人防护装备Eyeshields, Gloves, type N95 (US)
V900595Sigma-AldrichAzelaic AcidVetec, reagent grade228.58元/100 G;   574.63元/500 G;   展开

产品说明

包装

100, 500 g in poly bottle

法律信息

Vetec is a trademark of sigma-aldrich International GmbH

基本信息

线性分子式HO2C(CH2)7CO2H
分子量188.22
Beilstein1101094
EC 号204-669-1
MDL编号MFCD00004432
PubChem化学物质编号329829955

产品性质

等级reagent grade
蒸汽密度6.5 (vs air)
蒸汽压<1 mmHg ( 20 ℃)
产品线Vetec
bp286 ℃/100 mmHg (lit.)
mp109-111 ℃ (lit.)
SMILES stringOC(=O)CCCCCCCC(O)=O
InChI1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)
InChI keyBDJRBEYXGGNYIS-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H319
预防措施声明P305 + P351 + P338
危险分类Eye Irrit. 2
储存分类代码13 - Non Combustible Solids
WGKWGK 1
闪点(F)410.0 °F - closed cup
闪点(C)210 ℃ - closed cup
95054SupelcoAzelaic Acidanalytical standard1151.38元/100 MG;   展开

产品说明

一般描述

壬二酸(庚烷-1,7-二羧酸)是一种二羧酸饱和酸,它是某些外用抗痤疮制剂的活性成分。据报道它存在于化妆品和药物。研究发现壬二酸抑制丙酸杆菌的生长并减少角质化。

应用

壬二酸可用作定量测定以下物质中分析物的分析参考标准品:

  • 烟草,通过气相色谱-质谱联用法(GC-MS)。
  • 外用制剂,通过反相液相色谱(LC)和紫外可见光检测。


有关合适的仪器技术的更多信息,请参阅产品的分析证书。想要获得更多支持,请联系技术服务部。

基本信息

线性分子式HO2C(CH2)7CO2H
分子量188.22
Beilstein1101094
EC 号204-669-1
MDL编号MFCD00004432
PubChem化学物质编号329770414
NACRESNA.24

产品性质

质量水平100
等级analytical standard
蒸汽密度6.5 (vs air)
蒸汽压<1 mmHg ( 20 ℃)
测定≥98.5% (GC)
保质期limited shelf life, expiry date on the label
technique(s)HPLC: suitable
gas chromatography (GC): suitable
杂质≤0.5% water
bp286 ℃/100 mmHg (lit.)
mp106-112 ℃
109-111 ℃ (lit.)
application(s)cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
格式neat
SMILES stringOC(=O)CCCCCCCC(O)=O
InChI1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)
InChI keyBDJRBEYXGGNYIS-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H315 - H319
预防措施声明P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
危险分类Eye Irrit. 2 - Skin Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)410.0 °F - closed cup
闪点(C)210 ℃ - closed cup
506266AmethystAzelaic Acid99%, 试剂级58元/25G;   134元/100G;   415元/500G;   1528元/2.5KG;   展开

基本信息

分子式C9H16O4
分子量188.22
熔点109-111
沸点286
闪点210
MDL编码MFCD00004432
Beilstein1101094
Merck14,905
EINECS 编号204-669-1

安全信息

防范说明P262
WGK1
RTECSCM1980000
M01351FluorochemAzelaic Acid= 99% (Assay)440元/25g;   1122元/100g;   1958元/250g;   5874元/1kg;   展开

基本信息

CAS Number123-99-9
MDL NumberMFCD00004432

安全信息

图形或危害标志
危险性说明 H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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