| CAS: | 1223397-11-2 | |||
| 分子式: | C20H13FO6 | |||
| 分子量: | 368.31 | |||
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| 用途: | WZB117是GLUT1的抑制剂，它可以抑制肺癌细胞A549和乳腺癌MCF7细胞的细胞增殖，IC50约为10 μM。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||||||||||||||
| W793896 | MACKLIN | WZB117 | 10mM in DMSO | 720元/1ml; | 展开 | ||||||||||||||||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||||||||||||||||
| W872568 | MACKLIN | WZB117 | 99% | 180元/5mg; 320元/25mg; 565元/100mg; 960元/250mg; 2588元/1g; | 展开 | ||||||||||||||||||||||||||||||||||||||||
储存：-20℃ 状态：白色到灰白色粉末 | |||||||||||||||||||||||||||||||||||||||||||||
| SML0621 | Sigma-Aldrich | WZB-117 | ≥98% (HPLC) | 1497.87元/5 MG; 4684.02元/25 MG; | 展开 | ||||||||||||||||||||||||||||||||||||||||
产品说明 应用 WZB-117 已被用于研究其在肿瘤干细胞中的肿瘤起始能力。也用于研究葡萄糖拮抗剂对 2-NBDG(2-(N-(7-硝基苯并-2-氧杂-1,3-二唑-4-基)氨基)-2-脱氧葡萄糖)摄取的影响。 包装 5, 25 mg in glass bottle 生化/生理作用 WBZ 117 是 H1299 肺癌和其他癌细胞中基础葡萄糖转运的抑制剂。 基本信息
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| 400036 | Sigma-Aldrich | Glucose Transporter Inhibitor IV, WZB117-CAS 1223397-11-2-Calbiochem | The Glucose Transporter Inhibitor IV, WZB117 controls the biological activity of Glucose Transporter. | 3124.36元/25 MG; | 展开 | ||||||||||||||||||||||||||||||||||||||||
产品说明 一般描述 A bis-hydroxybenzoate compound that acts as a fast-acting, irreversible blocker of glucose transport by GLUT1 in red blood cells. Shown to rapidly inhibit glucose transport in cancer cells (IC50 ~ 500 nM in A549 cells) and block proliferation. Its inhibitory effects are more pronounced in hypoxic cancer cells. It binds directly to GLUT1 involving three hydrogen bonds, one each with Asn34, Arg126, and Trp412. Also shown to reduce the levels of GLUT1 protein, intracellular ATP levels, and glycolytic enzymes and increase the level of AMPK in tumor cells. Preferentially induces cell cycle arrest and causes senescence and necrosis in red blood cells and tumor cells (IC50 = 10 µM) over non cancerous cells and synergizes the anti-tumor effects of cisplatin (>Cat. No. 232120) and paclitaxel (>Cat. No. 580555). Also, effectively suppresses tumor growth in human A549 lung cancer grafted nude mice model (10 mg/kg, i.p., daily). 包装 25 mg in Glass bottle 生化/生理作用 Cell permeable: yes 警告 Toxicity: Standard Handling (A) 重悬 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C. Unstable in DMSO. 其他说明 Liu. Y., et al. 2012. Mol. Cancer Ther.11, 1672. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息
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