CAS 1218-35-5; 盐酸赛洛唑啉; 2-(4-tert-butyl-2,6-dimethylbenzyl)-2-imidazolin monohydrochloride

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货号

品牌

产品名称

规格

包装、参考价格

详情

X797940

MACKLIN

盐酸赛洛唑啉

10mM in DMSO

468元/1ml;

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储存：-20°C, 密封, 干燥

X0063

TCI

Xylometazoline Hydrochloride

>98.0%(HPLC)(N)

265元/1G; 690元/5G;

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基本信息

纯度/分析方法	>98.0%(HPLC)(N)
分子式/分子量	C₁₆H₂₄N₂・HCl = 280.84
外观与形状(20℃)	固体
Reaxys-RN	5164576
PubChem物质ID	87560989
SDBS (AIST Spectral DB)	52413
Merck Index (14)	10086
MDL编号	MFCD00238707

技术规格

Appearance	White to Almost white powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(with Total Nitrogen)	min. 98.0 %

安全信息

图形或危害标志
信号词	危险
危险性说明	H301 : 吞咽会中毒。
防范说明	P501 : 将内装物/容器送到批准的废物处理厂处理。 P270 : 使用本产品时不要进食、饮水或吸烟。 P264 : 作业后彻底清洗皮肤。 P301 + P310 + P330 : 如误吞咽：立即呼叫急救中心/医生。漱口。 P405 : 存放处须加锁。

相关法规

RTECS#

NJ2390000

运输信息

UN编号	UN2811
类别	6.1
包装类别	III
监管条件代码(*)

304079

J&K

Xylometazoline Hydrochloride

98%, 一种α-肾上腺素受体激动剂

228元/1G; 594元/5G;

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基本信息

分子式	C₁₆H₂₄N₂·HCl
分子量	280.84
MDL编码	MFCD00238707
Beilstein	5164576
Merck	14,10086
EINECS 编号	214-936-4
存储条件	Freezer -20℃

产品描述

Xylometazoline HCl 是α-adrenoceptor激动剂，常用作鼻血管收缩药，高效作用于α2B肾上腺素受体亚型，EC50为4 μM。

靶点（IC50 & Targe）

α1A-adrenergic receptor,80nM

α1B-adrenergic receptor,560nM

α1D-adrenergic receptor,450nM

α2A-adrenergic receptor,980nM

α2B-adrenergic receptor,1800nM

α2C-adrenergic receptor,220nM

体外研究

Xylometazoline是一种α肾上腺素激动剂，通常用作鼻血管收缩药，对α2B肾上腺素受体亚型具有最高的效力，EC50为99 μM。Xylometazoline与肾上腺素能受体亚型α1A，α1B，α1D，α2A，α2B，α2C结合，IC50分别为0.08，0.56，0.45，0.98，1.8，0.22μM。[1]

参考文献

[1] Haenisch B, Fundam Clin Pharmacol, 2010, 24(6), 729-739.

安全信息

图形或危害标志
提示语	Danger
危险说明	H301
防范说明	P301+P310
UN号码	2811
危险分类	6.1
包装等级	III
WGK	3
RTECS	NJ2390000

C46199

Alfa Aesar

Xylometazoline Hydrochloride

98%

2934元/5g; 12511元/25g;

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基本信息

Ref#
46199

分子式
C16H24N2.HCL

分子量
233.21

GHS危害和防范说明

Hazard Statements
H301 H318 H412

Precautionary Statements
P280 P305+P351+P338 P310

安全信息

危险等级
6.1

X6000

Sigma-Aldrich

Xylometazoline Hydrochloride

1369.05元/5 G; 4764.98元/25 G;

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产品说明

包装

5, 25 g in glass bottle

生化/生理作用

α-肾上腺素能受体激动剂；咪唑啉结合位点配体。

特点和优势

该化合物由 Novartis 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单，请单击此处。

基本信息

经验(实验)分子式	C₁₆H₂₄N₂ · HCl
分子量	280.84
EC 号	214-936-4
MDL编号	MFCD00238707
PubChem化学物质编号	24278781
NACRES	NA.77

产品性质

质量水平	200
创始人	Novartis
SMILES string	CC1=CC(C(C)(C)C)=CC(C)=C1CC2=NCCN2.Cl
InChI	1S/C16H24N2.ClH/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15;/h8-9H,6-7,10H2,1-5H3,(H,17,18);1H
InChI key	YGWFCQYETHJKNX-UHFFFAOYSA-N
Gene Information	human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

安全信息

象形图
警示用语：	Danger
危险声明	H301
预防措施声明	P301 + P310
危险分类	Acute Tox. 3 Oral
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Faceshields, Gloves

X0100000

Xylometazoline Hydrochloride

European Pharmacopoeia (EP) Reference Standard

1259.15元/ ;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

α-肾上腺素能受体激动剂；咪唑啉结合位点配体。

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₁₆H₂₄N₂ · HCl
分子量	280.84
MDL编号	MFCD00238707
PubChem化学物质编号	329830767
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	EDQM
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	CC1=CC(C(C)(C)C)=CC(C)=C1CC2=NCCN2.Cl
InChI	1S/C16H24N2.ClH/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15;/h8-9H,6-7,10H2,1-5H3,(H,17,18);1H
InChI key	YGWFCQYETHJKNX-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H301
预防措施声明	P264 - P270 - P301 + P310 - P405 - P501
危险分类	Acute Tox. 3 Oral
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

07297

Supelco

Xylometazoline Hydrochloride

analytical standard

1554.5元/100 MG;

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产品说明

一般描述

Xylometazoline hydrochloride is a derivative of imidazole, and a representative of the class of α1 agonists. It is commonly used in nasal decongestants, which works on the principle of constricting the blood vessels in the mucous membranes.

应用

Xylometazoline hydrochloride may be used as a reference standard in determining the xylometazoline hydrochloride content in samples of nasal drops using high performance liquid chromatography (HPLC).

生化/生理作用

α-肾上腺素能受体激动剂；咪唑啉结合位点配体。

基本信息

经验(实验)分子式	C₁₆H₂₄N₂ · HCl
分子量	280.84
EC 号	214-936-4
MDL编号	MFCD00238707
PubChem化学物质编号	329748399
NACRES	NA.24

产品性质

等级	analytical standard
质量水平	100
测定	≥98.0% (HPLC)
保质期	limited shelf life, expiry date on the label
technique(s)	HPLC: suitable gas chromatography (GC): suitable
杂质	≤1.0% water
application(s)	forensics and toxicology veterinary
格式	neat
SMILES string	CC1=CC(C(C)(C)C)=CC(C)=C1CC2=NCCN2.Cl
InChI	1S/C16H24N2.ClH/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15;/h8-9H,6-7,10H2,1-5H3,(H,17,18);1H
InChI key	YGWFCQYETHJKNX-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H301
预防措施声明	P301 + P310
危险分类	Acute Tox. 3 Oral
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

PHR2039

Supelco

Xylometazoline Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

2151.67元/500 MG;

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产品说明

一般描述

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

生化/生理作用

α-肾上腺素能受体激动剂；咪唑啉结合位点配体。

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAB6411 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式	C₁₆H₂₄N₂ · HCl
分子量	280.84
MDL编号	MFCD00238707
NACRES	NA.24

产品性质

质量水平	300
等级	certified reference material pharmaceutical secondary standard
CofA	current certificate can be downloaded
包装	pkg of 500 mg
格式	neat
药典可追溯性	traceable to BP 353 traceable to PhEur X0100000 traceable to USP 1721002
储存温度	2-8℃
SMILES string	CC1=CC(C(C)(C)C)=CC(C)=C1CC2=NCCN2.Cl
InChI	1S/C16H24N2.ClH/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15;/h8-9H,6-7,10H2,1-5H3,(H,17,18);1H
InChI key	YGWFCQYETHJKNX-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H301
预防措施声明	P301 + P330 + P331 + P310
危险分类	Acute Tox. 3 Oral
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

BP353

Xylometazoline Hydrochloride

British Pharmacopoeia (BP) Reference Standard

1861.35元/100 MG;

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产品说明

一般描述

生化/生理作用

α-肾上腺素能受体激动剂；咪唑啉结合位点配体。

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₁₆H₂₄N₂ · HCl
分子量	280.84
EC 号	214-936-4
MDL编号	MFCD00238707
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	BP
格式	neat
储存温度	2-8℃
SMILES string	CC1=CC(C(C)(C)C)=CC(C)=C1CC2=NCCN2.Cl
InChI	1S/C16H24N2.ClH/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15;/h8-9H,6-7,10H2,1-5H3,(H,17,18);1H
InChI key	YGWFCQYETHJKNX-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H301
预防措施声明	P301 + P330 + P331 + P310
危险分类	Acute Tox. 3 Oral
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

1721002

USP

Xylometazoline Hydrochloride

United States Pharmacopeia (USP) Reference Standard

3231.47元/250 MG;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

α-肾上腺素能受体激动剂；咪唑啉结合位点配体。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式	C₁₆H₂₄N₂ · HCl
分子量	280.84
MDL编号	MFCD00238707
PubChem化学物质编号	329751517
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	USP
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	CC1=CC(C(C)(C)C)=CC(C)=C1CC2=NCCN2.Cl
InChI	1S/C16H24N2.ClH/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15;/h8-9H,6-7,10H2,1-5H3,(H,17,18);1H
InChI key	YGWFCQYETHJKNX-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H301
预防措施声明	P301 + P330 + P331 + P310
危险分类	Acute Tox. 3 Oral
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable