CAS 1211565-08-0; n-[(1r,2r)-2-(1-哌啶基)环己基]-n′-[4-(三氟甲基)苯基]四酰胺; 3-{[(1r,2r)-2-(1-piperidinyl)cyclohexyl]amino}-4-{[4-(trifluoromethyl)phenyl]amino}-3-cyclobutene-1,2-dione

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CAS:

1211565-08-0

分子式:

C₂₂H₂₆F₃N₃O₂

分子量:

421.50

沸点:

497.4±55.0 °C

熔点:

250 °C

中文名称:

n-[(1r,2r)-2-(1-哌啶基)环己基]-n′-[4-(三氟甲基)苯基]四酰胺

n-[(1r,2r)-2-(1-piperidinyl)cyclohexyl]-n′-[4-(trifluoromethyl)phenyl]squaramide

英文名称:

3-{[(1r,2r)-2-(1-piperidinyl)cyclohexyl]amino}-4-{[4-(trifluoromethyl)phenyl]amino}-3-cyclobutene-1,2-dione

rawal squaramide organocatalyst

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

R906584

MACKLIN

3-[[(1R,2R)-2-(1-哌啶基)环己基]氨基]-4-[[4-(三氟甲基)苯基]氨基]-3-环丁烯-1,2-二酮

97%

324元/50mg;

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储存：2-8°C

07-1356

Strem

3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione

98%, (99% ee)

1485元/50mg;

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Technical Notes:

1.Macheal Addition- highly enantioselective Michael addition reaction of diphenyl phosphite to a range of nitroalkenes .

2.Hydrophosphonylation- diphenylphosphite has been successfully employed in a chiral Pudovik reaction with aldehydes, extending the generality of this asymmetric methodology.

3.Friedel-Crafts/Substitution Domino Reaction- Dihydroarylfuran skeletons are efficiently synthesized from (Z)- bromonitroalkenes and naphthol derivatives in good yields and excellent enantioselectivities

References:

1.Angew. Chem. Int. Ed., 2010, 49, 153-1 56.

2.Org. Biomol. Chem., 2014, 12, 1258-1264.

3.Angew. Chem. Commun., 2013, 49, 2001-2003.

Y24661

Alfa Aesar

3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(triflu

1403元/50mg; 2230元/100mg;

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基本信息

分子式
C22H26F3N3O2

分子量
421.46

728357

Sigma-Aldrich

N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoromethyl)phenyl]squaramide

95%

1323.98元/100 MG; 2640.95元/500 MG;

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产品说明

应用

It can act as a catalyst for the asymmetric tandem aza-Michael addition-protonation between 1-nitro cyclohexene and 4-methoxyaniline to form the corresponding α-arylamino-β-nitro cyclohexane in a 35:65 trans/cis mixture.
Catalyst for enantioselective Michael addition.

包装

Bottomless glass bottle. Contents are inside inserted fused cone.

基本信息

经验(实验)分子式	C₂₂H₂₆F₃N₃O₂
分子量	421.46
MDL编号	MFCD18827464
PubChem化学物质编号	329764393
NACRES	NA.22

产品性质

质量水平	100
测定	≥94.5% (HPLC) 95%
旋光性	[α]/D -42.0±2.0°, c = 1 in DMSO
杂质	≤2.0% pyridine
SMILES string	FC(F)(F)c1ccc(NC2=C(N[C@@H]3CCCC[C@H]3N4CCCCC4)C(=O)C2=O)cc1
InChI	1S/C22H26F3N3O2/c23-22(24,25)14-8-10-15(11-9-14)26-18-19(21(30)20(18)29)27-16-6-2-3-7-17(16)28-12-4-1-5-13-28/h8-11,16-17,26-27H,1-7,12-13H2/t16-,17-/m1/s1
InChI key	JRSCPJJNZMRAQS-IAGOWNOFSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H315 - H318 - H335
预防措施声明	P280 - P302 + P352 - P305 + P351 + P338 + P310
危险分类	Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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