CAS 1187020-80-9; 4-((6br,10as)-3-methyl-2,3,6b,9,10,10a-hexahydro-1h,7h-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl)-butan-1-one 4-methylbenzenesulfonate; lumateperone tosylate

CAS:

1187020-80-9

分子式:

C₃₁H₃₆FN₃O₄S

分子量:

565.7

中文名称:

4-((6br,10as)-3-methyl-2,3,6b,9,10,10a-hexahydro-1h,7h-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl)-butan-1-one 4-methylbenzenesulfonate

1-(4-fluorophenyl)-4-[(6br,10as)-3-methyl-2,3,6b,9,10,10a-hexahydro-1h-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7h)-yl]butan-1-one 4-methylbenzenesulfonate

英文名称:

lumateperone tosylate

iti-007

用途:

Lumateperone甲苯磺酸盐是5-HT 2A受体拮抗剂 (KI= 0.54 nM), 突触前D2受体的部分激动剂和突触后D2受体的拮抗剂 (KI= 32 nM)。

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货号

品牌

产品名称

规格

包装、参考价格

详情

T884160

MACKLIN

lumateperone Tosylate

≥99%

411元/5mg; 685元/10mg; 1165元/25mg; 1985元/50mg; 3367元/100mg; 5925元/250mg;

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储存：2-8℃
状态：白色到灰色固体

SML2866

Sigma-Aldrich

Lumateperone tosylate

≥98% (HPLC)

940.27元/10 MG; 3793.48元/50 MG;

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产品说明

生化/生理作用

Lumateperone tosylate (ITI-007) is an orally active, potent 5-HT2A antagonist, postsynaptic D2 antagonist, and serotonin transporter SERT inhibitor (K_i = 0.5, 32, 62 nM, respectively) with in vivo antipsychotic efficacy and no effect toward receptors associated with cognitive and metabolic side effects of antipsychotic drugs (e.g., H1, 5-HT2C, muscarinic). ITI-007 blocks DOI-induced headtwitch (ID₅₀ = 0.09 mg/kg, po.) and D-AMPH-induced hyperlocomotion in mice (ID₅₀ = 0.95 mg/kg, po.), while also acting as a partial agonist at presynaptic striatal D2 receptors.

基本信息

经验(实验)分子式	C₂₄H₂₈FN₃O · C₇H₈O₃S
分子量	565.70
MDL编号	MFCD29922434

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
旋光性	[α]/D -10 to -14, c = 1 in DMSO
颜色	white to very dark gray
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	O=C(C1=CC=C(F)C=C1)CCCN2CC[C@]([C@@]3([H])C2)([H])N4CCN(C)C5=C4C3=CC=C5.O=S(C6=CC=C(C)C=C6)(O)=O

安全信息

象形图
警示用语：	Warning
危险声明	H336 - H361f
预防措施声明	P202 - P261 - P271 - P280 - P304 + P340 + P312 - P308 + P313
危险分类	Repr. 2 - STOT SE 3
靶器官	Central nervous system
储存分类代码	11 - Combustible Solids
WGK	WGK 3