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CAS: 116649-85-5
分子式: C21H21FN2O4S
分子量: 416.47
英文名称: 
bay u 3405
用途: Ramatroban (BAY u 3405) is a thromboxane A2(TxA2) receptor antagonist with Ki value of 10 to 13 nM. It also antagonizes a newly identified PGD2 receptor, CRTh2 expressed on the inflammatory cells.
推荐供应商
货号品牌产品名称规格包装、参考价格详情
B873294MACKLINRamatroban99%71元/10mg;   展开
储存:-20℃
状态:白色到浅黄色到浅橙色粉末到晶体
R0144TCIRamatroban>95.0%(T)(HPLC)990元/10MG;   2990元/50MG;   展开

基本信息

纯度/分析方法>95.0%(T)(HPLC)
分子式/分子量C21H21FN2O4S = 416.47
外观与形状(20℃)固体
储存温度0-10℃
储存在惰性气体下存放于惰性气体之中
应避免的情况空气,加热
Reaxys-RN6773289
Merck Index (14)8100
MDL编号MFCD00887606

技术规格

AppearanceWhite to Light yellow to Light orange powder to crystal
Purity(HPLC)min. 95.0 area%
Purity(Neutralization titration)min. 95.0 %
Specific rotation+62.0 to +66.0 deg(C=1, methanol)

物性(参考值)

水溶性实际上不溶
溶解性(可溶于)甲醇,乙醇
溶解度(极微溶)二乙醚,正庚烷

安全信息

图形或危害标志
信号词警告
危险性说明H302 : 吞咽有害。
H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染:用水充分清洗。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服,清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激:求医/就诊。
P301 + P312 + P330 : 如误吞咽:如感觉不适,呼叫急救中心/医生。漱口。

相关法规

RTECS#FE6278500
R0531Sigma-AldrichRamatroban≥98% (HPLC), solid1804.21元/5 MG;   6869.89元/25 MG;   展开

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Ramatroban is used for the treatment of allergic rhinitis as an antagonist of the thromboxane receptor. It is also an antagonist of the DP2 receptor with IC50 values of 100-170 nM. It is more potent at the DP2 receptor than the TP receptor by 4-5 fold. It is therefore a useful tool for the elucidation of PGD2/DP2 function in eosinophils, basophils, and other cells of the TH2 cell-type.
Ramatroban aids in the reduction of myocardial ischemia-reperfusion injury, lipopolysaccharide-induced shock, and vagal neuroeffector transmission in the tracheal smooth muscle of experimental models. In addition, it also suppresses allergen and IgE antibody-mediated skin and nasal reactions and eosinophilia in animal models with asthma.

特点和优势

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式C21H21FN2O4S
分子量416.47
MDL编号MFCD00887606
PubChem化学物质编号329823986
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
颜色 white
溶解性DMSO: ≥40 mg/mL
H2O: insoluble
创始人Bayer
储存温度2-8℃
SMILES stringOC(=O)CCn1c2CC[C@H](Cc2c3ccccc13)NS(=O)(=O)c4ccc(F)cc4
InChI1S/C21H21FN2O4S/c22-14-5-8-16(9-6-14)29(27,28)23-15-7-10-20-18(13-15)17-3-1-2-4-19(17)24(20)12-11-21(25)26/h1-6,8-9,15,23H,7,10-13H2,(H,25,26)/t15-/m1/s1
InChI keyLDXDSHIEDAPSSA-OAHLLOKOSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H315 - H319 - H335
预防措施声明P302 + P352 - P305 + P351 + P338
危险分类Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
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