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CAS: 1136-45-4
分子式: C11H9NO3
分子量: 203.20
熔点: 192-194℃
中文名称: 
5-甲基-3-苯基-4-异恶唑酸
5-甲基-3-苯基异恶唑-4-甲酸
5-甲基-3-苯基-4-异噁唑酸
英文名称: 
5-methyl-3-phenyl-isoxazole-4-carboxylic aci
3-phenyl-5-methylisoxazol-4-carbonsaeure
5-methyl-3-phenyl-4-isoxazolecarboxylic aci
5-methyl-3-phenylisoxazole-4-carboxylic acid
5-Methyl-3-phenyl-4-iso-xazolic acid
性质描述: 该品熔点192-193℃。
生产方法: 由苯甲氯肟与乙酰乙酸乙酯环合后水解而得。将乙酰乙酸乙酯与苯甲氯肟乙醇溶液搅拌混合,冷却至0℃,加氢氧化钠溶液调至pH为7-8,因反应放热,需冷却保持在10℃左右。再继续调至pH为9-9.5,在10℃左右反应4h。再加氢氧化钠溶液,升温蒸出乙醇直到110℃,冷却、加水,搅拌回流3h。用盐酸酸化至pH=6,除去油层后加活性炭脱色,过滤,滤液用盐酸调至pH=3.8。过滤,滤饼洗至中性,真空干燥,得5-甲基-3-苯基-4-异噁唑酸。
用途: 用于苯唑青霉素钠的生产。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
M833699MACKLIN5-甲基-3-苯基异恶唑-4-羧酸98%159元/5g;   288元/10g;   655元/25g;   2389元/100g;   展开
储存:室温,密封,干燥
L01142Alfa Aesar5-Methyl-3-phenylisoxazole-4-carboxylic acid99%1001元/25g;   3262元/100g;   展开

基本信息

MDL
MFCD00003153

EINECS
214-497-9

分子式
C11H9NO3

分子量
203.20

熔点
191-193°

形态
Powder

Beilstein
164939

GHS危害和防范说明

GHS符号

Hazard Statements
H302-H313
Harmful if swallowed.May be harmful in contact with skin.

Precautionary Statements
P264-P270-P301+P312a-P330-P501a
Wash thoroughly after handling.Do not eat, drink or smoke when using this product.Do not eat, drink or smoke when using this product.Rinse mouth.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
22
Harmful if swallowed.

安全等级
36
Wear suitable protective clothing.

欧盟危险品标志

RTECS
NY2750000

TSCA

PHR2496SupelcoOxacillin Related Compound CPharmaceutical Secondary Standard; Certified Reference Material7687.08元/50 MG;   展开

产品说明

一般描述

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

基本信息

经验(实验)分子式C11H9NO3
分子量203.19
MDL编号MFCD00003153

产品性质

等级certified reference material
pharmaceutical secondary standard
形式powder
包装pkg of 50 mg
mp192-194 ℃ (lit.)
药典可追溯性traceable to USP 1481044
储存温度2-30℃
SMILES stringCc1onc(-c2ccccc2)c1C(O)=O
InChI1S/C11H9NO3/c1-7-9(11(13)14)10(12-15-7)8-5-3-2-4-6-8/h2-6H,1H3,(H,13,14)
InChI keyPENHKTNQUJMHIR-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
1481044USPOxacillin Related Compound CUnited States Pharmacopeia (USP) Reference Standard10218.8元/15 MG;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C11H9NO3
分子量203.19
MDL编号MFCD00003153
PubChem化学物质编号329750628
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
mp192-194 ℃ (lit.)
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringCc1onc(-c2ccccc2)c1C(O)=O
InChI1S/C11H9NO3/c1-7-9(11(13)14)10(12-15-7)8-5-3-2-4-6-8/h2-6H,1H3,(H,13,14)
InChI keyPENHKTNQUJMHIR-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
055275Fluorochem5-Methyl-3-phenyl-isoxazole-4-carboxylic acid98%220元/1g;   418元/5g;   968元/25g;   2728元/100g;   展开

基本信息

CAS Number1136-45-4
MDL NumberMFCD00003153

安全信息

图形或危害标志
危险性说明 H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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