CAS 113-92-8; 扑尔敏; 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-pyridin maleate (1:1)

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货号

品牌

产品名称

规格

包装、参考价格

详情

C797937

MACKLIN

扑尔敏

10mM in DMSO

209元/1ml;

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储存：-20°C

C838457

MACKLIN

扑尔敏

99%

52元/5g; 85元/25g; 228元/100g; 856元/500g;

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储存：室温
状态：白色到灰白色晶体粉末

C0873

TCI

Chlorpheniramine Maleate

>99.0%(T)(HPLC)

605元/25G;

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基本信息

纯度/分析方法	>99.0%(T)(HPLC)
分子式/分子量	C₁₆H₁₉ClN₂・C₄H₄O₄ = 390.86
外观与形状(20℃)	固体
Reaxys-RN	4117059
PubChem物质ID	87565931
Merck Index (14)	2180
MDL编号	MFCD00069225

技术规格

Appearance	White to Almost white powder to crystal
Purity(HPLC)	min. 99.0 %(excluding counter anion)
Purity(Nonaqueous Titration)	min. 99.0 %
Melting point	132.0 to 136.0 ℃
Solubility in Water	almost transparency

物性(参考值)

熔点	135 ℃
水溶性	可溶

安全信息

图形或危害标志
信号词	危险
危险性说明	H302 : 吞咽有害。 H361 : 怀疑对生育能力或胎儿造成伤害。 H370 : 会损害器官。 H372 : 长期或反复接触会对器官造成损害。
防范说明	P501 : 将内装物/容器送到批准的废物处理厂处理。 P260 : 不要吸入粉尘/ 烟/ 气体/ 烟雾/ 蒸气/ 喷雾。 P270 : 使用本产品时不要进食、饮水或吸烟。 P202 : 在阅读并明了所有安全措施前切勿搬动。 P201 : 使用前取得专用说明。 P264 : 作业后彻底清洗皮肤。 P280 : 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P308+P311 : 如接触到或有疑虑：呼叫急救中心/医生。 P301 + P312 + P330 : 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口。 P405 : 存放处须加锁。

相关法规

RTECS#

US6475000

153710

J&K

Chlorpheniramine Maleate

99%, 一种组胺H1受体拮抗剂

512元/25G; 1536元/100G;

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基本信息

分子式	C₂₀H₂₃ClN₂O₄
分子量	390.86
熔点	130-135
MDL编码	MFCD00069225
Beilstein	4117059
Merck	142180
EINECS 编号	204-037-5

产品描述

Chlorpheniramine Maleate是一种组胺H1受体拮抗剂，IC50为12 nM。

靶点（IC50 & Targe）

H1 receptor,12nM

体外研究

Chlorpheniramine作用于豚鼠回肠，抑制组胺诱导的收缩，IC50为12 nM。[1] Chlorpheniramine作用于豚鼠大脑皮层，抑制[3H]mepyramine 结合到组胺组胺H1受体上，IC50为 8.8 nM。[2] Chlorpheniramine抑制 MCF-7, MDA-MB 231,和Ehrlich细胞增殖，这种作用存在剂量反应性，且250 μM时，显著降低鸟氨酸脱羧酶mRNA 翻译，降低50%-70%。[3] Chlorpheniramine从在CHO 细胞中表达的人组胺受体亚型1中置换[3H]pyrilamin，IC50为66 nM。Chlorpheniramine 作用于P. falciparum的 CQS品种 (D6)和MDR品种(Dd2)，具有抗疟疾活性，IC50分别为61.2 uM 和 3.9 uM。Chlorpheniramine 作用于伴刀豆球蛋白A-诱导的小鼠脾淋巴细胞增殖，具有毒性，IC50为33.4 μM。[4] Chlorpheniramine 作用于人唾液腺细胞，显著抑制组胺诱导的Ca2+i增高，这种作用具有浓度依赖性，IC50为128 nM，而作用于Carbachol-诱导的Ca2+i增高效果弱点，IC50为43.9 μM。[5]

体内研究

Chlorpheniramine口服处理给药豚鼠，抑制组胺诱导的死亡，ED50为0.17 mg/kg。[1] Chlorpheniramine按 10 mg/kg剂量口服处理卵清蛋白活性皮肤过敏刺激的BALB/c小鼠和皮下注射组胺的ICR小鼠，显著抑制短期刮伤，但是作用于NC/Nga小鼠，对长期刮伤则无效果，而Dexamethasone或Tacrolimus却有效果。[6] Chlorpheniramine 按20 mg/kg剂量处理大鼠，显著废除束缚应激诱导的快速眼动睡眠(REM 睡眠)的提高，因为阻断产生 REM 睡眠的组胺或胆碱机制。 [7]

激酶实验

H1-抗组胺活性:

从豚鼠中分离的回肠片段 (1 cm)悬浮在含Tyrode溶液 (通风环境, 32oC)的器官浴槽中。使用等渗收缩传感器测量对组胺(0.54 μM)的收缩反应。在器官浴槽中加入一系列浓度的Chlorpheniramine，温育5分钟，然后加入组胺。通过概率法测定Chlorpheniramine的IC50值。

细胞实验

Cell lines: MCF-7, MDA-MB 231, 和 Ehrlich

Concentrations: 溶于水，终浓度为～500 μM

Incubation Time: 48 小时

Method: 使用不同浓度 Chlorpheniramine处理细胞48小时。冲洗细胞，分离，使用Coulter计数器计数，测定细胞生长。

(Only for Reference)

动物实验

Animal Models: 患过敏性皮炎的雄性NC/Nga小鼠,雄性 ICR 小鼠，和雌性 BALB/c 小鼠

Formulation: 悬浮在 1% (v/v) Tween-80中

Dosages: 10 mg/kg

Administration: 口服处理

(Only for Reference)

参考文献

[1] Iemura R, et al. J Med Chem, 1986, 29(7), 1178-1183.

[2] Sleevi MC, et al. J Med Chem, 1991, 34(4), 1314-1328.

[3] Medina MA, et al. Breast Cancer Res Treat, 1995, 35(2), 187-194.

[4] Kelly JX, et al. Antimicrob Agents Chemother, 2007, 51(11), 4133-4140.

[5] Kim JH, et al. J Pharmacol Exp Ther, 2009, 330(2), 403-412.

[6] Takano N, et al. Eur J Pharmacol, 2003, 471(3), 223-228.

安全信息

图形或危害标志
提示语	Warning
危险说明	H301
防范说明	P301+P310
UN号码	2811
危险分类	6.1
包装等级	III
RTECS	US6503000
TSCA	是

B25238

Alfa Aesar

Chlorpheniramine Maleate

99%

893元/5g; 2074元/25g;

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应用
An antihistaminic agent

基本信息

MDL
MFCD00069225

EINECS
204-037-5

分子式
C₂₀H₂₃ClN₂O₄

分子量
390.86

熔点
130-135°

灵敏度
Ambient temperatures.

形态
Crystals

GHS危害和防范说明

GHS符号

Hazard Statements
H302
Harmful if swallowed.

Precautionary Statements
P264-P270-P301+P312a-P330-P501a
Wash thoroughly after handling.Do not eat, drink or smoke when using this product.Do not eat, drink or smoke when using this product.Rinse mouth.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
22
Harmful if swallowed.

安全等级
36
Wear suitable protective clothing.

欧盟危险品标志

RTECS
US6503000

TSCA
是

R12056

Alfa Aesar

Chlorpheniramine maleate,1000ppm

440元/1ml;

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安全信息

危险等级
3

R11013

Alfa Aesar

Chlorpheniramine maleate Standard solution

100ppm

210元/1ml;

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安全信息

危险等级
3

C1800000

Chlorphenamine maleate

European Pharmacopoeia (EP) Reference Standard

1572.27元/ ;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

H ₁ 组胺受体拮抗剂。

包装

Unit quantity: 20 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₁₆H₁₉ClN₂ · C₄H₄O₄
分子量	390.86
MDL编号	MFCD00069225
PubChem化学物质编号	329774908
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	EDQM
mp	130-135 ℃ (lit.)
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	CN(C)CCC(C1=CC=C(Cl)C=C1)C2=NC=CC=C2.O=C(/C=C\C(O)=O)O
InChI	1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI key	DBAKFASWICGISY-BTJKTKAUSA-N
Gene Information	human ... HRH1(3269)

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P301 + P312 + P330
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

C3025

Sigma-Aldrich

(±)-Chlorpheniramine maleate salt

≥99% (perchloric acid titration)

458.66元/5 G; 913.67元/25 G; 2289.97元/100 G;

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产品说明

一般描述

马来酸氯苯吡胺(CPM)/(3-(4-氯苯基)-N，N-二甲基-3-吡啶-2-基-丙烷-1-胺是一种烷基胺抗组胺药。

应用

(±)-马来酸氯苯吡胺已被用于：

作为H1受受体拮抗剂用于测定受体功能
阻断化合物48/80对血浆IGF-I的作用
作为标准品通过配有电位差计的顺序进样器用于快速感应和测定

包装

5, 25, 100 g in glass bottle

生化/生理作用

马来酸氯苯吡胺(CPM)可预防鼻炎和荨麻疹。它常用于治疗多种过敏症状。这种抗组胺药也用于小动物的兽医治疗。
H ₁ 组胺受体拮抗剂。

特点和优势

该化合物由Bayer开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。

基本信息

经验(实验)分子式	C₁₆H₁₉ClN₂ · C₄H₄O₄
分子量	390.86
EC 号	204-037-5
MDL编号	MFCD00069225
PubChem化学物质编号	24277767
NACRES	NA.77

产品性质

质量水平	100
测定	≥99% (perchloric acid titration)
mp	130-135 ℃ (lit.)
创始人	Bayer
SMILES string	CN(C)CCC(C1=CC=C(Cl)C=C1)C2=NC=CC=C2.O=C(/C=C\C(O)=O)O
InChI	1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI key	DBAKFASWICGISY-BTJKTKAUSA-N
Gene Information	human ... HRH1(3269)

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P301 + P312 + P330
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

1123000

USP

Chlorpheniramine Maleate

United States Pharmacopeia (USP) Reference Standard

2633.96元/125 MG;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

H ₁ 组胺受体拮抗剂。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式	C₁₆H₁₉ClN₂ · C₄H₄O₄
分子量	390.86
MDL编号	MFCD00069225
PubChem化学物质编号	329749337
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	USP
mp	130-135 ℃ (lit.)
application(s)	pharmaceutical (small molecule)
格式	neat
SMILES string	CN(C)CCC(C1=CC=C(Cl)C=C1)C2=NC=CC=C2.O=C(/C=C\C(O)=O)O
InChI	1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI key	DBAKFASWICGISY-BTJKTKAUSA-N
Gene Information	human ... HRH1(3269)

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P301 + P312 + P330
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

PHR1016

Supelco

Chlorpheniramine Maleate

Pharmaceutical Secondary Standard; Certified Reference Material

1359.83元/500 MG;

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产品说明

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Chlorpheniramine Maleate is an H₁-receptor antagonist drug grouped under the class of antihistaminic compounds.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Chlorpheniramine Maleate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.

生化/生理作用

H ₁ 组胺受体拮抗剂。

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC0771 in the slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式	C₁₆H₁₉ClN₂ · C₄H₄O₄
分子量	390.86
EC 号	204-037-5
MDL编号	MFCD00069225
PubChem化学物质编号	329823047
NACRES	NA.24

产品性质

质量水平	300
等级	certified reference material pharmaceutical secondary standard
CofA	current certificate can be downloaded
technique(s)	HPLC: suitable gas chromatography (GC): suitable
mp	130-135 ℃ (lit.)
application(s)	pharmaceutical (small molecule)
格式	neat
药典可追溯性	traceable to BP 81 traceable to PhEur C1800000 traceable to USP 1123000
储存温度	2-30℃
SMILES string	CN(C)CCC(C1=CC=C(Cl)C=C1)C2=NC=CC=C2.O=C(/C=C\C(O)=O)O
InChI	1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI key	DBAKFASWICGISY-BTJKTKAUSA-N
Gene Information	human ... HRH1(3269)

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P301 + P312 + P330
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

BP081

Chlorphenamine maleate

British Pharmacopoeia (BP) Reference Standard

1295.6元/100 MG;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

H ₁ 组胺受体拮抗剂。

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₁₆H₁₉ClN₂ · C₄H₄O₄
分子量	390.86
EC 号	204-037-5
MDL编号	MFCD00069225

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	BP
mp	130-135 ℃ (lit.)
格式	neat
储存温度	2-8℃
SMILES string	CN(C)CCC(C1=CC=C(Cl)C=C1)C2=NC=CC=C2.O=C(/C=C\C(O)=O)O
InChI	1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI key	DBAKFASWICGISY-BTJKTKAUSA-N
Gene Information	human ... HRH1(3269)

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P301 + P312 + P330
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable