CAS 112809-51-5; 来曲唑; letrozole

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货号

品牌

产品名称

规格

包装、参考价格

详情

C46319

Alfa Aesar

Letrozole

5194元/1g;

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基本信息

Ref#
46319

分子式
C17H11N5

分子量
1066.20

GHS危害和防范说明

Hazard Statements
H302 H312 H315 H319 H332 H362

Precautionary Statements
P301+P330+P331 P312 P302+P352 P304+P340 P337+P313 P280 P263

PHR1540

Supelco

Letrozole

Pharmaceutical Secondary Standard; Certified Reference Material

1596.92元/1 G;

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产品说明

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Letrozole is used for the treatment of breast cancer in hormone-dependent postmenopausal patients. The drug works by blocking the synthesis of estrogen, a causative agent for cancer.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Letrozole may be used as a pharmaceutical reference standard for the determination of the analyte in biological/environmental samples and pharmaceutical formulations by various chromatography techniques.

生化/生理作用

来曲唑是第三代非甾体芳香酶抑制剂。它是芳香酶系统的竞争性抑制剂，因此可抑制雄激素向雌激素转化。来曲唑通过竞争性结合到该酶的细胞色素P450亚基的血红素上而抑制芳香酶，导致所有组织中雌激素的生物合成减少。

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA4186 in the slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式	C₁₇H₁₁N₅
分子量	285.30
MDL编号	MFCD00866241
PubChem化学物质编号	329823451
NACRES	NA.24

产品性质

质量水平	300
等级	certified reference material pharmaceutical secondary standard
CofA	current certificate can be downloaded
包装	pkg of 1 g
technique(s)	HPLC: suitable gas chromatography (GC): suitable
application(s)	pharmaceutical (small molecule)
格式	neat
药典可追溯性	traceable to PhEur Y0000685 traceable to USP 1356971
储存温度	2-30℃
SMILES string	N#CC(C=C1)=CC=C1C(N2C=NC=N2)C3=CC=C(C#N)C=C3
InChI	1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H
InChI key	HPJKCIUCZWXJDR-UHFFFAOYSA-N
Gene Information	human ... CYP19A1(1588)

安全信息

象形图
警示用语：	Warning
危险声明	H361fd - H373
预防措施声明	P202 - P260 - P280 - P308 + P313 - P405 - P501
危险分类	Repr. 2 - STOT RE 2
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

L6545

Sigma-Aldrich

Letrozole

≥98% (HPLC)

649.66元/10 MG; 2716.78元/50 MG;

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产品说明

应用

来曲唑已用于：

在类器官生长试验中测定其抑制力(48)
研究类固醇受体共激活因子1(SRC-1)介导的海马PSD-95内源性雌激素调节作用(49)
研究其对肿瘤诱导的痛觉过敏的作用 (50)
对大鼠进行激素干预(51)研究其对脂质运载蛋白-2(Lcn2)的作用(52)研究其对机械痛觉过敏和芳香化酶表达的作用(53)

包装

10, 50 mg in glass bottle

生化/生理作用

来曲唑是一种佐剂，可用于治疗乳腺癌。
来曲唑是第三代非甾体芳香酶抑制剂。它是芳香酶系统的竞争性抑制剂，因此可抑制雄激素向雌激素转化。来曲唑通过竞争性结合到该酶的细胞色素P450亚基的血红素上而抑制芳香酶，导致所有组织中雌激素的生物合成减少。

特点和优势

该化合物是由 Novartis开发。浏览其他医药开发的化合物和已批准的药物/候选药物清单，请点击此处。
该化合物是受体分类及信号转导手册上核受体(类固醇)页面上的特色化合物。想要浏览手册的其他页面，请单击此处。

基本信息

经验(实验)分子式	C₁₇H₁₁N₅
分子量	285.30
MDL编号	MFCD00866241
PubChem化学物质编号	329817641

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to off-white
溶解性	DMSO: >50 mg/mL
创始人	Novartis
储存温度	2-8℃
SMILES string	N#CC(C=C1)=CC=C1C(N2C=NC=N2)C3=CC=C(C#N)C=C3
InChI	1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H
InChI key	HPJKCIUCZWXJDR-UHFFFAOYSA-N
Gene Information	human ... CYP19A1(1588)

安全信息

象形图
警示用语：	Warning
危险声明	H361fd - H373
预防措施声明	P202 - P260 - P280 - P308 + P313 - P405 - P501
危险分类	Repr. 2 - STOT RE 2
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

BP1234

Letrozole

British Pharmacopoeia (BP) Reference Standard

2235.38元/100 MG;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₁₇H₁₁N₅
分子量	285.30
MDL编号	MFCD00866241

产品性质

质量水平	100
manufacturer/tradename	BP
储存温度	2-8℃
SMILES string	N#CC(C=C1)=CC=C1C(N2C=NC=N2)C3=CC=C(C#N)C=C3
InChI	1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H
InChI key	HPJKCIUCZWXJDR-UHFFFAOYSA-N
Gene Information	human ... CYP19A1(1588)

安全信息

象形图
警示用语：	Warning
危险声明	H361fd - H373
预防措施声明	P202 - P260 - P280 - P308 + P313 - P405 - P501
危险分类	Repr. 2 - STOT RE 2
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable