| CAS: | 1127442-82-3 | |
| 分子式: | C25H19N3O3 | |
| 分子量: | 409.44 | |
| 中文名称: |
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| 英文名称: |
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| 用途: | IWR-1-endo是一种Wnt通路抑制剂，在表达 Wnt3A 的 L-细胞中IC50为180 nM，诱导Axin2蛋白水平，并通过稳定Axin骨架破坏复合体来促进β-catenin磷酸化。IWR-1 和XAV939作为Wnt通路的可逆抑制剂，在体内外具有相似的药理作用，IWR-1通过与Axin相互作用而发挥效果,而XAV939直接与TNKS结合。[1] |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||
| I796098 | MACKLIN | IWR-1-endo | 10mM in DMSO | 326元/1ml; | 咨询 | ||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||
| I872800 | MACKLIN | IWR-1-endo | 99% | 358元/5mg; 946元/25mg; 3485元/100mg; | 咨询 | ||||||||||||||||||||||||||
储存：-20℃ 状态：白色到棕色粉末到晶体 | |||||||||||||||||||||||||||||||
| 1189408 | J&K | IWR-1 | 98%, 是端锚聚合酶抑制剂, 抑制Wnt/β-catenin信号传导途径 | 380元/5MG; 680元/10MG; | 咨询 | ||||||||||||||||||||||||||
基本信息
产品描述 IWR-1-endo是一种Wnt通路抑制剂，在表达 Wnt3A 的 L-细胞中IC50为180 nM，诱导Axin2蛋白水平，并通过稳定Axin骨架破坏复合体来促进β-catenin磷酸化。 靶点（IC50 & Targe） Wnt,180nM 体外研究 IWR-1 和XAV939作为Wnt通路的可逆抑制剂，在体内外具有相似的药理作用，IWR-1通过与Axin相互作用而发挥效果,而XAV939直接与TNKS结合。[1] 参考文献 [1] Lu J, et al. Bioorg Med Chem Lett, 2009, 19(14), 3825-3827. | |||||||||||||||||||||||||||||||
| 5.04462 | Sigma-Aldrich | InSolution Wnt Antagonist I, IWR-1-endo-CAS 1127442-82-3-Calbiochem | 1129.94元/5 MG; | 咨询 | |||||||||||||||||||||||||||
产品说明 一般描述 A cell-permeable p-imidobenzamidoquinoline, endo-diastereomer that is shown to inhibit the activity of TNKS1/PARP5a and TNKS2/PARP5b in in vitro auto-PARsylation assays (IC50 = 131 and 56 nM, respectively) and effectively suppress Wnt-stimulated transcription activity in L-Wnt-STF-based reporter assays (IC50 = 180 nM), while exhibiting little activity against PARP1 or PARP2 (IC50 >18.75 µM). Although both IWR-1-endo and XAV939 (Tankyrase1/2 Inhibitor; >Cat. No. 575545) act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects both in vitro and in vivo, IWR-1-endo exerts its effect via interaction with Axin, while XAV939 binds TNKS directly. 生化/生理作用 Cell permeable: yes 包装 Packaged under inert gas 警告 Toxicity: Irritant (B) 外形 A 25 mM (5 mg/489 µL) solution of Wnt Antagonist I, IWR-1-endo (Cat. No. 681669) in DMSO. 重悬 Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. 其他说明 Wang, H., et al. 2011. ACS Chem. Biol.6, 192. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息
产品性质
安全信息
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