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CAS: 111470-99-6
分子式: C20H25ClN2O5·C6H5SO3H
分子量: 567.05
中文名称: 
马来酸氨氯地平
英文名称: 
Amlodipine maleate
3,5-pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)- 1,
4-dihydro-6-methyl-, 3-ethyl-5-methyl ester, monobenzenesulfonate
amlodipine benzenesulfonate
amlodipine besilate
amlodipine besylate
norvasc
uk 48340-26
推荐供应商
货号品牌产品名称规格包装、参考价格
A797825MACKLIN苯磺酸氨氯地平10mM in DMSO350元/1ml;   咨询
储存：-20°C
A832889MACKLIN苯磺酸氨氯地平98%42元/1g;   76元/5g;   176元/25g;   642元/100g;   咨询
储存：室温,干燥,密封
状态：白色到灰白色粉末
A2353TCIAmlodipine Besylate>98.0%(HPLC)(N)650元/1G;   2250元/5G;   咨询

基本信息

纯度/分析方法>98.0%(HPLC)(N)
分子式/分子量C20H25ClN2O5・C6H5SO3H = 567.05
外观与形状(20℃)固体
相关CAS RN88150-42-9
Reaxys-RN8378713
PubChem物质ID125307717
SDBS (AIST Spectral DB)52867
Merck Index (14)491
MDL编号MFCD00887594

技术规格

AppearanceWhite to Dark green powder to crystal
Purity(HPLC)min. 98.0 %(total of isomer)
Purity(with Total Nitrogen)min. 98.0 %

物性(参考值)

熔点200 ℃(dec.)
水溶性微溶

安全信息

图形或危害标志
信号词警告
危险性说明H302 : 吞咽有害。
H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染：用水充分清洗。
P337 + P313 : 如仍觉眼刺激：求医/就诊。
P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激：求医/就诊。
P301 + P312 + P330 : 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口。

相关法规

RTECS#US7967700
950637J&KAmlodipine Besylate98%150元/20MG;   咨询

基本信息

分子式C26H31ClN2O8S
分子量567.05
MDL编码MFCD00887594
R11053Alfa AesarAmlodipine besilate Standard solution100ppm1676元/1ml;   咨询

安全信息

危险等级
3

R12089Alfa AesarAmlodipine besilate,1000ppm3520元/1ml;   咨询

安全信息

危险等级
3

PHR1185SupelcoAmlodipine BesylatePharmaceutical Secondary Standard; Certified Reference Material1359.83元/1 G;   咨询

产品说明

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Amlodipine besylate is a calcium channel blocker, which inhibits the trans membrane influx of calcium ions into vascular smooth muscles and cardiac muscle. It belongs to the dihydropyridine family. It is used in combination with atorvastatin calcium to treat vasospastic angina, chronic stable angina, hypertension, in elevated serum triglyceride levels, primary dysbetalipoproteinemia.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Amlodipine besylate may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using different chromatography techniques and spectrophotometric technique.

生化/生理作用

氨氯地平是一种 L 型钙通道阻滞剂。氨氯地平属于一类心血管药物，作用于 Ca V 1 或 L 型的电压门控钙通道。氨氯地平还具有降压和抗心绞痛作用。其活性主要存在于 (-)-异构体中。氨氯地平抑制人表皮样癌细胞 A431 的生长，对雄性大鼠有抗生殖作用。

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC0717 in the slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式C20H25ClN2O5 · C6H5SO3H
分子量567.05
MDL编号MFCD00887594
PubChem化学物质编号329823196
NACRESNA.24

产品性质

质量水平300
等级certified reference material
pharmaceutical secondary standard
CofAcurrent certificate can be downloaded
technique(s)HPLC: suitable
gas chromatography (GC): suitable
application(s)pharmaceutical (small molecule)
格式neat
药典可追溯性traceable to PhEur Y0000049
traceable to USP 1029501
储存温度2-8℃
SMILES stringOS(=O)(=O)c1ccccc1.CCOC(=O)C2=C(COCCN)NC(C)=C(C2c3ccccc3Cl)C(=O)OC
InChI1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)
InChI keyZPBWCRDSRKPIDG-UHFFFAOYSA-N
Gene Informationhuman ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779)

安全信息

象形图GHS07
警示用语：Warning
危险声明H302
预防措施声明P264 - P270 - P301 + P312 - P501
危险分类Acute Tox. 4 Oral
储存分类代码11 - Combustible Solids
WGKWGK 3
Y0000049Amlodipine BesylateEuropean Pharmacopoeia (EP) Reference Standard1572.27元/ ;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

氨氯地平是一种 L 型钙通道阻滞剂。氨氯地平属于一类心血管药物，作用于 Ca V 1 或 L 型的电压门控钙通道。氨氯地平还具有降压和抗心绞痛作用。其活性主要存在于 (-)-异构体中。氨氯地平抑制人表皮样癌细胞 A431 的生长，对雄性大鼠有抗生殖作用。

包装

Unit quantity: 150 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C20H25ClN2O5 · C6H5SO3H
分子量567.05
MDL编号MFCD00887594
PubChem化学物质编号329830828
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringOS(=O)(=O)c1ccccc1.CCOC(=O)C2=C(COCCN)NC(C)=C(C2c3ccccc3Cl)C(=O)OC
InChI1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)
InChI keyZPBWCRDSRKPIDG-UHFFFAOYSA-N
Gene Informationhuman ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779)

安全信息

象形图GHS07
警示用语：Warning
危险声明H302
预防措施声明P264 - P270 - P301 + P312 - P501
危险分类Acute Tox. 4 Oral
储存分类代码11 - Combustible Solids
WGKWGK 3
Y0001067Amlodipine for peak identificationEuropean Pharmacopoeia (EP) Reference Standard1572.27元/ ;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

氨氯地平是一种 L 型钙通道阻滞剂。氨氯地平属于一类心血管药物，作用于 Ca V 1 或 L 型的电压门控钙通道。氨氯地平还具有降压和抗心绞痛作用。其活性主要存在于 (-)-异构体中。氨氯地平抑制人表皮样癌细胞 A431 的生长，对雄性大鼠有抗生殖作用。

包装

Unit quantity: 10 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C20H25ClN2O5 · C6H5SO3H
分子量567.05
MDL编号MFCD00887594
PubChem化学物质编号329831246
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringOS(=O)(=O)c1ccccc1.CCOC(=O)C2=C(COCCN)NC(C)=C(C2c3ccccc3Cl)C(=O)OC
InChI1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)
InChI keyZPBWCRDSRKPIDG-UHFFFAOYSA-N
Gene Informationhuman ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779)

安全信息

象形图GHS07
警示用语：Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
A5605Sigma-AldrichAmlodipine Besylate≥98% (HPLC)2167.63元/10 MG;   6580.76元/50 MG;   咨询

产品说明

应用

苯磺酸氨氯地平是一种 L 型钙通道阻滞剂，可用于治疗心绞痛和高血压。氨氯地平还可抑制人表皮样癌细胞 A431 的生长，并对雄性大鼠具有抗生殖作用。

包装

10, 50 mg in glass bottle

生化/生理作用

氨氯地平是一种 L 型钙通道阻滞剂。氨氯地平属于一类心血管药物，作用于 Ca V 1 或 L 型的电压门控钙通道。氨氯地平还具有降压和抗心绞痛作用。其活性主要存在于 (-)-异构体中。氨氯地平抑制人表皮样癌细胞 A431 的生长，对雄性大鼠有抗生殖作用。

特点和优势

该化合物由 Pfizer 开发。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表， 点击这里 。
该化合物出现在《受体分类和信号转导手册》的 钙离子通道 页面。要浏览其他手册页， 单击此处 。

基本信息

经验(实验)分子式C20H25ClN2O5 · C6H5SO3H
分子量567.05
MDL编号MFCD00887594
PubChem化学物质编号24890999
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white
溶解性DMSO: ≥20 mg/mL
创始人Pfizer
SMILES stringOS(=O)(=O)c1ccccc1.CCOC(=O)C2=C(COCCN)NC(C)=C(C2c3ccccc3Cl)C(=O)OC
InChI1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)
InChI keyZPBWCRDSRKPIDG-UHFFFAOYSA-N
Gene Informationhuman ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779)

安全信息

象形图GHS07
警示用语：Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Faceshields, Gloves
1029501USPAmlodipine BesylateUnited States Pharmacopeia (USP) Reference Standard3231.47元/350 MG;   咨询

产品说明

一般描述

本产品按照现行药典要求提供和指定。所有为支持本产品而提供的信息，包括 SDS 和任何产品信息小册子，均由药典颁发机构制定和发布。如需进一步的信息和支持，请访问现行药典网站。如需进一步信息和支持，请访问现行药典网站。

生化/生理作用

氨氯地平是一种 L 型钙通道阻滞剂。氨氯地平属于一类心血管药物，作用于 Ca V 1 或 L 型的电压门控钙通道。氨氯地平还具有降压和抗心绞痛作用。其活性主要存在于 (-)-异构体中。氨氯地平抑制人表皮样癌细胞 A431 的生长，对雄性大鼠有抗生殖作用。

分析说明

这些产品仅供测试和分析使用。它们不适用于人类或动物的给药，不可用于诊断、治疗或治愈任何疾病。

其他说明

USP颁布的SDS请点击此处。
可能适用相应的销售限制。

基本信息

经验(实验)分子式C20H25ClN2O5 · C6H5SO3H
分子量567.05
MDL编号MFCD00887594
PubChem化学物质编号329749008
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringOS(=O)(=O)c1ccccc1.CCOC(=O)C2=C(COCCN)NC(C)=C(C2c3ccccc3Cl)C(=O)OC
InChI1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)
InChI keyZPBWCRDSRKPIDG-UHFFFAOYSA-N
Gene Informationhuman ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779)

安全信息

象形图GHS07
警示用语：Warning
危险声明H302
预防措施声明P264 - P270 - P301 + P312 - P501
危险分类Acute Tox. 4 Oral
储存分类代码11 - Combustible Solids
WGKWGK 3
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