CAS 1105698-15-4; salermide

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CAS:

1105698-15-4

分子式:

C₂₆H₂₂N₂O₂

分子量:

394.47

英文名称:

salermide

n-{3-[(2-hydroxy-naphthalen-1-ylmethylene)-amino]-phenyl}-2-phenyl-propionamide

用途:

Salermide是一种反向酰胺，在体外对Sirt1和Sirt2具有强的抑制作用。相对于Sirt1，Salermide对Sirt2的抑制更为有效。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

S794227

MACKLIN

Salermide

10mM in DMSO

194元/1ml;

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储存：-20°C

S872594

MACKLIN

Salermide

99%

90元/5mg; 197元/25mg; 340元/100mg; 828元/250mg;

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储存：-20℃
状态：黄色粉末

S8825

Sigma-Aldrich

Salermide

≥98% (HPLC)

1642.3元/5 MG; 6650.15元/25 MG;

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产品说明

应用

Salermide was used to treat human pulmonary artery smooth muscle cells to study the effect of SIRT1 inhibition on expression of atrogin by qPCR.¹

包装

5, 25 mg in glass bottle

生化/生理作用

Salermide is a novel Sirtuin 1 (Sirt1) and Sirtuin 2 (Sirt2) inhibitor (III histone deacetylases inhibitor). In vitro Salermide has a stronger inhibitory effect on Sirt2 than on Sirt1. Salermide induces massive apoptosis in tumor cells. The activity was ascribed to effect of Salermide to the reactivation of proapoptotic genes epigenetically repressed exclusively in cancer cells by Sirt1. Salermide is a stronger Sirtuin inhibitor than sirtinol (Cat. No.S7942).

特点和优势

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

基本信息

经验(实验)分子式	C₂₆H₂₂N₂O₂
分子量	394.47
MDL编号	MFCD12912446
PubChem化学物质编号	329824611
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
储存条件	desiccated
颜色	yellow
溶解性	DMSO: >10 mg/mL
储存温度	2-8℃
SMILES string	CC(C(=O)Nc1cccc(c1)\N=C\c2c(O)ccc3ccccc23)c4ccccc4
InChI	1S/C26H22N2O2/c1-18(19-8-3-2-4-9-19)26(30)28-22-12-7-11-21(16-22)27-17-24-23-13-6-5-10-20(23)14-15-25(24)29/h2-18,29H,1H3,(H,28,30)/b27-17+
InChI key	HQSSEGBEYORUBY-WPWMEQJKSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3

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