应用 Isopropyl tetradecanoate is used as a solvent in perfume products and the oil phase in the preparation of formulations. It finds application in eye makeup, nail care products, soaps and detergents, hair care products, shaving products and other skin care products. It behaves as a non-aqueous component of the two-phase mouthwash, Dentyl pH, thereby it removes bacteria from the oral cavity.
备注 Incompatible with strong oxidizing agents.
基本信息
MDL MFCD00008982
EINECS 203-751-4
分子式 CH3(CH2)12CO2CH(CH3)2
分子量 270.46
沸点 191-194°/20mm
闪点 152°(306°F)
密度 0.85
灵敏度 Ambient temperatures.
形态 Liquid
溶解性 Miscible with alcohol. Immiscible with water and glycerol.
GHS危害和防范说明
GHS符号
Hazard Statements H315 Causes skin irritation.
Precautionary Statements P280g-P264-P321-P332+P313-P302+P352a-P362+P364 Wear protective gloves.Wash thoroughly after handling.Specific treatment (see label).If skin irritation occurs: Get medical advice/attention.If skin irritation occurs: Get medical advice/attention.
安全信息
危险类别 38 Irritating to skin.
安全等级 23-26-37-60 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer).In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.This material and its container must be disposed of as hazardous waste
Pharmaceutical Secondary Standard; Certified Reference Material
1359.83元/1 G;
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产品说明
一般描述
Isopropyl myristate is an ester of isopropyl alcohol myristic acid. It is mainly used as a solubilizer, emulsifier and emollient in cosmetic and topical medicines. It also finds applications as a flavoring agent in the food industry. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
应用
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
分析说明
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
其他说明
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
附注
To see an example of a Certificate of Analysis for this material enter LRAA7001 in the slot below. This is an example certificate only and may not be the lot that you receive.
基本信息
线性分子式
CH3(CH2)12COOCH(CH3)2
分子量
270.45
Beilstein
1781127
EC 号
203-751-4
MDL编号
MFCD00008982
PubChem化学物质编号
329823144
NACRES
NA.24
产品性质
质量水平
300
等级
certified reference material pharmaceutical secondary standard
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable gas chromatography (GC): suitable
折射率
n20/D 1.434 (lit.)
bp
193 ℃/20 mmHg (lit.)
mp
~3 ℃ (lit.)
密度
0.85 g/mL at 25 ℃ (lit.)
application(s)
cleaning products cosmetics flavors and fragrances food and beverages personal care pharmaceutical (small molecule)
格式
neat
药典可追溯性
traceable to PhEur I0750000 traceable to USP 1350400
Isopropyl myristate (myristic acid isopropyl ester) is used to change the physicochemical characteristics of microsheres such as poly(lactic-co-glycolic acid) (PLGA) microspheres. Isopropyl myristate is used as a oil phase component in the formulaton of microemulsion systems.
United States Pharmacopeia (USP) Reference Standard
3487.56元/500 MG;
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产品说明
一般描述
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
分析说明
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
其他说明
USP issued SDS can be found here. Sales restrictions may apply.
Assay (GC, area%): ≥ 98.0 % (a/a) Density (d 20 °C/ 4 °C): 0.853 - 0.854 Identity (IR): passes test Due to its specific melting range the product may be solid, liquid, a solidified melt or a supercooled melt.
参考文献： [1]. Engelbrecht, T, et al. (2012). Study of the influence of the penetration enhancer isopropyl myristate on the nanostructure of stratum corneum lipid model membranes using neutron diffraction and deuterium labelling. Skin Pharmacol Physiol, 25:200-7 [2]. Brinkmann I, et al. Role of isopropyl myristate, isopropyl alcohol and a combination of both in hydrocortisone permeation across the human stratum corneum. Skin Pharmacol Appl Skin Physiol. 2003 Nov-Dec;16(6):393-404. [3]. Furuishi T, et al. Synergistic effect of isopropyl myristate and glyceryl monocaprylate on the skin permeation of pentazocine. Biol Pharm Bull. 2010;33(2):294-300.
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