CAS 109-12-6; 2-嘧啶胺; Pyrimidin-2-ylamine

CAS:

109-12-6

分子式:

C4H5N3

分子量:

95.10

沸点:

158℃(139

熔点:

124-127℃

中文名称:

2-嘧啶胺

2-氨基嘧啶

英文名称:

Pyrimidin-2-ylamine

2-amino-pyrimidin

2-aminopyrimidine

2-pyridiylamine

2-pyrimidinamine

1,2-dihydro-2-imine-pyrimidin

2-Aminopyrimidine;2-Amino-1,3-diazine

Pyrimidone-2-imide

2-Pyrimidinemine

性质描述:

该品为无色针状晶体。熔点127-128℃（124-125℃）。易溶于水，较难溶于乙醚、苯。易升华。

生产方法:

以糠氯酸、硝酸胍为原料，经环合、脱羧、脱氯而得。将加入甲醇钠的甲醇溶液及硝酸胍，在40-45℃下于30min内过滤，得游离胍的甲醇溶液。将此溶液加入反应罐中，在95℃30min内加入糠氯酸-甲醇溶液，加毕，于60±1℃保温反应40min，减压蒸馏，蒸出甲醇至一定的数量后停止蒸馏，将反应物加水溶解，在30-35℃以30%盐酸酸化至pH=1，过滤水洗，在95℃干燥，得粗品环合物。将粗品环合物置于升华器内，在150-300℃分段脱羧升华，得2-氨基-5-氯啶[5428-89-7]。环合、脱羧的收率约67.5%。将异丙醇、水苛性钠、锌泥、（氢氧化锌60%）、2-氨基-5-氯嘧啶及锌粉加入反应罐中，在77-80℃回流8h后，先回收低沸点馏出物，在77-100℃回收异丙醇。冷至77-85℃过滤，以热水洗涤滤饼。滤液及部分洗液合并，加入粒状苛性钠，在50℃以下碱析1h。用甲醛酯于70℃以下提取，分出胶状物，用盐酸调节pH=7.5-8，再分出油状物，然后回收甲醛酯，析出2-氨基嘧啶。在40-50℃干燥得成品，收率为85.7%。另一种方法是用盐酸胍和丙炔醛反应。在装有温度计、滴液漏斗、搅拌器的300ml三口烧瓶中，加入90ml浓盐酸，外部用冰盐浴冷却。在搅拌状况下于10℃以下加27g纯度约80%的盐酸胍，待二氧化碳放完后，再冷却到0℃，滴入11.1g粗丙炔醛（折纯品为8.7g），滴加时放热，反应温度随之上升，但掌握不得超过20℃。反应放热停止后，在室温下放置一夜，然后将反应液移入蒸馏瓶中，于35℃左右减压蒸发浓缩，放冷后，加入60ml30%的氢氧化钠溶液，析出生成物2-氨基嘧啶。将此物在60-70℃用1500ml苯提取，苯溶液放冷后用氯化钙干燥。蒸馏除去苯，得产品10.2-10.7g，产率66.5%-70%。熔点125-127℃。

用途:

用于有机合成，作医药中间体、生化试剂。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

A762068

MACKLIN

2-氨基嘧啶

10mM in DMSO

890元/1ml;

展开

储存：-20°C, 避光

A800769

MACKLIN

2-氨基嘧啶

98%

28元/5g; 33元/25g; 115元/100g; 554元/500g;

展开

储存：室温
状态：白色到黄色粉末或晶体

A0412

TCI

2-Aminopyrimidine

>98.0%(GC)(T)

235元/25G;

展开

基本信息

纯度/分析方法	>98.0%(GC)(T)
分子式/分子量	C₄H₅N₃ = 95.11
外观与形状(20℃)	固体
Reaxys-RN	107014
PubChem物质ID	87562046
SDBS (AIST Spectral DB)	3858
MDL编号	MFCD00006089

技术规格

Appearance	White to Light yellow powder to crystal
Purity(GC)	min. 98.0 %
Purity(Nonaqueous Titration)	min. 98.0 %
Melting point	124.0 to 128.0 ℃

物性(参考值)

熔点	125 ℃
水溶性	可溶
溶解性(可溶于)	甲醇

安全信息

图形或危害标志
信号词	警告
危险性说明	H303 : 吞咽可能有害。 H315 : 造成皮肤刺激。 H319 : 造成严重眼刺激。
防范说明	P264 : 作业后彻底清洗皮肤。 P280 : 戴防护手套/戴防护眼罩/戴防护面具。 P302 + P352 : 如皮肤沾染：用水充分清洗。 P312 : 如感觉不适，呼叫急救中心/医生。 P337 + P313 : 如仍觉眼刺激：求医/就诊。 P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。 P332 + P313 : 如发生皮肤刺激：求医/就诊。

相关法规

RTECS#

UV6326000

165649

J&K

2-Aminopyrimidine

99%

81元/25G; 203元/100G; 943元/500G;

展开

基本信息

分子式	C₄H₅N₃
分子量	95.10
熔点	122-126
MDL编码	MFCD00006089
Beilstein	107014
EINECS 编号	203-648-4

安全信息

图形或危害标志
提示语	Warning
危险说明	H315 H319 H335
防范说明	P261 P305+P351+P338
WGK	3
RTECS	UV6326000
TSCA	是

B24594

Alfa Aesar

2-Aminopyrimidine

98%

613元/100g; 2472元/500g;

展开

基本信息

MDL
MFCD00006089

EINECS
203-648-4

分子式
C₄H₅N₃

分子量
95.11

熔点
123-127°

沸点
159°/186mm

形态
Crystalline powder

Beilstein
107014

GHS危害和防范说明

GHS符号

Hazard Statements
H315-H319-H335
Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
36/37/38
Irritating to eyes, respiratory system and skin.

安全等级
26-37-60
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.This material and its container must be disposed of as hazardous waste

RTECS
UV6326000

TSCA
是

C10458

Alfa Aesar

2-Aminopyrimidine

98%

551元/5g; 773元/100g; 3491元/500g;

展开

基本信息

Ref#
10458

MDL
6089

分子式
C4 H5 N3

分子量
95.1

闪点
103

形态
White to pale yellow cryst powder

Y0001469

Sulfadiazine impurity A

European Pharmacopoeia (EP) Reference Standard

1277.32元/ ;

展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 20 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₄H₅N₃
分子量	95.10
Beilstein	107014
MDL编号	MFCD00006089
PubChem化学物质编号	329831439
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	EDQM
mp	122-126 ℃ (lit.)
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	Nc1ncccn1
InChI	1S/C4H5N3/c5-4-6-2-1-3-7-4/h1-3H,(H2,5,6,7)
InChI key	LJXQPZWIHJMPQQ-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

A78608

Sigma-Aldrich

2-Aminopyrimidine

97%

622.56元/100 G; 3016元/500 G;

展开

基本信息

经验(实验)分子式	C₄H₅N₃
分子量	95.10
Beilstein	107014
EC 号	203-648-4
MDL编号	MFCD00006089
PubChem化学物质编号	24891286
NACRES	NA.22

产品性质

质量水平	100
测定	97%
mp	122-126 ℃ (lit.)
SMILES string	Nc1ncccn1
InChI	1S/C4H5N3/c5-4-6-2-1-3-7-4/h1-3H,(H2,5,6,7)
InChI key	LJXQPZWIHJMPQQ-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

036344

Fluorochem

2-Aminopyrimidine

97%

220元/1g; 242元/25g; 550元/100g; 880元/250g;

展开

基本信息

CAS Number	109-12-6
MDL Number	MFCD00006089

安全信息

图形或危害标志
危险性说明	H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .