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CAS: 109-04-6
分子式: C5H4BrN
分子量: 158.00
沸点: 192-194℃
熔点: 193 °C
中文名称: 
α-溴氮杂苯
α-溴吡啶
2-溴吡啶
英文名称: 
-Bromopyridine
-Bromoazine
Pyridine,2-bromo-
2-bromo-pyridine
2-Bromopyridine
2-bromo-Pyridine
2-pyridyl bromide
beta-bromopyridine
o-bromopyridine
2-bromo-pyridin
性质描述: 浅黄色油状液体。沸点193-194℃,74-75℃(1.73kPa),相对密度1.657(15/4℃),折光率1.5734。能与乙醇、乙醚、苯和吡啶相混溶,尚溶于水。
生产方法: 由2-氨基吡啶经溴化而得。工业生产中是先将氢溴酸(48%以上)冷至0℃以下,慢慢加入2-氨基吡啶,然后在盐浴冷冻下滴加液溴,加入速度以控制反应温度在-5℃以下为宜。加完后滴加亚硝酸钠水溶液,控制反应温度在0℃以下,搅拌20-30min,滴加50%氢氧化钠溶液,反应液用乙醚提取、水洗,以无水硫酸钠干燥、过滤,回收乙醚,残留物经减压蒸馏,收集88℃-94℃/3333Pa馏份,即得成品,收率83.8%。
用途: 有机合成,医药中间体。在医药工业中用于合成心脏病类药双异丙吡胺(磷酸丙吡胺)等。
推荐供应商
货号品牌产品名称规格包装、参考价格
B802661MACKLIN2-溴吡啶98%32元/25g;   95元/100g;   386元/500g;   1925元/2.5kg;   咨询
储存:2~8°C
状态:无色到浅黄色液体
折射率:n20/D 1.572(lit.)
B742914MACKLIN2-溴吡啶Standard for GC, ≥99.9%(GC)128元/5g;   咨询
储存:2-8°C
状态:液体
B0650TCI2-Bromopyridine>98.0%(GC)200元/25ML;   555元/100ML;   2135元/500ML;   咨询

基本信息

纯度/分析方法>98.0%(GC)
分子式/分子量C5H4BrN = 158.00
外观与形状(20℃)液体
应避免的情况光
Reaxys-RN105789
PubChem物质ID87563657
SDBS (AIST Spectral DB)4236
MDL编号MFCD00006219

技术规格

AppearanceColorless to Light yellow clear liquid
Purity(GC)min. 98.0 %

物性(参考值)

沸点194 ℃
闪点54 ℃
比重1.63
折射率1.57
水溶性可溶

安全信息

图形或危害标志
信号词危险
危险性说明H310 : 皮肤接触致命。
H301 : 吞咽会中毒。
H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
H226 : 易燃液体和蒸气。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P262 : 严防进入眼中、接触皮肤或衣服。
P240 : 容器和装载设备接地/等势联接。
P210 : 远离热源/火花/明火/热表面。禁止吸烟。
P233 : 保持容器密闭。
P243 : 采取防止静电放电的措施。
P241 : 使用防爆的电气/通风/照明设备。
P242 : 只能使用不产生火花的工具。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P370 + P378 : 火灾时:使用干砂、干粉或抗醇泡沫灭火。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P361 + P364 : 立即脱掉所有沾染的衣服,清洗后方可重新使用。
P303 + P361 + P353 : 如皮肤(或头发)沾染:立即脱掉所有沾污的衣物。用水清洗皮肤/淋浴。
P332 + P313 : 如发生皮肤刺激:求医/就诊。
P301 + P310 + P330 : 如误吞咽:立即呼叫急救中心/医生。漱口。
P403 + P235 : 存放在通风良好的地方。保持低温。
P405 : 存放处须加锁。

相关法规

RTECS#US3850000

运输信息

UN编号UN2929
类别6.1 / 3
包装类别 II
监管条件代码(*)
145051J&K2-Bromopyridine99%101元/25G;   284元/100G;   992元/500G;   咨询

基本信息

分子式C5H4BrN
分子量158.00
沸点192-194
闪点54
密度1.657
折光率(n20D)1.5720
MDL编码MFCD00006219
Beilstein105789
EINECS 编号203-641-6
存储条件Store at 2-8℃

安全信息

图形或危害标志
提示语Danger
危险说明H301
H310
H315
H319
H335
防范说明P261
P280
P301+P310
P302+P350
P305+P351+P338
P310
UN号码2929
危险分类6.1
次要危险性3
包装等级II
WGK3
RTECSUS3850000
TSCA是
A13241Alfa Aesar2-Bromopyridine99%300元/25g;   889元/100g;   1978元/250g;   3309元/500g;   咨询

应用
2-Bromopyridine is used in the preparation of a variety of biologically active compounds like antimalarial agents. It is also used to prepare beta-adrenoceptor agonist.

备注
Keep away from heat, sparks, and flame. Hygroscopic. Incompatible with strong oxidizing agents, strong acids and acid chlorides.

基本信息

MDL
MFCD00006219

EINECS
203-641-6

分子式
C5H4BrN

分子量
158.00

沸点
192-194°

闪点
97°(207°F)

密度
1.625

折射率
1.5720

灵敏度
Ambient temperatures.

形态
Liquid

溶解性
Slightly miscible with water.

Beilstein
105789

GHS危害和防范说明

GHS符号

Hazard Statements
H301-H310-H315-H319-H335
Toxic if swallowed.Fatal in contact with skin.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P280h-P305+P351+P338-P309-P310
Wear protective gloves/clothing.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF exposed or if you feel unwell:Immediately call a POISON CENTER or doctor/physician.

安全信息

危险等级
6.1

包装组
II

危险类别
24/25-36/37/38
Toxic in contact with skin and if swallowed.Irritating to eyes, respiratory system and skin.

安全等级
20-23-26-27-36/37/39-45-60
When using do not eat or drink.Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer).In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Take off immediately all contaminated clothing.Wear suitable protective clothing, gloves and eye/face protection.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).This material and its container must be disposed of as hazardous waste

RTECS
US3850000

TSCA
是

C10740Alfa Aesar2-Bromopyridine99%967元/25ml;   2987元/100ml;   16146元/500ml;   咨询

基本信息

Ref#
10740

MDL
6219

分子式
C5 H4 Br N

分子量
158

闪点
54

密度
1.65

形态
Colorless to pale yellow liquid

安全信息

危险等级
6.1

包装组
II

B80100Sigma-Aldrich2-Bromopyridine99%380.47元/25 G;   850.13元/100 G;   3753.92元/500 G;   咨询

产品说明

应用

2-溴吡啶可用作:

  • 通过各种交叉偶联反应形成C−N键的合成砌块。
  • 通过钯催化与卤代芳烃进行Negishi交叉偶联反应的反应剂。
  • 在存在铜的条件下,用作催化合成2′-吡啶二氟乙酸乙酯的反应剂。

包装

25, 100, 500 g in glass bottle

基本信息

经验(实验)分子式C5H4BrN
分子量158.00
Beilstein105789
EC 号203-641-6
MDL编号MFCD00006219
PubChem化学物质编号24892038
NACRESNA.22

产品性质

质量水平200
测定99%
形式liquid
折射率n20/D 1.572 (lit.)
bp192-194 ℃ (lit.)
密度1.657 g/mL at 25 ℃ (lit.)
SMILES stringBrc1ccccn1
InChI1S/C5H4BrN/c6-5-3-1-2-4-7-5/h1-4H
InChI keyIMRWILPUOVGIMU-UHFFFAOYSA-N

安全信息

象形图GHS06
警示用语:Danger
危险声明H301 - H310 - H315 - H319 - H335
预防措施声明P262 - P280 - P301 + P310 + P330 - P302 + P352 + P310 - P305 + P351 + P338
危险分类Acute Tox. 2 Dermal - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3
个人防护装备Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
577609Amethyst2-Bromopyridine99%, 用于合成65元/25G;   156元/100G;   572元/500G;   咨询

基本信息

分子式C5H4BrN
分子量158.00
沸点192-194
闪点54
密度1.657
折光率(n20D)1.5720
MDL编码MFCD00006219
Beilstein105789
EINECS 编号203-641-6
存储条件Store at 2-8℃

安全信息

图形或危害标志
提示语Danger
危险说明H301
H310
H315
H319
H335
防范说明P261
P280
P301+P310
P302+P350
P305+P351+P338
P310
UN号码2929
危险分类6.1
次要危险性3
包装等级II
WGK3
RTECSUS3850000
TSCA是
036222Fluorochem2-Bromopyridine98%198元/5g;   220元/10g;   242元/25g;   550元/100g;   1650元/500g;   咨询

基本信息

CAS Number109-04-6
MDL NumberMFCD00006219
Boiling Point192-194℃
Density1.65

安全信息

图形或危害标志
危险性说明 H226: Flammable liquid and vapour.
H301: Toxic if swallowed.
H310: Fatal in contact with skin.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P210: Keep away from – No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof ./ equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P260: Do not breathe .
P261: Avoid breathing
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302 + P350: IF ON SKIN: Gently wash with plenty of soap and water.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P303 + P361 + P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P310: Immediately call a POISON CENTER or doctor/physician.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P322: Specific measures (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P361: Remove/Take off immediately all contaminated clothing.
P362: Take off contaminated clothing and wash before reuse.
P363: Wash contaminated clothing before reuse.
P370 + P378: In case of fire: Use CO2, dry powder or foam for extinction.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P403 + P235: Store in a well-ventilated place. Keep cool.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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