CAS 107-97-1; 肉桂基酸; Sarcosine

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767908

MACKLIN

肌氨酸

10mM in Water

185元/1ml;

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储存：-20°C

S817487

MACKLIN

肌氨酸

99%

45元/25g; 148元/100g; 575元/500g; 2389元/2.5kg;

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储存：室温,干燥
状态：白色到黄色粉末或晶体

S6019

MACKLIN

肌氨酸

99%生物技术级

39元/10g; 140元/50g; 598元/250g; 2230元/1kg;

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储存：室温,干燥
状态：白色到黄色粉末或晶体

M0332

TCI

Sarcosine

>98.0%(T)

185元/25G; 385元/100G; 1090元/500G;

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基本信息

纯度/分析方法	>98.0%(T)
分子式/分子量	C₃H₇NO₂ = 89.09
外观与形状(20℃)	固体
储存在惰性气体下	存放于惰性气体之中
应避免的情况	湿气 (吸湿)
Reaxys-RN	1699442
PubChem物质ID	87572403
SDBS (AIST Spectral DB)	3588
Merck Index (14)	8373
MDL编号	MFCD00004279

技术规格

Appearance	White to Almost white powder to crystaline
Purity(Nonaqueous Titration)	min. 98.0 %
Solubility in Water	almost transparency

物性(参考值)

熔点	210 ℃
水溶性	可溶
溶解性(微溶于)	醇

相关法规

RTECS#

VQ2897000

237425

J&K

Sarcosine

99%, 是1型甘氨酸转运蛋白 (GlyT) 抑制剂和甘氨酸结合位点的N-甲基-D-天冬氨酸 (NMDA) 受体共激动剂

72元/25G; 235元/100G; 761元/500g;

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基本信息

分子式	C₃H₇NO₂
分子量	89.09
熔点	208-212
闪点	>100
MDL编码	MFCD00004279
Beilstein	1699442
Merck	14,8373
EINECS 编号	203-538-6

产品描述

Sarcosine是GlyT1的竞争性抑制剂以及天冬氨酸受体（NMDAR）的协同激动剂。

靶点（IC50 & Targe）

GlyT1

NMDA receptor

体外研究

Sarcosine除了是GlyT1的抑制剂和NMDAR的协同激动剂外，它还是GlyR的激动剂，但是相比甘氨酸来说，sarcosine的效力比较弱，所以不是一个完全激动剂[1]。Sarcosine处理过的细胞的细胞活力显著下降[4]。

体内研究

Sarcosine的抗痉挛效果比较弱[2]。它在mGluR5敲除小鼠中可改善其前脉冲抑制缺陷障碍[3]。

细胞实验

Cell lines: PC-3 前列腺癌细胞株

Concentrations: 10, 150, 250, 500, 1,000 和 1,500 μM

Incubation Time: 0, 6, 12, 24 和 72 h

Method: 细胞生长至50%-60%融合时，将培养基更换为新鲜培养室，使细胞生长同步。培养24小时，然后用含终浓度为10, 150, 250, 500, 1,000 和 1,500 μM 的sarcosine的培养基处理细胞。处理0, 6, 12, 24 和 72 小时，在每个时间点收集细胞。

(Only for Reference)

动物实验

Cell lines: PC-3 前列腺癌细胞株

Concentrations: 10, 150, 250, 500, 1,000 和 1,500 μM

Incubation Time: 0, 6, 12, 24 和 72 h

(Only for Reference)

参考文献

[1] Zhang HX, et al. Neuropharmacology. 57(5-6):551-5.

[2] Socała K, et al. Pharmacol Rep. 2010, 62(2):392-7.

[3] Chen HH, et al. Psychopharmacology (Berl). 2010, 209(4):343

安全信息

防范说明	P262
WGK	1
RTECS	VQ2897000
TSCA	是

A14594

Alfa Aesar

Sarcosine

98%

868元/100g; 2814元/500g; 12015元/2500g;

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应用
A type 1 glycine transporter inhibitorSarcosine is used in the production of biodegradable surfactants and toothpastes. It is used as an intermediate in the synthesis of antienzyme agents. It is found to be a marker for prostate cancer bioagression. It acts as a biochemical reagent, dye stabilizer, daily chemical, amino acid surfactants, health drugs fatigue recovery agent and so on. It is involved in the preparation of N-methyl-glycine ethyl ester by reacting with ethanol.

备注
Incompatible with strong oxidizing agents.

基本信息

MDL
MFCD00004279

EINECS
203-538-6

分子式
CH₃NHCH₂CO₂H

分子量
89.09

熔点
ca 208° dec.

灵敏度
Hygroscopic. Store under Argon. Ambient temperatures.

形态
Crystalline powder

溶解性
Soluble in water, methanol. Slightly soluble in ether.

Beilstein
1699442

Merck
14,8373

安全信息

RTECS
VQ2897000

TSCA
是

C15774

Alfa Aesar

Sarcosine

98%

737元/100g; 2118元/500g; 9838元/2.5kg;

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基本信息

Ref#
15774

MDL
4279

分子式
C3 H7 N O2

分子量
89.09

闪点
>100

形态
White crystalline powder

84532

Sigma-Aldrich

Sarcosine

crystallized, ≥98.0% (T)

1318.94元/250 G; 2622.73元/1 KG;

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基本信息

线性分子式	CH₃NHCH₂COOH
分子量	89.09
Beilstein	1699442
EC 号	203-538-6
MDL编号	MFCD00004279
PubChem化学物质编号	329769303

产品性质

质量水平	200
测定	≥98.0% (T)
形式	powder with small lumps
质量	crystallized
颜色	white
mp	208-212 ℃ (dec.) (lit.) 208-212 ℃ (dec.)
application(s)	cell analysis peptide synthesis
SMILES string	CNCC(O)=O
InChI	1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6)
InChI key	FSYKKLYZXJSNPZ-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

131776

Sigma-Aldrich

Sarcosine

98%

628.56元/100 G; 1995.76元/500 G;

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基本信息

线性分子式	CH₃NHCH₂COOH
分子量	89.09
Beilstein	1699442
EC 号	203-538-6
MDL编号	MFCD00004279
PubChem化学物质编号	24848035
NACRES	NA.26

产品性质

质量水平	200
测定	98%
形式	powder or crystals
technique(s)	cell culture \| mammalian: suitable
颜色	white
mp	208-212 ℃ (dec.) (lit.)
application(s)	peptide synthesis
SMILES string	CNCC(O)=O
InChI	1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6)
InChI key	FSYKKLYZXJSNPZ-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

8.07666

Sigma-Aldrich

Sarcosine

for synthesis

814.98元/250 G;

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基本信息

经验(实验)分子式	C₃H₇NO₂
分子量	89.09
MDL编号	MFCD00004279
EC索引号	203-538-6

产品性质

质量水平	200
pH值(酸碱度)	6.1 (20 ℃, 100 g/L in H₂O)
溶解性	1481 g/L
堆积密度	600 kg/m³
储存温度	2-30℃
InChI	1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6)
InChI key	FSYKKLYZXJSNPZ-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable

S7672

Sigma-Aldrich

Sarcosine

BioXtra

280.59元/10 MG; 1814.58元/25 G; 3171.7元/100 G;

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基本信息

线性分子式	CH₃NHCH₂COOH
分子量	89.09
Beilstein	1699442
EC 号	203-538-6
MDL编号	MFCD00004279
PubChem化学物质编号	24899761
NACRES	NA.26

产品性质

质量水平	200
产品线	BioXtra
测定	≥98%
形式	powder
technique(s)	HPLC: suitable
杂质	≤0.0005% Phosphorus (P) ≤0.1% Insoluble matter
灼烧残渣	≤0.1%
颜色	white
mp	208-212 ℃ (dec.) (lit.)
溶解性	H₂O: 1 M, clear, colorless
痕量阴离子	chloride (Cl^-): ≤0.5% sulfate (SO₄^2-): ≤0.05%
痕量阳离子	Al: ≤0.0005% Ca: ≤0.0005% Cu: ≤0.0005% Fe: ≤0.001% K: ≤0.005% Mg: ≤0.0005% NH₄⁺: ≤0.1% Na: ≤0.05% Pb: ≤0.001% Zn: ≤0.0005%
application(s)	cell analysis
SMILES string	CNCC(O)=O
InChI	1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6)
InChI key	FSYKKLYZXJSNPZ-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

095119

Fluorochem

Sarcosine

99%

220元/25g; 264元/100g; 792元/500g;

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基本信息

CAS Number	107-97-1
MDL Number	MFCD00004279
Boiling Point	165.17℃
Melting Point	202-215℃
Density	1.1948

安全信息

图形或危害标志
危险性说明	H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .