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CAS: 106266-06-2
分子式: C23H27FN4O2
分子量: 410.49
熔点: 172°C
中文名称: 
利培酮
英文名称: 
4h-pyrido(1,2-a)pyrimidin-4-one, 6,7,8,9-tetrahydro-3-(2-(4-(6-fluoro-1,2-benzi
soxazol-3-yl)- 1-piperidinyl)ethyl)-2-methyl-
r 64766
risperidone
推荐供应商
货号品牌产品名称规格包装、参考价格
R793308MACKLIN利培酮in 2mM DMSO520元/1ml;   咨询
储存：-20°C
R830745MACKLIN利培酮99%58元/1g;   218元/5g;   940元/25g;   3740元/100g;   咨询
储存：室温,密封
状态：白色到淡黄色固体
R0087TCIRisperidone>98.0%(T)(HPLC)1080元/50MG;   3795元/500MG;   咨询

基本信息

纯度/分析方法>98.0%(T)(HPLC)
分子式/分子量C23H27FN4O2 = 410.49
外观与形状(20℃)固体
Reaxys-RN4891881
PubChem物质ID125307687
Merck Index (14)8233
MDL编号MFCD00274576

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(HPLC)min. 98.0 area%
Purity(Nonaqueous Titration)min. 98.0 %
Melting point170.0 to 174.0 ℃

物性(参考值)

熔点172 ℃

安全信息

图形或危害标志
信号词危险
危险性说明H301 : 吞咽会中毒。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P301 + P310 + P330 : 如误吞咽：立即呼叫急救中心/医生。漱口。
P405 : 存放处须加锁。

相关法规

RTECS#UV1164800

运输信息

UN编号UN2811
类别6.1
包装类别 III
监管条件代码(*)
140636J&KRisperidone99.5%, 多巴胺、5 -羟色胺、肾上腺素、组胺等受体拮抗剂641元/50MG;   1472元/250mg;   2796元/5G;   咨询

基本信息

分子式C23H27FN4O2
分子量410.48
熔点170-174
MDL编码MFCD00274576
Beilstein4891881
Merck14,8233
存储条件Freezer -20℃

产品描述

Risperidone 是一种多靶点的拮抗剂，作用于dopamine, serotonin, adrenergic and histamine receptors，用于治疗精神分裂症以及抑郁狂躁型忧郁症。

靶点（IC50 & Targe）

5-HT2A,0.17nM(Ki)

D2,3.57nM(Ki)

D2L,4.16nM(Ki)

D3,3.6nM(Ki)

α2C-adrenergic receptor,1.3nM(Ki)

体外研究

Risperidone结合DA和血清素（5HT）受体，特别是在纹状体和边缘结构的神经元中。Risperidone显著影响脑的神经生长因子（NGF）水平，表明它影响的内源生长因子的转化率。Risperidone显著降低额叶，枕叶皮层和海马中BDNF浓度，减少或增加在选定的大脑结构中的TrkB受体。[1]在大鼠前脑区域中，Risperidone显著增加D（2）在内侧前额叶皮质结合达34％。在大鼠前脑区域中，Risperidone上调额叶，枕叶皮层和海马中D（2）受体分别达37％，32％和37％。[2] 在活化的小胶质细胞中，Risperidone显著抑制NO和促炎细胞因子的产生。[3]在Caco-2细胞中，Risperidone (1-50 mM)通过抑制P-gp的活性显著增强Rh123的细胞内积累，IC（50）值为5.87 mM。[4]

体内研究

Risperidone不显著影响体重增益（BWG），食物摄取（FI），葡萄糖耐受性或瘦蛋白水平，虽然催乳素和皮质酮在雄性大鼠中显著升高。Risperidone显著增加雌性大鼠的BWG和FI。[5] 在白色脂肪组织（WAT）中，Risperidone（0.05 毫克/千克）增加食物摄取和瘦素基因表达，但体重增益率在大鼠中不受影响。Risperidone（0.5 毫克/千克）导致体重增益的减少，以及BAT中增强的UCP1基因表达，大鼠中血清催乳素浓度的增加。[6]

参考文献

[1] Angelucci F, et al. J Neurosci Res,?000, 60(6), 783-794.

[2] Tarazi FI, et al. J Pharmacol Exp Ther,?001, 297(2), 711-717.

[3] Kato T, et al. Schizophr Res,?007, 92(1-3), 108-115.

[4] Zhu HJ, et al. Neuropsychopharmacology,?007, 32(4), 757-764.

[5] Baptista T, et al. Brain Res,?002, 957(1), 144-151.

安全信息

图形或危害标志
提示语Danger
危险说明H301
防范说明P301+P310
UN号码2811
危险分类6.1
包装等级III
WGK3
RTECSUV1164800
PHR1631SupelcoRisperidonePharmaceutical Secondary Standard; Certified Reference Material2877.68元/500 MG;   咨询

产品说明

一般描述

用于质量控制的制药二级标准品，为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案
利培酮是一种新的中枢 5-羟色胺 2 和多巴胺 D2 拮抗剂。它用于治疗痴呆期引起的激越、攻击行为和精神病。它是精神抑制药。它也是一种非典型抗精神病药物，用于治疗精神分裂症。
利培酮是一种精神药物，属于苯并异恶唑衍生物类化合物，通常用于治疗精神分裂症。

应用

利培酮可用作药物参考标准品，用于通过比色技术和反相高效液相色谱技术对药物制剂中的分析物进行定量。
这些二级标准品是合格的认证标准物质(CRM)。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。

分析说明

这些二级标准品可追溯至USP、EP和BP一级标准品(在它们可用的情况下)。

其他说明

本有证参考物质 (CRM) 按照 ISO 17034 和 ISO/IEC 17025 生产和认证。有关本 CRM 使用的所有信息，请参见分析证书。

附注

欲查看此物质的分析证书样本，请在下面的对话框中输入LRAC2895。这只是一个示例证书，可能与您收到的批次不符。

基本信息

经验(实验)分子式C23H27FN4O2
分子量410.48
MDL编号MFCD00274576
PubChem化学物质编号329823521
NACRESNA.24

产品性质

质量水平300
等级certified reference material
pharmaceutical secondary standard
CofAcurrent certificate can be downloaded
包装pkg of 500 mg
technique(s)HPLC: suitable
gas chromatography (GC): suitable
application(s)pharmaceutical (small molecule)
格式neat
药典可追溯性traceable to BP 1137
traceable to PhEur R1000600
traceable to USP 1604654
储存温度2-30℃
SMILES stringCC1=C(CCN2CCC(CC2)c3noc4cc(F)ccc34)C(=O)N5CCCCC5=N1
InChI1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3
InChI keyRAPZEAPATHNIPO-UHFFFAOYSA-N
Gene Informationhuman ... DRD2(1813), HTR2A(3356), HTR2C(3358)

安全信息

象形图GHS06
警示用语：Danger
危险声明H301
预防措施声明P301 + P310
危险分类Acute Tox. 3 Oral
储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
R1000600RisperidoneEuropean Pharmacopoeia (EP) Reference Standard1572.27元/ ;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Risperidone is a new central 5-hydroxytryptamine2 and dopamine D2 antagonist. It is used to treat agitation, aggression,and psychosis caused during demnetia. It is a neuroleptic drug. It is also an atypical antipsychotic drug which is used for treating schizophrenia.

包装

Unit quantity: 50 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C23H27FN4O2
分子量410.48
MDL编号MFCD00274576
PubChem化学物质编号329823994
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringCC1=C(CCN2CCC(CC2)c3noc4cc(F)ccc34)C(=O)N5CCCCC5=N1
InChI1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3
InChI keyRAPZEAPATHNIPO-UHFFFAOYSA-N
Gene Informationhuman ... DRD2(1813), HTR2A(3356), HTR2C(3358)

安全信息

象形图GHS06
警示用语：Danger
危险声明H301
预防措施声明P264 - P270 - P301 + P310 + P330 - P405 - P501
危险分类Acute Tox. 3 Oral
储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
Y0000370Risperidone for system suitabilityEuropean Pharmacopoeia (EP) Reference Standard1277.32元/ ;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Risperidone is a new central 5-hydroxytryptamine2 and dopamine D2 antagonist. It is used to treat agitation, aggression,and psychosis caused during demnetia. It is a neuroleptic drug. It is also an atypical antipsychotic drug which is used for treating schizophrenia.

包装

Unit quantity: 20 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C23H27FN4O2
分子量410.48
MDL编号MFCD00274576
PubChem化学物质编号329830925
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringCC1=C(CCN2CCC(CC2)c3noc4cc(F)ccc34)C(=O)N5CCCCC5=N1
InChI1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3
InChI keyRAPZEAPATHNIPO-UHFFFAOYSA-N
Gene Informationhuman ... DRD2(1813), HTR2A(3356), HTR2C(3358)

安全信息

象形图GHS06
警示用语：Danger
危险声明H301
预防措施声明P301 + P330 + P331 + P310
危险分类Acute Tox. 3 Oral
储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
R3030Sigma-AldrichRisperidone≥98% (HPLC), powder1746.67元/10 MG;   6233.79元/50 MG;   咨询

产品说明

一般描述

利培酮是苯并异恶唑衍生物。它是多巴胺 D2、组胺 H1 和 α1 和 α2 肾上腺素能受体的拮抗剂。利培酮用于治疗精神分裂症、双相情感障碍和自闭症。

应用

利培酮可用于：

  • 研究其对骨形成和分化的影响
  • 研究利多酮(RIS)剂量与自闭症谱系障碍(ASD)儿童患者的血浆利多酮水平之间的关系
  • 逆转诱导小鼠精神分裂症样行为

包装

10, 50 mg in glass bottle

生化/生理作用

利培酮是一种抗精神病药；血清素-多巴胺拮抗剂。

特点和优势

该化合物由 Johnson & Johnson 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单，请单击此处。

基本信息

经验(实验)分子式C23H27FN4O2
分子量410.48
MDL编号MFCD00274576
PubChem化学物质编号329824020
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to off-white
溶解性DMSO: ≥5 mg/mL
创始人Johnson & Johnson
储存温度room temp
SMILES stringCC1=C(CCN2CCC(CC2)c3noc4cc(F)ccc34)C(=O)N5CCCCC5=N1
InChI1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3
InChI keyRAPZEAPATHNIPO-UHFFFAOYSA-N
Gene Informationhuman ... DRD2(1813), HTR2A(3356), HTR2C(3358)

安全信息

象形图GHS06
警示用语：Danger
危险声明H301
预防措施声明P301 + P310
危险分类Acute Tox. 3 Oral
储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
BP1137RisperidoneBritish Pharmacopoeia (BP) Reference Standard1952.55元/100 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C23H27FN4O2
分子量410.48
MDL编号MFCD00274576
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameBP
格式neat
储存温度2-8℃
SMILES stringCC1=C(CCN2CCC(CC2)c3noc4cc(F)ccc34)C(=O)N5CCCCC5=N1
InChI1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3
InChI keyRAPZEAPATHNIPO-UHFFFAOYSA-N
Gene Informationhuman ... DRD2(1813), HTR2A(3356), HTR2C(3358)

安全信息

象形图GHS06
警示用语：Danger
危险声明H301
预防措施声明P301 + P330 + P331 + P310
危险分类Acute Tox. 3 Oral
储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
1604654USPRisperidoneUnited States Pharmacopeia (USP) Reference Standard3231.47元/100 MG;   咨询

产品说明

一般描述

Risperidone is a new central 5-hydroxytryptamine2 and dopamine D2 antagonist. It is used to treat agitation, aggression,and psychosis caused during demnetia. It is a neuroleptic drug. It is also an atypical antipsychotic drug which is used for treating schizophrenia.

应用

It was used as reference standard during RP-UPLC analysis for determination of risperidone related compounds in Risperdal® Consta (risperidone long-acting injection).

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

法律信息

Risperdal is a registered trademark of Johnson & Johnson

基本信息

经验(实验)分子式C23H27FN4O2
分子量410.48
MDL编号MFCD00274576
PubChem化学物质编号329751052
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringCC1=C(CCN2CCC(CC2)c3noc4cc(F)ccc34)C(=O)N5CCCCC5=N1
InChI1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3
InChI keyRAPZEAPATHNIPO-UHFFFAOYSA-N
Gene Informationhuman ... DRD2(1813), HTR2A(3356), HTR2C(3358)

安全信息

象形图GHS06
警示用语：Danger
危险声明H301
预防措施声明P301 + P330 + P331 + P310
危险分类Acute Tox. 3 Oral
储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
BP1158Risperidone impurity standardBritish Pharmacopoeia (BP) Reference Standard1989元/25 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 25 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C23H27FN4O2
分子量410.48
MDL编号MFCD00274576

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameBP
格式mixture
储存温度2-8℃
SMILES stringCC1=C(CCN2CCC(CC2)c3noc4cc(F)ccc34)C(=O)N5CCCCC5=N1
InChI1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3
InChI keyRAPZEAPATHNIPO-UHFFFAOYSA-N
Gene Informationhuman ... DRD2(1813), HTR2A(3356), HTR2C(3358)

安全信息

象形图GHS06
警示用语：Danger
危险声明H301
预防措施声明P264 - P270 - P301 + P310 + P330 - P405 - P501
危险分类Acute Tox. 3 Oral
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
036563Fluorochem3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one97%660元/250mg;   1320元/1g;   3718元/5g;   15598元/25g;   咨询

基本信息

CAS Number106266-06-2
MDL NumberMFCD00274576

安全信息

图形或危害标志
危险性说明 H301: Toxic if swallowed.
H311: Toxic in contact with skin.
H331: Toxic if inhaled.
防范说明 P260: Do not breathe .
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P311: Call a POISON CENTER or doctor/physician.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P322: Specific measures (see . on this label).
P330: Rinse mouth.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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