CAS 1052147-86-0; n-[(4-cyanophenyl)methyl]-4-[1,1′-biphenyl]-2-yl-1-piperazinehexanamide; lp-211

CAS:

1052147-86-0

分子式:

C₃₀H₃₄N₄O

分子量:

466.62

中文名称:

n-[(4-cyanophenyl)methyl]-4-[1,1′-biphenyl]-2-yl-1-piperazinehexanamide

英文名称:

lp-211

n-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide

6-(4-biphenyl-2-yl-piperazin-1-yl)-hexanoic acid 4-cyano-benzylamide

用途:

LP-211 是一种选择性的，可透过血脑屏障的 5-HT7 受体激动剂，Ki 值为 0.58 nM，选择性高于 5-HT1A 受体 (Ki，188 nM) 和 D2 受体 (Ki，142 nM)。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

L884744

MACKLIN

LP-211

≥99%

809元/5mg; 1431元/10mg;

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储存：2-8℃

SML1561

Sigma-Aldrich

LP-211

≥98% (HPLC)

1399.43元/5 MG; 5643.95元/25 MG;

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产品说明

生化/生理作用

LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor with a Ki value of 0.58 nM at rat cloned 5-HT7 receptors, and >300-fold selectivity over the 5-HT1A receptor. The 5-HT7 receptor is involved in a variety of central nervous system functions including circadian rhythm, sleep, thermoregulation, nociception, and memory, and appears to be involved in cognitive disorders, anxiety, and depression. LP-211 has been used as a selective 5-HT7 receptor agonist in multiple models including studies as a potential therapeutic agent in models of Rett syndrome and Fragile X Syndrome.

基本信息

经验(实验)分子式	C₃₀H₃₄N₄O
分子量	466.62
MDL编号	MFCD22690843
PubChem化学物质编号	329825965
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	film
颜色	colorless
溶解性	DMSO: 5 mg/mL, clear (warmed)
储存温度	2-8℃
SMILES string	O=C(NCC1=CC=C(C#N)C=C1)CCCCCN2CCN(C3=CC=CC=C3C4=CC=CC=C4)CC2
InChI	1S/C30H34N4O/c31-23-25-14-16-26(17-15-25)24-32-30(35)13-5-2-8-18-33-19-21-34(22-20-33)29-12-7-6-11-28(29)27-9-3-1-4-10-27/h1,3-4,6-7,9-12,14-17H,2,5,8,13,18-22,24H2,(H,32,35)
InChI key	BQEDZLDNNBDKDS-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable