CAS 103577-45-3; 兰索拉唑; Zoton

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货号

品牌

产品名称

规格

包装、参考价格

L797762

MACKLIN

兰索拉唑

10mM in DMSO

449元/1ml;

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储存：-20°C

L0233

TCI

Lansoprazole

>98.0%(T)(HPLC)

760元/1G; 2035元/5G;

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基本信息

纯度/分析方法	>98.0%(T)(HPLC)
分子式/分子量	C₁₆H₁₄F₃N₃O₂S = 369.36
外观与形状(20℃)	固体
储存温度	0-10℃
应避免的情况	加热
Reaxys-RN	4333393
PubChem物质ID	125307775
Merck Index (14)	5362
MDL编号	MFCD00866873

技术规格

Appearance	White to Light yellow powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(Nonaqueous Titration)	min. 98.0 %

物性(参考值)

熔点	170 ℃(dec.)

安全信息

图形或危害标志
信号词	警告
危险性说明	H315 : 造成皮肤刺激。 H319 : 造成严重眼刺激。
防范说明	P264 : 作业后彻底清洗皮肤。 P280 : 戴防护手套/戴防护眼罩/戴防护面具。 P302 + P352 : 如皮肤沾染：用水充分清洗。 P337 + P313 : 如仍觉眼刺激：求医/就诊。 P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。 P332 + P313 : 如发生皮肤刺激：求医/就诊。

相关法规

RTECS#

DD9487500

952517

J&K

Lansoprazole

98%, 一种质子泵抑制剂(PPI)

862元/1G;

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基本信息

分子式	C₁₆H₁₄F₃N₃O₂S
分子量	369.36
MDL编码	MFCD00866873
存储条件	Store at 2-8℃

产品描述

Lansoprazole是一种质子泵抑制剂（PPI），防止胃产生胃酸。

靶点（IC50 & Targe）

Proton pump [1]

体外研究

Lansoprazole通过抑制胃氢/钾的腺苷三磷酸酶抑制胃酸分泌（H +，K + - ATP酶），胃壁细胞膜的酶形成所述质子泵，是酸分泌过程中的最后步骤的一部分的酶。Lansoprazole共价结合于壁细胞的H +，K + - ATP酶，使其无功能和抑制胃酸的分泌。[1] Lansoprazole是一种很强的抗分泌剂，作用于胃H +/ K+ - 腺苷胃壁细胞三磷酸的（H+/ K+ ATP酶）。Lansoprazole抑制血管粘附分子的表达增加，中性粒细胞的活化，以及生产促炎细胞因子从激活的内皮细胞的产生。Lansoprazole诱导的几个基因，包括在胃上皮细胞中的II期解毒酶（NADPH-泛醌氧化还原酶，谷胱甘肽S-转移酶）和抗氧化应激蛋白（HO-1，硫氧还蛋白还原酶，和超氧化物歧化酶）的表达。Lansoprazole显著抑制IL-1β刺激的RGM-1细胞中生产CINC-1。在大鼠胃上皮细胞中，Lansoprazole上调HO-1表达，并且有抗炎作用。[2]

体内研究

在大鼠中，Lansoprazole抑制ischemia-reperfusion或indomethacin 诱导的急性炎性反应，以及肠粘膜损伤。Lansoprazole显著抑制ischemia-reperfusion或indomethacin 诱发的肠损伤。Lansoprazol外源施用防止小肠中ischemia-reperfusion或indomethacin 诱导的损伤。[2]

参考文献

[1] Garnett WR, et al. Ann Pharmacother, 1996, 30(12), 1425-1436.

[2] Takagi T, et al. J Clin Biochem Nutr, 2009, 45(1), 9-13.

安全信息

图形或危害标志
提示语	Warning
危险说明	H315 H319 H335
防范说明	P261 P305+P351+P338
WGK	2
RTECS	DD9487500

PHR1390

Supelco

Lansoprazole

Pharmaceutical Secondary Standard; Certified Reference Material

1359.83元/1 G;

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产品说明

一般描述

Lansoprazole is an important proton pump inhibitor and a substituted benzimidazole with antisecretory and antiulcer activities. Its mode of action involves the suppression of gastric acid secretion by specific inhibition of the gastric H⁺/K⁺ ATPase enzyme system at the secretory surface of the gastric parietal cells.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Lansoprazole may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique, kinetic spectrophotometric technique and capillary electrophoresis.

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC3483 in the slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式	C₁₆H₁₄F₃N₃O₂S
分子量	369.36
MDL编号	MFCD00866873
NACRES	NA.24

产品性质

质量水平	300
等级	certified reference material pharmaceutical secondary standard
CofA	current certificate can be downloaded
technique(s)	HPLC: suitable gas chromatography (GC): suitable
application(s)	pharmaceutical (small molecule)
格式	neat
药典可追溯性	traceable to BP 872 traceable to PhEur Y0000773 traceable to USP 1356916
储存温度	2-8℃
SMILES string	Cc1c(CS(=O)c2nc3ccccc3[nH]2)nccc1OCC(F)(F)F
InChI	1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)
InChI key	MJIHNNLFOKEZEW-UHFFFAOYSA-N
Gene Information	human ... ATP4A(495), ATP4B(496)

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319 - H335
预防措施声明	P261 - P305 + P351 + P338
危险分类	Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	13 - Non Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

L8533

Sigma-Aldrich

Lansoprazole

≥98% (TLC), powder

676.58元/250 MG; 2158.12元/1 G;

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产品说明

生化/生理作用

胃质子泵抑制剂。

特点和优势

该化合物由 Novartis 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单，请单击此处。

基本信息

经验(实验)分子式	C₁₆H₁₄F₃N₃O₂S
分子量	369.36
MDL编号	MFCD00866873
PubChem化学物质编号	24278520
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (TLC)
形式	powder
颜色	off-white
创始人	Novartis
储存温度	2-8℃
SMILES string	Cc1c(CS(=O)c2nc3ccccc3[nH]2)nccc1OCC(F)(F)F
InChI	1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)
InChI key	MJIHNNLFOKEZEW-UHFFFAOYSA-N
Gene Information	human ... ATP4A(495), ATP4B(496)

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319 - H335
预防措施声明	P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
危险分类	Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

Y0000773

Lansoprazole

European Pharmacopoeia (EP) Reference Standard

1277.32元/ ;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 60 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₁₆H₁₄F₃N₃O₂S
分子量	369.36
MDL编号	MFCD00866873
PubChem化学物质编号	329831143
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	EDQM
application(s)	pharmaceutical (small molecule)
格式	neat
SMILES string	Cc1c(CS(=O)c2nc3ccccc3[nH]2)nccc1OCC(F)(F)F
InChI	1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)
InChI key	MJIHNNLFOKEZEW-UHFFFAOYSA-N
Gene Information	human ... ATP4A(495), ATP4B(496)

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319 - H335
预防措施声明	P305 + P351 + P338
危险分类	Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	13 - Non Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

Y0000774

Lansoprazole for peak identification

European Pharmacopoeia (EP) Reference Standard

1277.32元/ ;

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产品说明

一般描述

包装

Unit quantity: 1.01 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₁₆H₁₄F₃N₃O₂S
分子量	369.36
MDL编号	MFCD00866873
PubChem化学物质编号	329831144
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	EDQM
application(s)	pharmaceutical (small molecule)
格式	neat
SMILES string	Cc1c(CS(=O)c2nc3ccccc3[nH]2)nccc1OCC(F)(F)F
InChI	1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)
InChI key	MJIHNNLFOKEZEW-UHFFFAOYSA-N
Gene Information	human ... ATP4A(495), ATP4B(496)

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319 - H335
预防措施声明	P302 + P352 - P305 + P351 + P338
危险分类	Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

BP872

Lansoprazole

British Pharmacopoeia (BP) Reference Standard

1861.35元/100 MG;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₁₆H₁₄F₃N₃O₂S
分子量	369.36
MDL编号	MFCD00866873
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	BP
格式	neat
储存温度	2-8℃
SMILES string	Cc1c(CS(=O)c2nc3ccccc3[nH]2)nccc1OCC(F)(F)F
InChI	1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)
InChI key	MJIHNNLFOKEZEW-UHFFFAOYSA-N
Gene Information	human ... ATP4A(495), ATP4B(496)

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319 - H335
预防措施声明	P305 + P351 + P338
危险分类	Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	13 - Non Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

1356916

USP

Lansoprazole

United States Pharmacopeia (USP) Reference Standard

3231.47元/150 MG;

咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式	C₁₆H₁₄F₃N₃O₂S
分子量	369.36
MDL编号	MFCD00866873
PubChem化学物质编号	329750232

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	USP
application(s)	pharmaceutical (small molecule)
格式	neat
SMILES string	Cc1c(CS(=O)c2nc3ccccc3[nH]2)nccc1OCC(F)(F)F
InChI	1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)
InChI key	MJIHNNLFOKEZEW-UHFFFAOYSA-N
Gene Information	human ... ATP4A(495), ATP4B(496)

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319 - H335
预防措施声明	P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
危险分类	Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

BP873

Lansoprazole impurity standard

British Pharmacopoeia (BP) Reference Standard

1916.08元/25 MG;

咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 25 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₁₆H₁₄F₃N₃O₂S
分子量	369.36
MDL编号	MFCD00866873

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	BP
格式	mixture
储存温度	2-8℃
SMILES string	Cc1c(CS(=O)c2nc3ccccc3[nH]2)nccc1OCC(F)(F)F
InChI	1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)
InChI key	MJIHNNLFOKEZEW-UHFFFAOYSA-N
Gene Information	human ... ATP4A(495), ATP4B(496)

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319 - H335
预防措施声明	P261 - P280 - P280 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338
危险分类	Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable