产品说明

一般描述

A 2-arylbenzothiazole compound that acts as an inhibitor against the ATP-dependent Photinus pyralis (lucPpy) and Photuris pennsylvanica (lucPpe) luciferase activity (IC₅₀ = 0.2 and 0.32 µM, respectively, with 10 µM ATP, 10 µM luciferin, and 10 nM respective enzyme). Unlike Luciferase Inhibitor I (Cat. No. 119113), Luciferase Inhibitor II is competitive with respect to luciferin and exhibits reduced potency against lucPpe-based commercial luciferase-luciferin formulations with high luciferin concentration (IC₅₀ = 10 µM against Promega′s Kinase-Glo; ineffective against Kinase-Glo Plus and Kinase-Glo Max; at a 3-fold formulation dilution and 6.77 µM ATP).
A 2-arylbenzothiazole compound that acts as an inhibitor against the ATP-dependent Photinus pyralis (lucPpy) and Photuris pennsylvanica (lucPpe) luciferase activity (IC₅₀ = 0.2 and 0.32 µM, respectively, with 10 µM ATP, 10 µM luciferin, and 10 nM respective enzyme). Unlike Luciferase Inhibitor I (Cat. No. 119113), Luciferase Inhibitor II is competitive with respect to luciferin and exhibits reduced potency against lucPpe-based commercial luciferase-luciferin formulations with high luciferin concentration (IC₅₀ = 10 µM against Promega′s Kinase-Glo; ineffective against Kinase-Glo Plus and Kinase-Glo Max; at a 3-fold formulation dilution and 6.77 µM ATP).

包装

5 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Harmful (C)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Auld, D.S., et al. 2009. J. Med. Chem.52, 1450.
Auld, D.S., et al. 2008. J. Med. Chem.51, 2372.

法律信息

Marketed by Promega Corp. under the registered trademarks.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

产品性质

安全信息

基本信息

安全信息

图形或危害标志
危险性说明	H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .