CAS 10199-89-0; 4-氯-7-硝基苯呋咱; 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole

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C805413

MACKLIN

4-氯-7-硝基-2,1,3-苯并氧杂恶二唑

98%

53元/100mg; 269元/1g; 806元/5g; 2280元/25g;

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储存：2~8°C
状态：黄色粉末

A5592

TCI

NBD-Cl (=4-Chloro-7-nitro-2,1,3-benzoxadiazole) [for HPLC Labeling]

>98.0%(T)

250元/1G; 850元/5G;

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基本信息

纯度/分析方法	>98.0%(T)
分子式/分子量	C₆H₂ClN₃O₃ = 199.55
外观与形状(20℃)	固体
Reaxys-RN	614212
PubChem物质ID	87563199
SDBS (AIST Spectral DB)	5444
MDL编号	MFCD00005808

技术规格

Appearance	Light yellow to Yellow powder to crystal
Purity(Volumetric Analysis)	min. 98.0 %
Melting point	97.0 to 100.0 ℃
Solubility in Methanol	almost transparency

物性(参考值)

熔点

98 ℃

安全信息

图形或危害标志
信号词	警告
危险性说明	H315 : 造成皮肤刺激。 H319 : 造成严重眼刺激。
防范说明	P264 : 作业后彻底清洗皮肤。 P280 : 戴防护手套/戴防护眼罩/戴防护面具。 P302 + P352 : 如皮肤沾染：用水充分清洗。 P337 + P313 : 如仍觉眼刺激：求医/就诊。 P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。 P332 + P313 : 如发生皮肤刺激：求医/就诊。

相关法规

RTECS#

DF8002400

A14165

Alfa Aesar

4-Chloro-7-nitrobenzofurazan

98%

941元/5g;

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应用
4-Chloro-7-nitrobenzofurazan is used as a derivatizing reagent for chromatography analysis of amino acids and low molecular weight amines. It is utilized in the preparation of fluorescent phospholipid-derivative, hydroxynaphthofurazan and 4-chloro-7-nitrobenzofurazan- didecanoylphosphatidylethanolamine. It serves as a fluorescent reagent to label free sulfhydryls and N-terminals within proteins and trapping agent for cysteine sulfenic acid. It is a sensitive chromogenic and fluorogenic reagent. It reacts with trans-1-methoxy-3-(trimethylsilyloxy)-1,3-butadiene (Danishefsky's diene) to prepare regioselectively the silyl enol ether. Further, it is used to label peptides, proteins and other biomolecules. In addition it is used in the synthesis of fluorescent phospholipid-derivative, NBD-didecanoylphosphatidylethanolamine, functionalized hydroxynaphthofurazan and 7-nitrobenzofurazan (NBD)-labeled maleimide.

备注
Store in a cool place. Incompatible with strong oxidizing agents and strong bases.

基本信息

MDL
MFCD00005808

EINECS
233-496-4

分子式
C₆H₂ClN₃O₃

分子量
199.56

熔点
96-100°

灵敏度
Ambient temperatures.

形态
Crystalline powder

溶解性
Soluble in methanol, dimethylsulfoxide, dimethylformamide and chloroform.

Beilstein
614212

GHS危害和防范说明

GHS符号

Hazard Statements
H315-H319-H335
Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
36/37/38
Irritating to eyes, respiratory system and skin.

安全等级
26-37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

RTECS
DF8002400

TSCA
是

163260

Sigma-Aldrich

4-Chloro-7-nitrobenzofurazan

98%

323.5元/1 G; 925.81元/5 G;

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产品说明

一般描述

4-氯-7-硝基苯并呋喃(NBD-Cl)是一种高度灵敏的发色和荧光试剂。据报道，它能与反-1-甲氧基-3-(三甲基硅氧基)-1,3-丁二烯(Danishefsky二烯)发生自发反应，通过正常电子需求的Diels-Alder(NEDDA)反应，区域选择性地生成烯醇硅醚。已有研究对NBD-Cl进行了分子结构、振动光谱和NBO(自然键轨道)分析。它作为柱前衍生剂的用途已被研究。

应用

4-氯-7-硝基苯并呋喃(NBD-氯化物)被用于以下研究：

合成荧光磷脂衍生物，即NBD-二癸酰基磷脂酰乙醇胺
合成官能化羟基萘并呋咱。
药物配方中富马酸氯马斯汀、氯雷他定、氯沙坦钾和雷米普利的分光光度法和荧光分光光度法测定。
通过Diels-Alder反应合成7-硝基苯并呋喃(NBD)-标记的马来酰亚胺。

包装

1, 5 g in glass bottle

基本信息

经验(实验)分子式	C₆H₂ClN₃O₃
分子量	199.55
Beilstein	614212
EC 号	233-496-4
MDL编号	MFCD00005808
PubChem化学物质编号	24849737

产品性质

质量水平	100
测定	98%
形式	powder
mp	97-99 ℃ (lit.)
溶解性	chloroform: soluble 50 mg/mL, clear to slightly hazy, faintly yellow to yellow
SMILES string	[O-][N+](=O)c1ccc(Cl)c2nonc12
InChI	1S/C6H2ClN3O3/c7-3-1-2-4(10(11)12)6-5(3)8-13-9-6/h1-2H
InChI key	IGHBXJSNZCFXNK-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319
预防措施声明	P302 + P352 - P305 + P351 + P338
危险分类	Eye Irrit. 2 - Skin Irrit. 2
储存分类代码	11 - Combustible Solids
WGK	WGK 3
个人防护装备	dust mask type N95 (US), Eyeshields, Faceshields, Gloves

25455

Sigma-Aldrich

4-Chloro-7-nitrobenzofurazan

BioReagent, suitable for fluorescence, ≥97.0% (HPLC)

430.85元/1 G; 1152.45元/5 G; 4589.47元/25 G;

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产品说明

应用

4-氯-7-硝基苯并-2-氧杂-1,3-二唑(NBD-chloride)是一种荧光检测试剂，用于标记蛋白质中的游离巯基和 N-末端。NBD-chloride 可用作酶抑制剂，以及半胱氨酸硫酸的捕获剂。

基本信息

经验(实验)分子式	C₆H₂ClN₃O₃
分子量	199.55
Beilstein	614212
EC 号	233-496-4
MDL编号	MFCD00005808
PubChem化学物质编号	329752738
NACRES	NA.32

产品性质

质量水平	100
产品线	BioReagent
测定	≥97.0% (HPLC)
mp	97-100 ℃ 97-99 ℃ (lit.)
荧光	λ_ex 336 nm in methanol λ_ex 420 nm; λ_em ~540 nm in ethanol (after derivatization with glycine)
适用性	suitable for fluorescence
SMILES string	[O-][N+](=O)c1ccc(Cl)c2nonc12
InChI	1S/C6H2ClN3O3/c7-3-1-2-4(10(11)12)6-5(3)8-13-9-6/h1-2H
InChI key	IGHBXJSNZCFXNK-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319
预防措施声明	P302 + P352 - P305 + P351 + P338
危险分类	Eye Irrit. 2 - Skin Irrit. 2
储存分类代码	11 - Combustible Solids
WGK	WGK 3
个人防护装备	dust mask type N95 (US), Eyeshields, Faceshields, Gloves

221943

Fluorochem

4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole

95%

462元/1g; 1694元/5g;

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基本信息

CAS Number	10199-89-0
MDL Number	MFCD00005808
Melting Point	98℃

安全信息

图形或危害标志
危险性说明	H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .