产品说明 应用 Zardaverine has been used as a phosphodiesterase inhibitor: - to study its effects on human colonic epithelial cells
- to study its effects on junctional proteins in Sertoli cells
- to study its effects on phosphodiesterase 3 A (PDE3A) expression in various tumor cells
生化/生理作用 Zardaverine is a derivative of pyridazinone. It shows anti-tumor and anti-proliferative activity in varied cell lines. Zardaverine possesses broncho-dilatory activity and exhibits therapeutic effects against asthma.
Selective inhibitor of phosphodiesterase III/IV (PDE3/4). 基本信息 | 经验(实验)分子式 | C12H10F2N2O3 | | 分子量 | 268.22 | | MDL编号 | MFCD00867059 | | PubChem化学物质编号 | 24278784 | | NACRES | NA.77 |
产品性质 | 质量水平 | 200 | | 生物来源 | synthetic (organic) | | 测定 | ≥98% (HPLC) | | 形式 | powder | | 效能 | 1.1 μM IC50 (for PDE IV)
2.5 μM IC50 (for PDE III) | | SMILES string | COc1cc(ccc1OC(F)F)C2=NNC(=O)C=C2 | | InChI | 1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17) | | InChI key | HJMQDJPMQIHLPB-UHFFFAOYSA-N | | Gene Information | human ... PDE3A(5139), PDE3B(5140), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144), PDE5A(8654), PDE7A(5150)
rat ... Pde2a(81743), Pde4a(25638) |
安全信息 | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable | | 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
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