试剂仪器设备原料
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细胞培养基 >> 细胞株
NIH:OVCAR-3人卵巢癌细胞
NIH:OVCAR-3人卵巢癌细胞图片
产品介绍
目录号
Serial
TCHu228
标识符
Identifier
CSTR:19375.09.3101HUMTCHu228
描述
Description
NIH-OVCAR-3细胞由T.C.Hamilton在1982年建系。 取材于患进行性卵巢腺癌病人的恶性腹水。 与107细胞联合皮下接种5只裸鼠21天后全部成瘤。 NIH-OVCAR-3是研究卵巢癌药物抗性的一个合适的模型系统且由于存在激素受体,这对于激素治疗的评估或许是有用的。
预定此细胞需至少提前两周。
在本库通过支原体检测。
在本库通过STR检测。
动物种别
Organism
性别
Gender
组织来源
Tissue and Cell Type
器官:卵巢疾病:腺癌细胞类型:上皮细胞
形态
Morphology
上皮细胞
培养基和添加剂
Complete Growth Medium and Culture Conditions
RPMI 1640培养基(GIBCO by life technologies ,货号C11875500BT),添加0.01毫克/毫升牛胰岛素,80%;优质胎牛血清,20%。
气相:空气,95%;二氧化碳,5%。
温度:37摄氏度。
供应限制
Permits and Restrictions
A。仅供研究之用。
REFERENCEHamilton TC , et al. Characterization of a human ovarian carcinoma cell line (NIH:OVCAR-3) with androgen and estrogen receptors. Cancer Res. 43: 5379-5389, 1983. PubMed: 6604576Hamilton TC , et al. Induction of progesterone receptor with 17beta-estradiol in human ovarian cancer. J. Clin. Endocrinol. Metab. 59: 561-563, 1984. PubMed: 6746867Rogan AM , et al. Reversal of adriamycin resistance by verapamil in human ovarian cancer. Science 224: 994-996, 1984. PubMed: 6372095Hamilton TC , et al. Characterization of a xenograft model of human ovarian carcinoma which produces ascites and intraabdominal carcinomatosis in mice. Cancer Res. 44: 5286-5290, 1984. PubMed: 6333272Green JA , et al. Potentiation of melphalan cytotoxicity in human ovarian cancer cell lines by glutathione depletion. Cancer Res. 44: 5427-5431, 1984. PubMed: 6488194Caffrey PB , Frenkel GD . Selenite cytotoxicity in drug resistant and nonresistant human ovarian tumor cells. Cancer Res. 52: 4812-4816, 1992. PubMed: 1511444Hamilton TC , et al. Experimental model systems of ovarian cancer: applications to the design and evaluation of new treatment approaches. Semin. Oncol. 11: 285-298, 1984. PubMed: 6385258Godwin AK , et al. High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis. Proc. Natl. Acad. Sci. USA 89: 3070-3074, 1992. PubMed: 1348364Chang K , Pastan I . Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. Proc. Natl. Acad. Sci. USA 93: 136-140, 1996. PubMed: 8552591Omelyanenko V , et al. HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. II. Processing in epithelial ovarian carcinoma cells in vitro. Int. J. Cancer 75: 600-608, 1998. PubMed: 9466663
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