CAS 93882-12-3; 8-(4-chlorophenylthio)adenosine-3',5'-cyclic monophosphate(8-cpt-camp),sodium salt

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C913147

MACKLIN

8-CPT-Cyclic AMP sodium salt

98%

2998元/50mg;

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储存：-20°C，密闭，干燥
状态：白色固体

116812

Sigma-Aldrich

Adenosine 3',5'-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt-CAS 93882-12-3-Calbiochem

Cell-permeable cAMP analog that activates both protein kinase A and protein kinase G.

862.79元/10 MG;

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产品说明

一般描述

Cell-permeable cAMP analog that activates both protein kinase A and protein kinase G. Directly activates Epac, a Rap1 guanine-nucleotide exchange factor. Also acts as a potent inhibitor of cGMP-specific phosphodiesterase (IC₅₀ = 900 nM). Inhibits cAMP-specific phosphodiesterase at much higher concentrations (IC₅₀ = 25 µM).
Cell-permeable cAMP analog that activates both protein kinase A and protein kinase G. Induces the guanine-nucleotide-exchange factor activity of EGFI, also known as Epac (exchange protein directly activated by cAMP), and EGFII towards Rap1 both in vivo and in vitro. Also acts as a potent inhibitor of cGMP specific phosphodiesterase (IC₅₀ = 900 nM). Also inhibits cAMP-specific phosphodiesterases at much higher concentrations (IC₅₀ = 25 µM).

包装

10 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Target IC₅₀: 900 nM against cGMP-specific phosphodiesterase
Product does not compete with ATP.
Reversible: no
Primary Target
Protein kinase A and protein kinase G

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C

其他说明

de Rooij, J., et al. 1998. Nature.396, 474.
Kawasaki, H., et al. 1998. Science.282, 2275.
Moed, P.J., et al. 1993. Comp. Biochem. Physiol.105A, 711.
Connolly, B.J., et al. 1992. Biochem. Pharmacol.44, 2303.
Phillips, M.E., and Taylor, A. 1992. J. Physiol.456, 591.
Shipston, M.J., and Antoni, F.A. 1992. Endocrinology130, 2213.
Datta, R., et al. 1991. Blood78, 83.
Peters, D.J.M., et al. 1991. Proc. Natl. Acad. Sci. USA88, 9219.
Sandberg, M., et al. 1991. Biochem. J.279, 521.
Unterman, T.G., et al. 1991. Endocrinology128, 2693.
Xu, H., et al. 1989. Brain Res.504, 36.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₆H₁₄ClN₅O₆PS · Na
分子量	493.79
MDL编号	MFCD00057683

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze desiccated (hygroscopic)
颜色	white
溶解性	water: 10 mg/mL
运输	ambient
储存温度	−20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

C3912

Sigma-Aldrich

8-(4-Chlorophenylthio)adenosine 3′,5′-cyclic monophosphate sodium salt

≥97.0% (HPLC), powder

1081.94元/10 MG; 3154.07元/50 MG; 5400.88元/100 MG;

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产品说明

应用

8-(4-硫代氯苯基)腺苷3′5′-环状-单磷酸钠盐用于：

上调细胞胆固醇泵(三磷酸腺苷(ATP)结合盒(ABC)转运蛋白1，ABCA-1)
葡萄糖生成测定
刺激气道上皮细胞的囊性纤维化跨膜传导调节因子(CFTR)通道

包装

10 mg in glass bottle
50, 100 mg in poly bottle

生化/生理作用

膜通透性 cAMP 类似物。用作 cAMP 依赖性蛋白激酶 (PKA) 的选择性激活剂。抑制 cGMP 依赖性磷酸二酯酶，在较高浓度时，抑制 cAMP 依赖性磷酸二酯酶。抑制 n-甲酰-Met-Leu-Phe 刺激的磷酸肌醇水解和分泌，但不抑制白细胞中的血小板活化因子。使 HL-60 细胞更能抵抗 NO 诱导的 DNA 损伤。

特点和优势

这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

基本信息

经验(实验)分子式	C₁₆H₁₄ClN₅NaO₆PS
分子量	493.79
EC 号	299-413-9
MDL编号	MFCD00057683
PubChem化学物质编号	24278024
NACRES	NA.77

产品性质

质量水平	200
测定	≥97.0% (HPLC)
形式	powder
颜色	white
溶解性	H₂O: 25 mg/mL
储存温度	−20℃
SMILES string	[Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)c(Sc5ccc(Cl)cc5)nc12
InChI	1S/C16H15ClN5O6PS.Na/c17-7-1-3-8(4-2-7)30-16-21-10-13(18)19-6-20-14(10)22(16)15-11(23)12-9(27-15)5-26-29(24,25)28-12;/h1-4,6,9,11-12,15,23H,5H2,(H,24,25)(H2,18,19,20);/q;+1/p-1/t9-,11-,12-,15-;/m1./s1
InChI key	YIJFVHMIFGLKQL-DNBRLMRSSA-M
Gene Information	human ... PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)