CAS 900305-37-5; pfi-4

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CAS:

900305-37-5

分子式:

C₂₁H₂₄N₄O₃

分子量:

380.44

英文名称:

pfi-4

pf-05363047

n-(1,3-dimethyl-2-oxo-6-pyrrolidin-1-ylbenzimidazol-5-yl)-2-methoxybenzamide

n-[2,3-dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1h-benzimidazol-5-yl]-2-methoxy-benzamide

用途:

PFI-4是一种有效的选择性BRPF1 bromodomain抑制剂，IC50为80 nM。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

P797326

MACKLIN

PFI-4

10mM in DMSO

610元/1ml;

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储存：-20°C

P872488

MACKLIN

PFI-4

99%

390元/5mg;

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储存：-20℃
状态：粉末

2062538

J&K

PFI-4

98%, 一种有效的, 渗透细胞的选择性BRPF1 Bromodoman抑制剂, IC50为 80 Nm, 作用于BRPF1比作用于其他Bromodoman (包括BRPF2/3和BRD4) 选择性强100多倍

618元/5MG; 827元/10MG;

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基本信息

分子式	C₂₁H₂₄N₄O₃
分子量	380.44
存储条件	Freezer -20℃

产品描述

PFI-4是一种有效的选择性BRPF1 bromodomain抑制剂，IC50为80 nM。

靶点（IC50 & Targe）

BRPF1,80nM

BRPF2,7.9μM

BRPF3,>10μM

体外研究

PFI-4 is cell permeable, and acts by displacing the BRPF1 bromodomain from Histone H3.3. [1]

参考文献

[1] Demont EH, et al. ACS Med Chem Lett. 2014, 5(11), 1190-11

PZ0307

Sigma-Aldrich

PFI-4

≥98% (HPLC)

1117.23元/5 MG; 4498.97元/25 MG;

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产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

PFI-4 is an SGC chemical probe for the bromodomains of the BRPF (BRomodomain and PHD Finger containing) scaffolding protein BRPF1B. The BRPF proteins (BRPF1/2/3) assemble histone acetyltransferase (HAT) complexes of the MYST transcriptional coactivator family members MOZ and MORF. The BRPF1 protein is the scaffold subunit of the MYST acetyltransferase complex, which plays a crucial roles in DNA repair, recombination and replication as well as transcription activation. Mutations in MOZ, MORF, and BRPF1 have all been associated with cancer. BRPF1 exists in 2 different isoforms: BRPF1A and BRPF1B. PFI-4 specifically binds to BRPF1B with a Kd =13 nM as determined by ITC. It reduces recovery time in triple BRD cell construct in FRAP and is potent in cells with IC50 250nM, while showing no effect on BRPF1A. For full characterization details, please visit the PFI-4 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

特点和优势

PFI-4 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

其他说明

This compound was developed by Pfizer for Gene Regulation research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

基本信息

经验(实验)分子式	C₂₁H₂₄N₄O₃
分子量	380.44
PubChem化学物质编号	329823828
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
manufacturer/tradename	Pfizer^®
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear (warmed)
创始人	Pfizer
储存温度	room temp
SMILES string	CN(C1=CC(NC(C2=C(OC)C=CC=C2)=O)=C(N3CCCC3)C=C1N4C)C4=O
InChI	1S/C21H24N4O3/c1-23-17-12-15(22-20(26)14-8-4-5-9-19(14)28-3)16(25-10-6-7-11-25)13-18(17)24(2)21(23)27/h4-5,8-9,12-13H,6-7,10-11H2,1-3H3,(H,22,26)
InChI key	QCIJLRJBZDBVDB-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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