| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 |
| S0509 | TCI | Simvastatin | >97.0%(HPLC) | 200元/100MG; 715元/1G; | 展开 |
基本信息 | 纯度/分析方法 | >97.0%(HPLC) | | 分子式/分子量 | C25H38O5 = 418.57 | | 外观与形状(20℃) | 固体 | | 储存在惰性气体下 | 存放于惰性气体之中 | | 应避免的情况 | 空气,湿气 (吸湿) | | Reaxys-RN | 4768037 | | PubChem物质ID | 87558834 | | Merck Index (14) | 8539 | | MDL编号 | MFCD00072007 |
技术规格 | Appearance | White to Almost white powder to crystal | | Purity(HPLC) | min. 97.0 area% | | Melting point | 132.0 to 137.0 ℃ | | Specific rotation [a]20/D | +285 to +300 deg(C=1, CH3CN) |
物性(参考值) | 熔点 | 134 ℃ | | 比旋光度 [α]D | 293° (C=1,CH3CN) | | 溶解性(可溶于) | 氯仿 |
安全信息 | 信号词 | 警告 | | 危险性说明 | H303 : 吞咽可能有害。
| | 防范说明 | P312 : 如感觉不适，呼叫急救中心/医生。
|
相关法规 |
| 227935 | J&K | Simvastatin | 97%, HMG-CoA还原酶抑制剂 | 171元/100MG; 618元/1G; | 展开 |
基本信息 | 分子式 | C25H38O5 | | 分子量 | 418.57 | | 熔点 | 127-132 | | 比旋光度([α]20D) | +285 to +300 (C=1, CH3CN) | | MDL编码 | MFCD00072007 | | Beilstein | 4768037 | | Merck | 14,8539 | | 存储条件 | Freezer -20℃ |
安全信息 |
| C45884 | Alfa Aesar | Simvastatin | 98% | 785元/1g; 1416元/5g; 4664元/25g; | 展开 |
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| R11037 | Alfa Aesar | Simvastatin Standard solution | 100ppm | 210元/1ml; | 展开 |
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| PHR1438 | Supelco | Simvastatin | Pharmaceutical Secondary Standard; Certified Reference Material | 1471.28元/1 G; | 展开 |
产品说明 一般描述 用于质量控制的经认证的药物二级标准品为制药实验室和制造商提供了一种方便且高性价比的药典一级标准品的替代品。
辛伐他汀是一种降血脂药物，其通过抑制3-羟基-3-甲基-戊二酰辅酶 A(HMG-CoA)而降低血浆胆固醇。它广泛应用于高胆固醇血症的治疗。 应用 辛伐他汀可用作药物参考标准品，用于通过各种色谱技术测定药物制剂中的分析物。
这些二级标准品是合格的认证标准物质(CRM)。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。 生化/生理作用 辛伐他汀是HMG-CoA还原酶的特异性抑制剂，HMG-CoA还原酶是催化HMG-CoA转化为甲羟戊酸的酶，其是胆固醇生物合成的早期步骤。由于它可以降低低密度脂蛋白和甘油三酯的水平，并提高高密度脂蛋白水平，因而可用于治疗高胆固醇血症。辛伐他汀是一种内酯，其在体内 易于水解成相应的β-羟基酸，并可以在使用前用溶于EtOH中的NaOH进行活化。它是洛伐他汀的合成类似物(货M2147)。 分析说明 这些二级标准品可追溯至USP、EP和BP一级标准品。 其他说明 该认证参考物质(CRM)根据 ISO 17034 和 ISO/IEC 17025 进行生产和认证。所有关于此 CRM 的信息都可以在分析证书上找到。 附注 要查看该材料的分析证书示例，请在下面的栏位中输入 LRAB3719 。这只是一个示例证书，可能不是您收到的批次。 基本信息 | 经验(实验)分子式 | C25H38O5 | | 分子量 | 418.57 | | MDL编号 | MFCD00072007 | | PubChem化学物质编号 | 329822601 | | NACRES | NA.24 |
产品性质 | 质量水平 | 300 | | 等级 | certified reference material
pharmaceutical secondary standard | | CofA | current certificate can be downloaded | | technique(s) | HPLC: suitable
gas chromatography (GC): suitable | | mp | 127-132 ℃ (lit.) | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | 药典可追溯性 | traceable to BP 739
traceable to PhEur S0650000
traceable to USP 1612700 | | 储存温度 | -10 to -25℃ | | SMILES string | [H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)OC(=O)C(C)(C)CC | | InChI | 1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1 | | InChI key | RYMZZMVNJRMUDD-HGQWONQESA-N | | Gene Information | human ... HMGCR(3156) |
安全信息 | 象形图 |  | | 警示用语： | Warning | | 危险声明 | H361d | | 预防措施声明 | P201 - P202 - P280 - P308 + P313 - P405 - P501 | | 危险分类 | Repr. 2 | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
|
| S0650000 | | Simvastatin | European Pharmacopoeia (EP) Reference Standard | 1277.32元/ ; | 展开 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia. 生化/生理作用 辛伐他汀是HMG-CoA还原酶的特异性抑制剂，HMG-CoA还原酶是催化HMG-CoA转化为甲羟戊酸的酶，其是胆固醇生物合成的早期步骤。由于它可以降低低密度脂蛋白和甘油三酯的水平，并提高高密度脂蛋白水平，因而可用于治疗高胆固醇血症。辛伐他汀是一种内酯，其在体内 易于水解成相应的β-羟基酸，并可以在使用前用溶于EtOH中的NaOH进行活化。它是洛伐他汀的合成类似物(货M2147)。 包装 Unit quantity: 200 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue. 注意 Please find SDS provided by EDQM here.. 其他说明 Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C25H38O5 | | 分子量 | 418.57 | | MDL编号 | MFCD00072007 | | PubChem化学物质编号 | 329824434 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | EDQM | | technique(s) | HPLC: suitable
gas chromatography (GC): suitable | | mp | 127-132 ℃ (lit.) | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | SMILES string | [H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)OC(=O)C(C)(C)CC | | InChI | 1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1 | | InChI key | RYMZZMVNJRMUDD-HGQWONQESA-N | | Gene Information | human ... HMGCR(3156) |
安全信息 | 象形图 | | | 警示用语： | Warning | | 危险声明 | H361d | | 预防措施声明 | P201 - P202 - P280 - P308 + P313 - P405 - P501 | | 危险分类 | Repr. 2 | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| 567020 | Sigma-Aldrich | Simvastatin-CAS 79902-63-9-Calbiochem | A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. | 3736.22元/50 MG; | 展开 |
产品说明 一般描述 A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+ signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. Note: this product is supplied in an inactive form and requires treatment with NaOH in EtOH followed by neutralization to pH 7.2 for activation.
A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+-signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. Note: This product is supplied in an inactive form and requires treatment with NaOH in ethanol followed by neutralization to pH 7.2 for activation. 包装 50 mg in Plastic ampoule 生化/生理作用 Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
farnesylation 警告 Toxicity: Standard Handling (A) 制备说明 Dissolve 50 mg in 1 ml in ethanol and add 0.813 ml of 1N NaOH. Adjust the pH to 7.2 by adding small quantities of 1N HCl before use. 重悬 Following reconstitution in ethanol-NaOH, aliquot and freeze (-20°C) Ethanol-NaOH solutions are stable for up to 1 month at -20°C. Neutralized solutions should be used immediately. 其他说明 Yada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
Keyomarsi, K., et al. 1991. Cancer Res.51, 3602. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息 | 经验(实验)分子式 | C25H38O5 | | 分子量 | 418.57 | | MDL编号 | MFCD00072007 |
产品性质 | 质量水平 | 100 | | 测定 | ≥98% (HPLC) | | 形式 | solid | | manufacturer/tradename | Calbiochem® | | 储存条件 | OK to freeze | | 颜色 | off-white | | 痕量阳离子 | heavy metals: ≤20 ppm
heavy metals: <20 ppm | | 运输 | ambient | | 储存温度 | 2-8℃ | | InChI | 1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1 | | InChI key | RYMZZMVNJRMUDD-HGQWONQESA-N |
安全信息 | 象形图 | | | 警示用语： | Warning | | 危险声明 | H361d | | 预防措施声明 | P201 - P202 - P280 - P308 + P313 - P405 - P501 | | 危险分类 | Repr. 2 | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| S6196 | Sigma-Aldrich | Simvastatin | ≥97% (HPLC), solid | 616.99元/5 MG; 2280.72元/25 MG; | 展开 |
产品说明 一般描述 辛伐他汀是药物前体。辛伐他汀是洛伐他汀的半合成衍生物/类似物。辛伐他汀不溶于水，但可溶于极性有机溶剂。 应用 辛伐他汀已用于：
- 用于 HMG CoA还原酶(HMGCR)的抑制剂
- 研究其对上皮间质转化(EMT)以及肺腺癌患者预后的影响
- 体内研究检验其对脑肿瘤−启动细胞(BTIC)活力和细胞增殖的影响
- 研究三磷酸腺苷(ATP)-结合盒转运蛋白A7在Jurkat细胞吞噬作用中的作用
- 研究其对小鼠内皮功能障碍和炎症的影响
包装 5 mg in glass bottle
25 mg in poly bottle 生化/生理作用 辛伐他汀是HMG-CoA还原酶的特异性抑制剂，HMG-CoA还原酶是催化HMG-CoA转化为甲羟戊酸的酶，其是胆固醇生物合成的早期步骤。由于它可以降低低密度脂蛋白和甘油三酯的水平，并提高高密度脂蛋白水平，因而可用于治疗高胆固醇血症。辛伐他汀是一种内酯，其在体内 易于水解成相应的β-羟基酸，并可以在使用前用溶于EtOH中的NaOH进行活化。它是洛伐他汀的合成类似物(货M2147)。
辛伐他汀是HMG-CoA还原酶的特异性抑制剂，HMG-CoA还原酶是催化HMG-CoA转化为甲羟戊酸的酶，其是胆固醇生物合成的早期步骤。由于它可以降低低密度脂蛋白胆固醇和甘油三酯的水平，并提高高密度脂蛋白水平，因而可用于治疗高胆固醇血症。辛伐他汀是一种内酯，其在体内易于水解成相应的β-羟基酸，并可以在使用前用溶于EtOH中的NaOH进行活化。它还可能对内皮功能、炎症、平滑肌细胞功能、血管壁功能\止血和LDL氧化具有有益作用。 特点和优势 该化合物是由Merck & Co., Inc., Kenilworth, NJ, U.S.开发的。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单， 请单击此处。 基本信息 | 经验(实验)分子式 | C25H38O5 | | 分子量 | 418.57 | | MDL编号 | MFCD00072007 | | PubChem化学物质编号 | 24724617 | | NACRES | NA.77 |
产品性质 | 质量水平 | 100 | | 测定 | ≥97% (HPLC) | | 形式 | solid | | 颜色 | white | | mp | 127-132 ℃ (lit.) | | 溶解性 | DMSO: ≥20 mg/mL | | web metadata keyword.default | HMG-CoA inhibitor; HMG-CoA; mevalonic; mevalonate; isoprenoid; isoprenoids; reductase; ldl oxidation; vascular wall function | | 创始人 | Merck & Co., Inc., Kenilworth, NJ, U.S. | | 储存温度 | 2-8℃ | | SMILES string | [H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)OC(=O)C(C)(C)CC | | InChI | 1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1 | | InChI key | RYMZZMVNJRMUDD-HGQWONQESA-N | | Gene Information | human ... HMGCR(3156)
rat ... Hmgcr(25675) |
安全信息 | 象形图 | | | 警示用语： | Warning | | 危险声明 | H361d | | 预防措施声明 | P201 - P202 - P280 - P308 + P313 - P405 - P501 | | 危险分类 | Repr. 2 | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable | | 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
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| Y0002069 | | Simvastatin | European Pharmacopoeia (EP) Reference Standard | 1368.62元/ ; | 展开 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia. 生化/生理作用 辛伐他汀是HMG-CoA还原酶的特异性抑制剂，HMG-CoA还原酶是催化HMG-CoA转化为甲羟戊酸的酶，其是胆固醇生物合成的早期步骤。由于它可以降低低密度脂蛋白和甘油三酯的水平，并提高高密度脂蛋白水平，因而可用于治疗高胆固醇血症。辛伐他汀是一种内酯，其在体内 易于水解成相应的β-羟基酸，并可以在使用前用溶于EtOH中的NaOH进行活化。它是洛伐他汀的合成类似物(货M2147)。 包装 Unit quantity: 5 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue. 其他说明 Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C25H38O5 | | 分子量 | 418.57 | | MDL编号 | MFCD00072007 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | EDQM | | mp | 127-132 ℃ (lit.) | | 格式 | neat | | 储存温度 | 2-8℃ | | SMILES string | [H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)OC(=O)C(C)(C)CC | | InChI | 1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1 | | InChI key | RYMZZMVNJRMUDD-HGQWONQESA-N | | Gene Information | human ... HMGCR(3156) |
安全信息 | 象形图 | | | 警示用语： | Warning | | 危险声明 | H361d | | 预防措施声明 | P201 - P202 - P280 - P308 + P313 - P405 - P501 | | 危险分类 | Repr. 2 | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| 38956 | Supelco | Simvastatin | analytical standard | 1880.08元/10 MG; | 展开 |
产品说明 应用 有关合适仪器技术的更多信息，请参考产品分析证书。如需进一步支持，请联系技术服务。 生化/生理作用 辛伐他汀是HMG-CoA还原酶的特异性抑制剂，HMG-CoA还原酶是催化HMG-CoA转化为甲羟戊酸的酶，其是胆固醇生物合成的早期步骤。由于它可以降低低密度脂蛋白和甘油三酯的水平，并提高高密度脂蛋白水平，因而可用于治疗高胆固醇血症。辛伐他汀是一种内酯，其在体内 易于水解成相应的β-羟基酸，并可以在使用前用溶于EtOH中的NaOH进行活化。它是洛伐他汀的合成类似物(货M2147)。 基本信息 | 经验(实验)分子式 | C25H38O5 | | 分子量 | 418.57 | | MDL编号 | MFCD00072007 | | PubChem化学物质编号 | 329755810 | | NACRES | NA.24 |
产品性质 | 质量水平 | 100 | | 等级 | analytical standard | | 测定 | ≥98.0% (HPLC) | | 旋光性 | [α]/D +275±25°, c = 1 in acetonitrile | | 保质期 | limited shelf life, expiry date on the label | | technique(s) | HPLC: suitable
gas chromatography (GC): suitable | | 杂质 | ≤0.5% water | | mp | 127-132 ℃ (lit.) | | application(s) | forensics and toxicology
pharmaceutical (small molecule)
veterinary | | 格式 | neat | | 储存温度 | 2-8℃ | | SMILES string | [H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)OC(=O)C(C)(C)CC | | InChI | 1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1 | | InChI key | RYMZZMVNJRMUDD-HGQWONQESA-N | | Gene Information | human ... HMGCR(3156) |
安全信息 | 象形图 | | | 警示用语： | Warning | | 危险声明 | H361d | | 预防措施声明 | P201 - P202 - P280 - P308 + P313 - P405 - P501 | | 危险分类 | Repr. 2 | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| 1612700 | USP | Simvastatin | United States Pharmacopeia (USP) Reference Standard | 3231.47元/200 MG; | 展开 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia. 生化/生理作用 辛伐他汀是HMG-CoA还原酶的特异性抑制剂，HMG-CoA还原酶是催化HMG-CoA转化为甲羟戊酸的酶，其是胆固醇生物合成的早期步骤。由于它可以降低低密度脂蛋白和甘油三酯的水平，并提高高密度脂蛋白水平，因而可用于治疗高胆固醇血症。辛伐他汀是一种内酯，其在体内 易于水解成相应的β-羟基酸，并可以在使用前用溶于EtOH中的NaOH进行活化。它是洛伐他汀的合成类似物(货M2147)。 分析说明 These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind. 其他说明 USP issued SDS can be found here.
Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C25H38O5 | | 分子量 | 418.57 | | MDL编号 | MFCD00072007 | | PubChem化学物质编号 | 329751099 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | USP | | technique(s) | HPLC: suitable
gas chromatography (GC): suitable | | mp | 127-132 ℃ (lit.) | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | SMILES string | [H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)OC(=O)C(C)(C)CC | | InChI | 1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1 | | InChI key | RYMZZMVNJRMUDD-HGQWONQESA-N | | Gene Information | human ... HMGCR(3156) |
安全信息 | 象形图 | | | 警示用语： | Warning | | 危险声明 | H361d | | 预防措施声明 | P201 - P202 - P280 - P308 + P313 - P405 - P501 | | 危险分类 | Repr. 2 | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| BP739 | | Simvastatin | British Pharmacopoeia (BP) Reference Standard | 1897.81元/100 MG; | 展开 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia. 生化/生理作用 辛伐他汀是HMG-CoA还原酶的特异性抑制剂，HMG-CoA还原酶是催化HMG-CoA转化为甲羟戊酸的酶，其是胆固醇生物合成的早期步骤。由于它可以降低低密度脂蛋白和甘油三酯的水平，并提高高密度脂蛋白水平，因而可用于治疗高胆固醇血症。辛伐他汀是一种内酯，其在体内 易于水解成相应的β-羟基酸，并可以在使用前用溶于EtOH中的NaOH进行活化。它是洛伐他汀的合成类似物(货M2147)。 包装 Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia 其他说明 Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C25H38O5 | | 分子量 | 418.57 | | MDL编号 | MFCD00072007 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | BP | | mp | 127-132 ℃ (lit.) | | 格式 | neat | | 储存温度 | −20℃ | | SMILES string | [H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)OC(=O)C(C)(C)CC | | InChI | 1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1 | | InChI key | RYMZZMVNJRMUDD-HGQWONQESA-N | | Gene Information | human ... HMGCR(3156) |
安全信息 | 象形图 | | | 警示用语： | Warning | | 危险声明 | H361d | | 预防措施声明 | P201 - P202 - P280 - P308 + P313 - P405 - P501 | | 危险分类 | Repr. 2 | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| M03997 | Fluorochem | Simvastatin | 95% | 264元/1g; 484元/5g; 792元/10g; 1650元/25g; | 展开 |
基本信息 | CAS Number | 79902-63-9 | | MDL Number | MFCD00072007 | | Melting Point | 132-137 ℃ |
安全信息 | 图形或危害标志 |  | | 危险性说明 | H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
| | 防范说明 | P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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