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CAS: 747-36-4
分子式: C18H26ClN3O
分子量: 335.88
沸点: 516.7°C
熔点: 240℃
中文名称: 
硫酸羟氯喹
英文名称: 
2-((4-((7-chloro-4-quinolinyl)amino)pentyl)ethylamino)ethanol sulfate (1:1) (
2-((4-((7-chloro-4-quinolyl)amino)pentyl)ethylamino)-ethano sulfate (1:1)
hydroxychloroquine sulfate
plaquenil sulfate
7-Chloro-4-[4-[ethyl-(2-hydroxyethyl)amino]-1-methylbutylamino]quinoline
2-((4-((7-chloro-4-quinolinyl)amino)pentyl)ethylamino)-ethano sulfate (1:1)
性质描述: 白色结晶性粉未,溶解于水中。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
H843752MACKLIN硫酸羟基氯喹98%28元/250mg;   30元/1g;   85元/5g;   293元/25g;   979元/100g;   3604元/500g;   展开
储存:室温,干燥
状态:灰白色固体
H797954MACKLIN硫酸羟基氯喹10mM in H2O485元/1ml;   展开
储存:-20°C, 密封, 干燥
H1306TCIHydroxychloroquine Sulfate>98.0%(HPLC)(N)595元/5G;   1545元/25G;   展开

基本信息

纯度/分析方法>98.0%(HPLC)(N)
分子式/分子量C18H26ClN3O・H2SO4 = 433.95
外观与形状(20℃)固体
相关CAS RN118-42-3
Reaxys-RN7242072
PubChem物质ID125307498
SDBS (AIST Spectral DB)52824
Merck Index (14)4818
MDL编号MFCD00078203

技术规格

AppearanceWhite to Light yellow powder to crystal
Purity(HPLC)min. 98.0 area%
Purity(with Total Nitrogen)min. 98.0 %

安全信息

图形或危害标志
信号词警告
危险性说明H302 : 吞咽有害。
H319 : 造成严重眼刺激。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护眼罩/戴防护面具。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P301 + P312 + P330 : 如误吞咽:如感觉不适,呼叫急救中心/医生。漱口。

相关法规

RTECS#KK3342500
969031J&KHydroxychloroquine Sulfate98%150元/100MG;   展开

基本信息

分子式C18H26ClN3O · H2SO4
分子量433.95
MDL编码MFCD00078203
EINECS 编号212-019-3

安全信息

图形或危害标志
提示语Warning
危险说明H302
H319
防范说明P270
P264
P280
P337+P313
P305+P351+P338
P301+P312+P330
WGK3
RTECSKK3342500
C26301Alfa AesarHydroxychloroquine Sulfate98%1971元/25g;   8211元/100g;   展开

基本信息

Ref#
26301

MDL
78203

分子式
C18 H26 Cl N3 O . H2 S O4

分子量
433.96

PHR1782SupelcoHydroxychloroquine SulfatePharmaceutical Secondary Standard; Certified Reference Material3688.3元/1 G;   展开

产品说明

一般描述

硫酸羟氯喹(Hydroxychloroquine Sulphate)是一种4-氨基喹啉抗病毒药物羟氯喹(HCQ,Plaquenil)的盐。
用于质量控制的药物二级标准品,为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。

应用

硫酸羟氯喹可用作药物二级标准品,用于通过各种分析技术测定药物制剂和生物样品中的分析物。
这些二级标准品经过认证为有证标准物质。它们适用于多种分析应用,包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。

生化/生理作用

硫酸羟氯喹是一种抗炎(通过肿瘤坏死因子)、疾病调节抗风湿药物(DMARD)和血红素聚合酶抑制剂。 它可用于治疗疟疾。

分析说明

这些二级标准品可溯源到USP、EP和BP一级标准品。

其他说明

该认证参考物质(CRM)根据ISO 17034ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在分析证书上找到。

附注

要查看此物质的示例分析证书,请在下面的对话框中输入LRAC0287。这只是一个示例证书,可能与您收到的批次不符。

基本信息

经验(实验)分子式C18H26ClN3O · H2SO4
分子量433.95
EC 号212-019-3
MDL编号MFCD00078203
PubChem化学物质编号329823611
NACRESNA.24

产品性质

质量水平300
生物来源synthetic
等级certified reference material
pharmaceutical secondary standard
agencyBP
EP
USP
形式powder or crystals
CofAcurrent certificate can be downloaded
包装pkg of 1 g
储存条件protect from light
technique(s)HPLC: suitable
gas chromatography (GC): suitable
颜色 white to off-white
pH值(酸碱度)3.5-5.5 (1% in aqueous solution, pH <6.0)
mp238-241 ℃
溶解性chloroform: practically insoluble
ethanol: practically insoluble
ether: practically insoluble
water: soluble
application(s)pharmaceutical (small molecule)
药典可追溯性traceable to BP 1100
traceable to USP 1327000
运输ambient
储存温度2-30℃
SMILES stringOS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12
InChI1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
InChI keyJCBIVZZPXRZKTI-UHFFFAOYSA-N
Gene Informationhuman ... TLR7(51284), TLR9(54106)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H315 - H319
预防措施声明P301 + P312 + P330 - P305 + P351 + P338
危险分类Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
1327000USPHydroxychloroquine SulfateUnited States Pharmacopeia (USP) Reference Standard3231.47元/200 MG;   展开

产品说明

一般描述

Hydroxychloroquine Sulfate (Hydroxychloroquine Sulphate) is a salt of hydroxychloroquine (HCQ, Plaquenil), a 4-aminoquinoline based antiviral drug.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Hydroxychloroquine Sulfate can be used as a pharmaceutical primary standard for the determination of the analyte in pharmaceutical formulations, and biological samples by various analytical techniques.

生化/生理作用

硫酸羟氯喹是一种抗炎(通过肿瘤坏死因子)、疾病调节抗风湿药物(DMARD)和血红素聚合酶抑制剂。 它可用于治疗疟疾。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C18H26ClN3O · H2SO4
分子量433.95
EC 号212-019-3
MDL编号MFCD00078203
PubChem化学物质编号329750122
NACRESNA.24

产品性质

生物来源synthetic
等级pharmaceutical primary standard
agencyUSP
包装pkg of 200 mg
manufacturer/tradenameUSP
储存条件protect from light
颜色 white to off-white
pH值(酸碱度)3.5-5.5 (1% in aqueous solution, pH <6.0)
mp388.4 °F (198℃; 240℃)
溶解性chloroform: practically insoluble
ethanol: practically insoluble
ether: practically insoluble
water: soluble
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringOS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12
InChI1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
InChI keyJCBIVZZPXRZKTI-UHFFFAOYSA-N
Gene Informationhuman ... TLR7(51284), TLR9(54106)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H315 - H319
预防措施声明P301 + P312 + P330 - P305 + P351 + P338
危险分类Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
H0915Sigma-AldrichHydroxychloroquine Sulfate≥98% (HPLC), powder1501.21元/5 MG;   6306.89元/25 MG;   展开

产品说明

应用

硫酸羟氯喹已:

  • 用作自噬的抑制剂,以处理细胞进行凋亡测定用于研究吡柔比星在膀胱癌细胞系中诱导自噬的作用
  • 用于通过免疫荧光测定来评估羟氯喹对登革病毒-2 (DENV-2)感染的抗病毒机制
  • 用于抑制溶酶体与自噬体的融合

包装

5, 25 mg in glass bottle

生化/生理作用

羟氯喹也用于治疗类风湿性关节炎和系统性红斑狼疮。
硫酸羟氯喹是一种抗炎(通过肿瘤坏死因子)、疾病调节抗风湿药物(DMARD)和血红素聚合酶抑制剂。 它可用于治疗疟疾。

基本信息

经验(实验)分子式C18H26ClN3O · H2SO4
分子量433.95
EC 号212-019-3
MDL编号MFCD00078203
PubChem化学物质编号329815141
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
储存条件protect from light
颜色 white to off-white
溶解性H2O: >20 mg/mL
SMILES stringOS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12
InChI1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
InChI keyJCBIVZZPXRZKTI-UHFFFAOYSA-N
Gene Informationhuman ... TLR7(51284), TLR9(54106)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H315 - H319
预防措施声明P264 - P270 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
危险分类Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
H-157SupelcoHydroxychloroquine sulfate solution1 mg/mL (Methanol:Water (80:20) (v/v), (as free base)), certified reference material, ampule of 1 mL, Cerilliant®1400.61元/ampule of 1 mL;   展开

产品说明

一般描述

Hydroxychloroquine (HCQ), sold under the brand name Plaquenil among others, is a medication used to prevent and treat malaria in areas where malaria remains sensitive to chloroquine. Hydroxychloroquine is also being studied as a treatment for coronavirus disease. A Snap-N-Spike® reference solution applicable for use in pharma research and clinical toxicology analysis by LC-MS/MS or GC/MS.

法律信息

CERILLIANT is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Cerilliant Corporation

基本信息

经验(实验)分子式C18H26ClN3O · H2SO4
分子量433.95

产品性质

质量水平300
等级certified reference material
特点 Snap-N-Spike®/Snap-N-Shoot®
包装ampule of 1 mL
manufacturer/tradenameCerilliant®
浓度1 mg/mL (Methanol:Water (80:20) (v/v), (as free base))
格式single component solution
储存温度−20℃

安全信息

象形图GHS02GHS06GHS08
警示用语:Danger
危险声明H225 - H301 + H311 + H331 - H370
预防措施声明P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
危险分类Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
储存分类代码3 - Flammable liquids
WGKWGK 2
闪点(F)59.0 °F
闪点(C)15 ℃
BP1100Hydroxychloroquine SulfateBritish Pharmacopoeia (BP) Reference Standard1916.08元/100 MG;   展开

产品说明

一般描述

Hydroxychloroquine Sulfate (Hydroxychloroquine Sulphate) is a salt of hydroxychloroquine (HCQ, Plaquenil), a 4-aminoquinoline based antiviral drug.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Hydroxychloroquine Sulfate can be used as a pharmaceutical primary standard for the determination of the analyte in pharmaceutical formulations, and biological samples by various analytical techniques.

生化/生理作用

硫酸羟氯喹是一种抗炎(通过肿瘤坏死因子)、疾病调节抗风湿药物(DMARD)和血红素聚合酶抑制剂。 它可用于治疗疟疾。

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C18H26ClN3O · H2SO4
分子量433.95
MDL编号MFCD00078203

产品性质

等级pharmaceutical primary standard
agencyBP
形式solid
包装pkg of 100 mg
manufacturer/tradenameBP
颜色 off-white
mp238-241 ℃
溶解性water: soluble
application(s)pharmaceutical
格式neat
运输ambient
储存温度2-8℃
SMILES stringOS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12
InChI1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
InChI keyJCBIVZZPXRZKTI-UHFFFAOYSA-N
Gene Informationhuman ... TLR7(51284), TLR9(54106)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H315 - H319
预防措施声明P264 - P280 - P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338
危险分类Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
90527SupelcoHydroxychloroquine Sulfateanalytical standard869.57元/50 MG;   展开

产品说明

一般描述

硫酸羟氯喹(Hydroxychloroquine Sulphate)是羟氯喹(HCQ,赛能)的盐,它是一种4-氨基喹啉类抗病毒药物。

应用

硫酸羟氯喹可用作分析标准品,用于通过各种分析技术测定药物制剂 和生物样品 中的分析物。

生化/生理作用

硫酸羟氯喹是一种抗炎(通过肿瘤坏死因子)、疾病调节抗风湿药物(DMARD)和血红素聚合酶抑制剂。 它可用于治疗疟疾。

基本信息

经验(实验)分子式C18H26ClN3O · H2SO4
分子量433.95
EC 号212-019-3
MDL编号MFCD00078203
PubChem化学物质编号329769919
NACRESNA.24

产品性质

质量水平100
等级analytical standard
测定≥95.0% (HPLC)
保质期limited shelf life, expiry date on the label
包装pkg of 50 mg
technique(s)HPLC: suitable
gas chromatography (GC): suitable
杂质≤1.0% water
颜色 white to off-white
application(s)forensics and toxicology
pharmaceutical (small molecule)
veterinary
格式neat
储存温度2-8℃
SMILES stringOS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12
InChI1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
InChI keyJCBIVZZPXRZKTI-UHFFFAOYSA-N
Gene Informationhuman ... TLR7(51284), TLR9(54106)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H315 - H319
预防措施声明P264 - P270 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
危险分类Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
BP11012-[4-[(7-Chloro-4-quinolinyl)amino]pentyl] amino ethanolBritish Pharmacopoeia (BP) Reference Standard1989元/25 MG;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
2-[4-[(7-Chloro-4-quinolinyl)amino]pentyl] amino ethanol (Hydroxychloroquine Sulfate) is a salt of hydroxychloroquine (HCQ, Plaquenil), a 4-aminoquinoline based antiviral drug.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

2-[4-[(7-Chloro-4-quinolinyl)amino]pentyl] amino ethanol BP reference standard can be used as a pharmaceutical primary standard for the determination of the analyte in pharmaceutical formulations, and biological samples by various analytical techniques.

生化/生理作用

硫酸羟氯喹是一种抗炎(通过肿瘤坏死因子)、疾病调节抗风湿药物(DMARD)和血红素聚合酶抑制剂。 它可用于治疗疟疾。

包装

Unit quantity: 25 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C18H26ClN3O · H2SO4
分子量433.95
MDL编号MFCD00078203

产品性质

等级pharmaceutical primary standard
agencyBP
形式solid
包装pkg of 25 mg
manufacturer/tradenameBP
储存条件OK to freeze
颜色 off-white
mp238-241 ℃
溶解性water: soluble
application(s)pharmaceutical
格式neat
运输ambient
储存温度2-8℃
SMILES stringOS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12
InChI1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
InChI keyJCBIVZZPXRZKTI-UHFFFAOYSA-N
Gene Informationhuman ... TLR7(51284), TLR9(54106)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H315 - H319
预防措施声明P264 - P280 - P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338
危险分类Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
079411Fluorochem2-((4-((7-Chloroquinolin-4-yl)amino)pentyl)(ethyl)amino)ethanol sulfate95%220元/1g;   726元/5g;   1298元/10g;   2596元/25g;   展开

基本信息

CAS Number747-36-4
MDL NumberMFCD00078203
Melting Point240℃

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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