| CAS: | 732302-99-7 | |
| 分子式: | C24H27N3O4·HCl·H2O | |
| 分子量: | 475.97 | |
| 英文名称: |
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| 用途: | Givinostat (ITF2357)是一种有效的HDAC抑制剂，作用于玉米HD2， HD1B和HD1A，无细胞试验中IC50分别为10 nM， 7.5 nM和16 nM。Phase 2。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||||||||||||||||
| G872288 | MACKLIN | Givinostat (ITF2357) | 99% | 1214元/10mg; 3036元/50mg; 6376元/250mg; | 展开 | ||||||||||||||||||||||||||||||||||||||||||
储存：-20℃ 状态：粉末 | |||||||||||||||||||||||||||||||||||||||||||||||
| SML1772 | Sigma-Aldrich | Givinostat hydrochloride hydrate | ≥95% (HPLC) | 1955.32元/5 MG; 7893.05元/25 MG; | 展开 | ||||||||||||||||||||||||||||||||||||||||||
产品说明 应用 Givinostat hydrochloride hydrate has been used as a histone deacetylase inhibitor to test its effect on the human immunodeficiency virus reactivation in CD4+ T-cell model. 包装 5, 25 mg in glass bottle 生化/生理作用 Givinostat (ITF2357) is a hydroxamate HDAC inhibitor that inhibits class I and class II enzymes. Givinostat posseses a very promising activity profile in multiple myeloma and acute myelogenous leukemia in vitro and in vivo. Givinostat also has anti-inflammatory activity and inhibits the secretion of the tumor necrosis factor-alpha (TNF-α), IL-1, and IL-6. Givinostat has been in multiple Phase 2 studies for both inflammatory diseases (Duchenne Muscular Dystrophy , Juvenile arthritis, Polycythemia Vera) and blood cancers (myelomas and lymphomas). 基本信息
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