CAS 72509-76-3; 非洛地平; ethyl methyl (4RS)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4- dihydropyridine-3,5-dicarboxylate

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货号

品牌

产品名称

规格

包装、参考价格

详情

F793788

MACKLIN

非洛地平

10mM in DMSO

545元/1ml;

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储存：-20°C

F810243

MACKLIN

非洛地平

≥98.0%

98元/1g; 214元/5g; 739元/25g; 2026元/100g; 8998元/500g;

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储存：2~8°C
状态：白色到黄色到黄绿色固体

F0814

TCI

Felodipine

>98.0%(HPLC)(N)

890元/1G; 2990元/5G;

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基本信息

纯度/分析方法	>98.0%(HPLC)(N)
分子式/分子量	C₁₈H₁₉Cl₂NO₄ = 384.25
外观与形状(20℃)	固体
Reaxys-RN	4331472
PubChem物质ID	135727013
MDL编号	MFCD00868316

技术规格

Appearance	White to Light yellow powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(with Total Nitrogen)	min. 98.0 %
Melting point	142.0 to 146.0 ℃

物性(参考值)

熔点	144 ℃
水溶性	不溶
溶解性(易溶于)	丙酮,醇

安全信息

图形或危害标志
信号词	警告
危险性说明	H302 + H312 + H332 : 吞咽、皮肤接触或吸入有害。
防范说明	P501 : 将内装物/容器送到批准的废物处理厂处理。 P261 : 避免吸入粉尘/烟/气体/烟雾/蒸气/喷雾。 P270 : 使用本产品时不要进食、饮水或吸烟。 P271 : 只能在室外或通风良好之处使用。 P264 : 作业后彻底清洗皮肤。 P280 : 戴防护手套/穿防护服。 P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。 P301 + P312 + P330 : 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口。 P302 + P352 + P312 : 如皮肤沾染：用水充分清洗。如感觉不适，呼叫急救中心/医生。 P304 + P340 + P312 : 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。如感觉不适，呼叫急救中心/医生。

相关法规

RTECS#

US7968700

360407

J&K

Felodipine

98%, 一种选择性L型Ca2+通道阻滞剂

201元/1g; 802元/5G;

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基本信息

分子式	C₁₈H₁₉Cl₂NO₄
分子量	384.25
熔点	144-146
MDL编码	MFCD00868316
Beilstein	4331472

产品描述

Felodipine 是一种选择性L型Ca2+通道阻断剂，IC50为0.15 nM。

靶点（IC50 & Targe）

L-type calcium channel,0.15nM

与多种其他Ca2+通道阻断剂不同, Felodipine对心脏没有副作用，因为Felodipine选择特异性作用于与心肌组织相关的血管平滑肌。

体外研究

Felodipine显著放松KCl收缩的猪冠状动脉节段，IC50为0.15 nM，通过阻断Ca2+通道,比Nifedipine(IC50 为～8 nM)效果强50倍，比Verapamil(IC50为～65 nM)效果强430倍。[1] Felodipine作用于初级人类VSMC和肺成纤维细胞，显著诱导IL-6和IL-8转录和分泌，ED50分别为 5.8 nM和5.3 nM，而Propranolol或 Furosemide 不能影响这两种IL基因表达。[2] Felodipine作用于豚鼠回肠纵平滑肌(GPILSM)，阻断毒蕈碱性受体调节的(carbachol)Ca2+依赖性收缩，IC50为1.45 nM。[3] Felodipine为0.1 μM低浓度时，作用于大鼠内皮细胞，提高NOx产生, Ca2+依赖性NOS活性, 和eNOS蛋白。[4] Felodipine (10 μM) 降低p42/44分裂原活化蛋白激酶核易位和PDGF-BB刺激的Elk-1激活，导致人SMC增殖受抑制。[5] Felodipine 稍微抑制Cav3.2 T型Ca2+通道，IC50为6.8 μM。[6]

体内研究

Felodipine口服处理5/6肾脏消融大鼠，显著降低平均血压(BP)。[7] Felodipine作用于主动脉壁，通过阻断NF-κB激活, 和降低巨噬细胞显著降低收缩压(SBP), 血清胰岛素, 细胞内粘附分子-1(ICAM-1)和血管细胞黏附分子-1(VCAM-1)，导致血管炎症反应受调节。[8]

动物实验

Animal Models: 5/6肾脏消融的雄性Sprague-Dawley大鼠

Formulation: 溶于DMSO,在盐水中稀释

Dosages: 1 g/kg/day

Administration: 口服处理

(Only for Reference)

参考文献

[1] Johnson JD, et al. J Pharmacol Exp Ther, 1983, 226(2), 330-334.

[2] R?dler S, et al. J Mol Cell Cardiol, 1995, 27(10), 2295-2302.

[3] Yiu S, et al. J Med Chem, 1996, 39(23), 4576-4582.

[4] Ding Y, et al. Hypertension, 1998, 32(4), 718-723.

[5] Yang Z, et al. Cardiovasc Res, 2002, 53(1), 227-231.

[6] Perez-Reyes E, et al. J Pharmacol Exp Ther, 2009, 328(2), 6

安全信息

图形或危害标志
提示语	Warning
危险说明	H302 H312 H332
防范说明	P261 P271 P501
WGK	3
RTECS	US7968700

F0030000

Felodipine

European Pharmacopoeia (EP) Reference Standard

1277.32元/ ;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

L-type calcium channel blocker

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₁₈H₁₉NO₄Cl₂
分子量	384.25
MDL编号	MFCD00868316
PubChem化学物质编号	329799620
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	EDQM
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	CCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(Cl)c2Cl)C(=O)OC
InChI	1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
InChI key	RZTAMFZIAATZDJ-UHFFFAOYSA-N
Gene Information	human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779), NR3C2(4306)

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P301 + P312 + P330
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

F9677

Sigma-Aldrich

Felodipine

solid

1237.51元/5 MG; 5271.44元/25 MG;

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产品说明

一般描述

Felodipine is a dihydropyridine derivative. It has diuretic properties. Felodipine has high vascular selectivity. It is used to treat hypertension. Felodipine regulates chronic stable angina.

生化/生理作用

L-type calcium channel blocker

特点和优势

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式	C₁₈H₁₉NO₄Cl₂
分子量	384.25
MDL编号	MFCD00868316
PubChem化学物质编号	24278449

产品性质

质量水平	200
形式	solid
溶解性	DMSO: 20 mg/mL H₂O: insoluble
创始人	AstraZeneca
SMILES string	CCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(Cl)c2Cl)C(=O)OC
InChI	1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
InChI key	RZTAMFZIAATZDJ-UHFFFAOYSA-N
Gene Information	human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779), CACNA2D1(781), NR3C2(4306)

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P264 - P270 - P301 + P312 - P501
危险分类	Acute Tox. 4 Oral
储存分类代码	11 - Combustible Solids
WGK	WGK 3
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

1269389

USP

Felodipine

United States Pharmacopeia (USP) Reference Standard

3231.47元/300 MG;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

L-type calcium channel blocker

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₁₈H₁₉NO₄Cl₂
分子量	384.25
MDL编号	MFCD00868316
PubChem化学物质编号	329749833
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	USP
application(s)	pharmaceutical (small molecule)
格式	neat
SMILES string	CCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(Cl)c2Cl)C(=O)OC
InChI	1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
InChI key	RZTAMFZIAATZDJ-UHFFFAOYSA-N
Gene Information	human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779), NR3C2(4306)

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P301 + P312 + P330
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

BP777

Felodipine

British Pharmacopoeia (BP) Reference Standard

1916.08元/100 MG;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

L-type calcium channel blocker

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₁₈H₁₉NO₄Cl₂
分子量	384.25
MDL编号	MFCD00868316

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	BP
格式	neat
储存温度	2-8℃
SMILES string	CCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(Cl)c2Cl)C(=O)OC
InChI	1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
InChI key	RZTAMFZIAATZDJ-UHFFFAOYSA-N
Gene Information	human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779), NR3C2(4306)

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P264 - P270 - P301 + P312 - P501
危险分类	Acute Tox. 4 Oral
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

BP758

Felodipine impurity standard

British Pharmacopoeia (BP) Reference Standard

2978.17元/20 MG;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

L-type calcium channel blocker

包装

Unit quantity: 20 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₁₈H₁₉NO₄Cl₂
分子量	384.25
MDL编号	MFCD00868316

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	BP
格式	mixture
储存温度	2-8℃
SMILES string	CCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(Cl)c2Cl)C(=O)OC
InChI	1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
InChI key	RZTAMFZIAATZDJ-UHFFFAOYSA-N
Gene Information	human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779), NR3C2(4306)

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P264 - P270 - P301 + P312 + P330 - P501
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

M06306

Fluorochem

Felodipine

>99%

2068元/1g; 6842元/5g; 20636元/25g;

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基本信息

CAS Number	72509-76-3
MDL Number	MFCD00868316
Melting Point	144℃

安全信息

图形或危害标志
危险性说明	H302: Harmful if swallowed. H315: Causes skin irritation. H319: Causes serious eye irritation. H332: Harmful if inhaled. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P330: Rinse mouth. P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .