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CAS: 72214-67-6
分子式: C8H9Cl3N2S
分子量: 271.59
英文名称: 
rrd-251 hydrochloride
(2,4-dichlorophenyl)carbamimidothioic acid methyl ester hydrochloride
s-(2,4-dichlorobenzyl)-isothiouronium hydrochloride
rb/raf-1 disruptor 251 hydrochloride
2-(2,4-dichlorobenzyl)-2-thiopseudourea hydrochloride
推荐供应商
货号品牌产品名称规格包装、参考价格详情
D724996MACKLINS-2,4-二氯苄基 异硫脲 盐酸盐99%234元/50mg;   398元/100mg;   755元/250mg;   展开
储存:室温, 惰性气体
R7532Sigma-AldrichRRD-251 hydrochloride≥98% (HPLC)489.22元/5 MG;   2426.51元/25 MG;   展开

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction. The retinoblastoma tumor suppressor protein (Rb) controls the G1-S boundary by repressing the transcriptional activity of the E2F family of transcription factors. Raf-1 kinase binds and phosphorylates Rb early in the G1 phase. RRD-251 significantly inhibits angiogenesis and tumor growth in vivo in an Rb-dependent manner. RRD-251 does not inhibit the binding of B-Raf to Rb and Raf-1 to Mek1/2. Also, RRD-251 does not affect the kinase activities associated with cyclin D, cyclin E, or Raf-1.

基本信息

经验(实验)分子式C8H8Cl2N2S· HCl
分子量271.59
MDL编号MFCD00035047
PubChem化学物质编号329823647

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
储存条件desiccated
颜色 white to off-white
溶解性DMSO: >10 mg/mL
H2O: >2 mg/mL
储存温度room temp
SMILES stringCl.NC(=N)SCc1ccc(Cl)cc1Cl
InChI1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(7(10)3-6)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H
InChI keyCOMNQRICZGJVLE-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
391860Fluorochem2,4-dichlorobenzyl imidothiocarbamate hydrochloride95%4510元/1g;   15730元/5g;   展开

基本信息

CAS Number72214-67-6
MDL NumberMFCD00035047
CAS号首数字顺序排列: 1 2 3 4 5 6 7 8 9