产品说明 应用 Tocainide hydrochloride may be used in cell signaling studies. 包装 10, 50 mg in glass bottle 生化/生理作用 Tocainide hydrochloride is a primary amine analog of lidocaine (lignocaine), used for the treatment of tinnitus. It blocks the sodium channels in the pain-producing foci in the nerve membranes and renders an analgesic effect in trigeminal neuralgia.
Tocainide hydrochloride is a sodium channel blocker; Class IB antiarrhythmic. 特点和优势 This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Tocainide is voltage-dependent and use-dependent sodium channel blocker (class IB type antiarrhythmic); Ki = 115 μM in blockade of inactivated-state sodium channels; IC50 = 985μM in blockade of Na+ currents at a holding potential (HP) of -140 mV; IC50 = 254 μM in blockade of Na+ currents at HP -70 mV; IC50 = 523 μM in blockade of Na+ currents at tonic block (-100 mV); IC50 = 248 μM for use-dependent block at 10 Hz. 基本信息 | 经验(实验)分子式 | C11H16N2O · HCl | | 分子量 | 228.72 | | EC 号 | 275-361-2 | | MDL编号 | MFCD00941502 | | PubChem化学物质编号 | 24724626 | | NACRES | NA.77 |
产品性质 | 质量水平 | 100 | | 测定 | ≥98% (HPLC) | | 形式 | solid | | 储存条件 | desiccated
under inert gas | | 颜色 | white | | 溶解性 | DMSO: >20 mg/mL
H2O: ≥5 mg/mL | | 创始人 | AstraZeneca | | 储存温度 | 2-8℃ | | SMILES string | Cl[H].CC(N)C(=O)Nc1c(C)cccc1C | | InChI | 1S/C11H16N2O.ClH/c1-7-5-4-6-8(2)10(7)13-11(14)9(3)12;/h4-6,9H,12H2,1-3H3,(H,13,14);1H | | InChI key | AMZACPWEJDQXGW-UHFFFAOYSA-N | | Gene Information | human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335) |
安全信息 | 象形图 |  | | 警示用语： | Warning | | 危险声明 | H302 | | 危险分类 | Acute Tox. 4 Oral | | 储存分类代码 | 13 - Non Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable | | 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
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