| CAS: | 71203-35-5 | ||
| 分子式: | C22H21N3O3S | ||
| 分子量: | 407.49 | ||
| 沸点: | 622.9±65.0°C | ||
| 熔点: | 216 °C | ||
| 中文名称: |
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| 英文名称: |
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| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||||||||||||
| C873880 | MACKLIN | ML141 | 98% | 150元/1mg; 409元/5mg; 1881元/25mg; | 展开 | ||||||||||||||||||||||||||||||||||||||
储存：2-8°C 状态：白色到灰白色(固体) | |||||||||||||||||||||||||||||||||||||||||||
| C798180 | MACKLIN | ML141 | 10mM in DMSO | 280元/1ml; | 展开 | ||||||||||||||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||||||||||||||
| SML0407 | Sigma-Aldrich | ML 141 | ≥98% (HPLC) | 1476.5元/5 MG; 4776.54元/25 MG; | 展开 | ||||||||||||||||||||||||||||||||||||||
产品说明 应用 ML 141 已被用于：
包装 5, 25 mg in glass bottle 生化/生理作用 141 是 Rho 家族 gtp 酶 cdc42 的强效、选择性抑制剂。抑制酶活性的 IC 50 为 200 nM，对 Rho 家族成员 Rac、Ras 或 Rab 无活性。通过与神经 Wiskott-Aldrich 综合征蛋白 (N-WASP) 的直接结合，Cdc42 参与了肌动蛋白聚合的调控，随后可激活 Arp2/3 复合物。该复合物介导肌动蛋白聚合成分支网络，并调节重要功能包括细胞粘附、细胞骨架排列、吞噬作用和宿主-病原体相互作用、运动、迁移和膜蛋白运输。 特点和优势 该化合物出现在《受体分类和信号转导手册》 GTP 结合蛋白(低分子量) 页面。要浏览其他手册页， 单击此处 。 基本信息
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| 217708 | Sigma-Aldrich | Cdc42/Rac1 GTPase Inhibitor, ML141-Calbiochem | The Cdc42/Rac1 GTPase Inhibitor, ML141 controls the biological activity of Cdc42/Rac1 GTPase. This small molecule/inhibitor is primarily used for Membrane applications. | 2741.8元/25 MG; | 展开 | ||||||||||||||||||||||||||||||||||||||
产品说明 一般描述 A cell-permeable, allosteric, trisubstituted dihydropyrazolyl compound that acts as a potent, selective, reversible and non-competitive inhibitor of Cdc42 GTPases (IC50 = 0.2, 2.6 and 5.4 µM against nucleotide depleted Cdc42-wt, Cdc42-wt and Cdc42 activated mutant, respectively) with excellent selectivity over Rho family GTPases (IC50 >100 µM for Ras-wt, Ras activated mutant, Rab7-wt, Rab2a-wt, Rac1-wt and Rac1 activated mutant). Shown to efficiently block Cdc42 association with GTPγS and PAK-PBD, and decrease GTP-Cdc42 (>95%) and GTP-Rac1 (≥40%) contents in EGF-stimulated 3T3 cells, and inhibit Bradykinin (Cat. No. 05-23-0500)-induced filopodia formation in 3T3 cells at 10 µM. 包装 25 mg in Glass bottle 警告 Toxicity: Standard Handling (A) 重悬 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 其他说明 Hong, L., et al. 2012. J. Biol. Chem.in press. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息
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