CAS 70641-51-9; 3,5,9-trioxa-4-phosphaheptacosan-1-aminium, 4-hydroxy-7-methoxy-n,n,n-trimethyl

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CAS:

70641-51-9

分子式:

C27H58NO6P

分子量:

523.73

英文名称:

3,5,9-trioxa-4-phosphaheptacosan-1-aminium, 4-hydroxy-7-methoxy-n,n,n-trimethyl

inner salt, 4-oxide, (+-)-hydroxide

rac-1-octadecyl-2-methoxyglycero-3-phosphocholine

5,9-trioxa-4-phosphaheptacosan-1-aminium,4-hydroxy-7-methoxy-n,n,n-trimethyl-, hydroxide, inner salt

用途:

依地福新是一种合成烷基-赖氨磷脂，具有抗肿瘤活性。该化合物诱导多种癌细胞的凋亡。乙二胺嘧啶在细胞膜中积累，在细胞膜中改变脂质成分并诱导脂质筏和 Fas/CD95 死亡受体的共簇。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

E920944

MACKLIN

依地芬

≥95% (HPLC)

1411元/5mg;

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储存：−20°C
状态：固体

341207

Sigma-Aldrich

ET-18-OCH₃-CAS 70641-51-9-Calbiochem

A cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells.

1763.65元/5 MG;

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产品说明

一般描述

A cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells. Selectively inhibits phosphatidylinositol-specific phospholipase C (PI-PLC, IC₅₀ = 9.6 µM) but does not inhibit phosphatidylcholine-specific PLC or PLD. Inhibits protein kinase C from various leukemic cells. Also promotes rapid and selective apoptosis in human leukemic cells. Has strong antitumor and anticancer properties.
A cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells. Selectively inhibits phosphatidylinositol-specific phospholipase C (PI-PLC, IC₅₀ = 9.6 µM) but does not inhibit phosphatidylcholine-specific PLC or PLD. Promotes apoptosis in mitogen-activated, but not resting, T lymphocytes in a dose- and time-dependent manner. Also promotes rapid and selective apoptosis in human leukemic cells.

包装

5 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Target IC₅₀: 9.6 µM against phosphatidylinositol-specific phospholipase C (PI-PLC)
Reversible: yes
Primary Target
PI-PLC

注意

Material may form micelles in aqueous stock solutions, which may affect experimental results.

警告

Toxicity: Carcinogenic / Teratogenic (D)

重悬

Following reconstitution in ethanol, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous solution; reconstitute just prior to use.

其他说明

Harguindey, J., et al. 2000. Apoptosis5, 87.
Cabaner, C., et al. 1999. Br. J. Pharmacol. 127, 813.
Powis, G., and Phil, D. 1994. Cancer Metastasis Rev.13, 91.
Helfman, D., et al. 1993. Cancer Res. 53, 2955.
Mollinedo, F., et al. 1993. Biochem. Biophys. Res. Commun. 192, 603.
Powis, G., et al. 1992. Cancer Res.52, 2835.
Oishi, K., et al. 1988. Biochem. Biophys. Res. Commun.157, 1000.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₇H₅₈NO₆P
分子量	523.73
MDL编号	MFCD00135190

产品性质

质量水平	100
测定	≥95% (TLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze
颜色	white
溶解性	DMSO: 5 mg/mL ethanol: 5 mg/mL chloroform: 50 mg/mL water: soluble
运输	ambient
储存温度	−20℃
InChI	1S/C27H58NO6P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-23-32-25-27(31-5)26-34-35(29,30)33-24-22-28(2,3)4/h27H,6-26H2,1-5H3
InChI key	MHFRGQHAERHWKZ-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

SML0332

Sigma-Aldrich

Edelfosine

≥95% (HPLC)

1666.25元/5 MG; 5366.38元/25 MG;

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产品说明

一般描述

依地福新具有抗炎、抗自身免疫、抗寄生虫和抗病毒的特性。它通过细胞收缩和细胞膜扰乱来刺激红细胞衰亡。

应用

依地福新已用于治疗人肺癌 A549 细胞，并研究其对 Tuftelin 1(TUFT1)表达的影响。它还用于评估 MCF-7/M 细胞的细胞生长。

包装

5, 25 mg in glass bottle

生化/生理作用

依地福新是一种合成烷基-赖氨磷脂，具有抗肿瘤活性。该化合物诱导多种癌细胞的凋亡。乙二胺嘧啶在细胞膜中积累，在细胞膜中改变脂质成分并诱导脂质筏和 Fas/CD95 死亡受体的共簇。

特点和优势

这种化合物是激酶磷酸酶生物学研究的特色产品。点击此处发现更多特色激酶磷酸酶生物产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

基本信息

经验(实验)分子式	C₂₇H₅₈NO₆P
分子量	523.73
MDL编号	MFCD00135190
PubChem化学物质编号	329825337
NACRES	NA.77

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	powder
颜色	white to beige
溶解性	H₂O: 15 mg/mL (clear solution)
运输	wet ice
储存温度	−20℃
SMILES string	CCCCCCCCCCCCCCCCCCOCC(COP([O-])(=O)OCC[N+](C)(C)C)OC
InChI	1S/C27H58NO6P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-23-32-25-27(31-5)26-34-35(29,30)33-24-22-28(2,3)4/h27H,6-26H2,1-5H3
InChI key	MHFRGQHAERHWKZ-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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