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CAS: 577784-91-9
分子式: C19H15Cl2N3O2S2
分子量: 452.38
英文名称: 
rna polymerase iii inhibitor-cas 577784-91-9-calbiochem
ml-60218, n-[1-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl-1-methyl-1h-pyrazol-5-yl)]-2-chlorobenzenesulfonamide
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货号品牌产品名称规格包装、参考价格详情
R920768MACKLINRNA Polymerase III Inhibitor≥99%2500元/5mg;   展开
储存:2-8°C,干燥,密封
557403Sigma-AldrichRNA Polymerase III Inhibitor-CAS 577784-91-9-CalbiochemRNA Polymerase III Inhibitor, CAS 577784-91-9, is a cell-permeable inhibitor of RNA Polymerase III (IC₅₀ = 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively).5167.48元/10 MG;   展开

产品说明

一般描述

A cell-permeable indazolo-sulfonamide compound that displays broad-spectrum inhibitory activity against RNA Polymerase III (IC50 = 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. Also available as a 25 mM solution in DMSO (Cat. No. 557404).
A cell-permeable inhibitor of RNA polymerase III (RNA Pol III) (IC50 = 27 µM for human RNA Pol III and 32 µM for Saccharomyces cerevisiae RNA Pol III). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription.

包装

10 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Product does not compete with ATP.
Cell permeable: yes
Primary Target
activity against RNA Polymerase III
Reversible: no
Target IC50: 27 and 32 µM for Human and S. cerevisiae RNA Pol III

警告

Toxicity: Carcinogenic / Teratogenic (D)

制备说明

Slight warming may be necessary to achieve complete solubilization.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Wu, L., et al. 2003. Euk. Cell2, 256.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C19H15Cl2N3O2S2
分子量452.38

产品性质

质量水平100
测定≥95% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 off-white
溶解性DMSO: 15 mg/mL
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable
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