| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 |
| W864480 | MACKLIN | 醉茄素 A | 98%(HPLC) | 683元/1mg; 1322元/5mg; 3780元/25mg; | 展开 |
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| W796551 | MACKLIN | 醉茄素 A | 分析对照品, 98%(HPLC) | 3192元/10mg; | 展开 |
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| 562354 | J&K | Withaferin A | 98% | 1089元/1MG; 4247元/5MG; | 展开 |
基本信息 | 分子式 | C28H38O6 | | 分子量 | 470.60 | | 熔点 | 242 | | MDL编码 | MFCD01746239 | | 存储条件 | Store at 2-8℃ |
安全信息 |
| 681535 | Sigma-Aldrich | Withaferin A, Withania somnifera-CAS 5119-48-2-Calbiochem | A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. | 1903.37元/1 MG; 6319.29元/5 MG; | 展开 |
产品说明 一般描述 A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Potently inhibits angiogenesis both in vitro (IC50 = 12 nM against HUVEC proliferation) and in vivo (80% inhibition at 7 µg/kg/day in C57BL/6J mice, s.c.) and NF-κB activation (IC50 = 500 nM in TNF-α-induced endothelial cells) by targeting the ubiquitin-mediated proteasome pathway. At higher concentrations (~5 µM) also affects AP-1 transcription and induces cell death. 包装 1, 5 mg in Plastic ampoule
Packaged under inert gas 生化/生理作用 Cell permeable: yes
Primary Target
A steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties.
Target IC50: 12 nM against angiogenesis in vitro by inhibiting HUVEC proliferation
Product does not compete with ATP.
Reversible: no 警告 Toxicity: Carcinogenic / Teratogenic (D) 其他说明 Mohan, R., et al. 2004. Angiogenesis7, 115.
Jeyaprakasam, B., et al. 2003. Life Sci.74, 125.
Devi, P.U., et al. 1995. Cancer Lett.95, 189.
Kupchan, S.M., et al. 1969. J. Org. Chem.34, 3858. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息 | 经验(实验)分子式 | C28H38O6 | | 分子量 | 470.60 | | MDL编号 | MFCD10687098 |
产品性质 | 质量水平 | 100 | | 测定 | ≥94% (HPLC) | | 形式 | solid | | manufacturer/tradename | Calbiochem® | | 储存条件 | OK to freeze
protect from light | | 颜色 | white | | 溶解性 | DMSO: 10 mg/mL
ethanol: 5 mg/mL | | 运输 | ambient | | 储存温度 | 2-8℃ | | InChI | 1S/C28H38O6/c1-14-11-21(33-25(32)17(14)13-29)15(2)18-5-6-19-16-12-24-28(34-24)23(31)8-7-22(30)27(28,4)20(16)9-10-26(18,19)3/h7-8,15-16,18-21,23-24,29,31H,5-6,9-13H2,1-4H3/t15-,16-,18+,19-,20-,21+,23-,24+,26+,27-,28+/m0/s1 | | InChI key | DBRXOUCRJQVYJQ-CKNDUULBSA-N |
安全信息 | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | 438.8 °F | | 闪点(C) | 226 ℃ |
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| W4394 | Sigma-Aldrich | Withaferin A | ≥95% (HPLC) | 5845.24元/5 MG; | 展开 |
产品说明 应用 用醉茄素 A 处理 HEK293 细胞，研究其对囊性纤维化炎症的影响。 生化/生理作用 醉茄素 A 是从植物中分离得到的甾体内酯 。具有强大的抗炎属性，可抑制 NF-κ 的活化B 信号通路。醉茄素 A 的抗肿瘤活性是由于它能够通过结合膜联蛋白 II 和破坏 F 肌动蛋白交联来改变细胞骨架结构。醉茄素 A 通过与波形蛋白和肌动蛋白结合抑制血管生成。
对肿瘤细胞具有细胞毒性的甾体内酯。保护作用归因于抗脂质过氧化、抗氧化和解毒功能。 制备说明 醉茄素 A 在 1 mg/mL 甲醇中生成澄清、无色溶液。 基本信息 | 经验(实验)分子式 | C28H38O6 | | 分子量 | 470.60 | | MDL编号 | MFCD10687098 | | PubChem化学物质编号 | 329830709 | | NACRES | NA.77 |
产品性质 | 质量水平 | 200 | | 生物来源 | plant (Withania somnifera) | | 测定 | ≥95% (HPLC) | | 形式 | powder | | mp | 252-253 ℃ | | 官能团 | epoxy
ketone | | 运输 | ambient | | 储存温度 | 2-8℃ | | SMILES string | C[C@H]([C@H]1CC(C)=C(CO)C(=O)O1)[C@H]2CC[C@H]3[C@@H]4C[C@H]5O[C@]56[C@@H](O)C=CC(=O)[C@]6(C)[C@H]4CC[C@]23C | | InChI | 1S/C28H38O6/c1-14-11-21(33-25(32)17(14)13-29)15(2)18-5-6-19-16-12-24-28(34-24)23(31)8-7-22(30)27(28,4)20(16)9-10-26(18,19)3/h7-8,15-16,18-21,23-24,29,31H,5-6,9-13H2,1-4H3/t15-,16-,18+,19-,20-,21+,23-,24+,26+,27-,28+/m0/s1 | | InChI key | DBRXOUCRJQVYJQ-CKNDUULBSA-N |
安全信息 | 储存分类代码 | 13 - Non Combustible Solids | | WGK | WGK 3 | | 闪点(F) | 438.8 °F | | 闪点(C) | 226 ℃ |
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| PHL89824 | | Withaferin A | phyproof® Reference Substance | 8896.85元/10 MG; | 展开 |
产品说明 一般描述 This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG 法律信息 phyproof is a registered trademark of PhytoLab GmbH & Co. KG 基本信息 | 经验(实验)分子式 | C28H38O6 | | 分子量 | 470.60 | | MDL编号 | MFCD10687098 |
产品性质 | 等级 | primary reference standard | | 产品线 | phyproof® Reference Substance | | 测定 | ≥95.0% (HPLC) | | manufacturer/tradename | PhytoLab | | application(s) | food and beverages | | 格式 | neat | | 储存温度 | 2-8℃ | | SMILES string | C[C@H]([C@H]1CC(C)=C(CO)C(=O)O1)[C@H]2CC[C@H]3[C@@H]4C[C@H]5O[C@]56[C@@H](O)C=CC(=O)[C@]6(C)[C@H]4CC[C@]23C | | InChI | 1S/C28H38O6/c1-14-11-21(33-25(32)17(14)13-29)15(2)18-5-6-19-16-12-24-28(34-24)23(31)8-7-22(30)27(28,4)20(16)9-10-26(18,19)3/h7-8,15-16,18-21,23-24,29,31H,5-6,9-13H2,1-4H3/t15-,16-,18+,19-,20-,21+,23-,24+,26+,27-,28+/m0/s1 | | InChI key | DBRXOUCRJQVYJQ-CKNDUULBSA-N |
安全信息 | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | 438.8 °F | | 闪点(C) | 226 ℃ |
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| 89910 | Supelco | Withaferin A | analytical standard | 11407.5元/10 MG; | 展开 |
产品说明 应用 Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support. 包装 Bottomless glass bottle. Contents are inside inserted fused cone. 基本信息 | 经验(实验)分子式 | C28H38O6 | | 分子量 | 470.60 | | MDL编号 | MFCD10687098 | | PubChem化学物质编号 | 329769558 | | NACRES | NA.24 |
产品性质 | 等级 | analytical standard | | 质量水平 | 100 | | 测定 | ≥95.0% (HPLC) | | 保质期 | limited shelf life, expiry date on the label | | technique(s) | HPLC: suitable
gas chromatography (GC): suitable | | application(s) | food and beverages | | 格式 | neat | | 储存温度 | 2-8℃ | | SMILES string | C[C@H]([C@H]1CC(C)=C(CO)C(=O)O1)[C@H]2CC[C@H]3[C@@H]4C[C@H]5O[C@]56[C@@H](O)C=CC(=O)[C@]6(C)[C@H]4CC[C@]23C | | InChI | 1S/C28H38O6/c1-14-11-21(33-25(32)17(14)13-29)15(2)18-5-6-19-16-12-24-28(34-24)23(31)8-7-22(30)27(28,4)20(16)9-10-26(18,19)3/h7-8,15-16,18-21,23-24,29,31H,5-6,9-13H2,1-4H3/t15-,16-,18+,19-,20-,21+,23-,24+,26+,27-,28+/m0/s1 | | InChI key | DBRXOUCRJQVYJQ-CKNDUULBSA-N |
安全信息 | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | 438.8 °F | | 闪点(C) | 226 ℃ |
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