CAS 5003-48-5; 贝诺酯; 2-(Acetyloxyl)benzoic acid 4-(acetylamino)phenyl ester

CAS:

5003-48-5

分子式:

C14H15NO5

分子量:

313.32

沸点:

453.11°C (rough estimate)

熔点:

177-181 °C

中文名称:

贝诺酯

扑炎痛

苯乐来

2-乙酰氧基苯甲酸-4-乙酰氨基苯酯

扑热息痛乙酰水杨酸酯

盐酸贝尼地平

英文名称:

2-(Acetyloxyl)benzoic acid 4-(acetylamino)phenyl ester

Salicylic acid acetate 4'-hydroxyace-etanilide ester

p-Acetamidophe-nyl

salicylic acid, acetate, ester with 4'-hydroxyacetanilide

2-(acetyloxy)benzoic acid 4-(acetylamino)phenyl ester

2-acetoxy-4'-(acetamino)phenylbenzoate

4'-(acetamido)phenyl-2-acetoxybenzoate

aspirin acetaminophen ester

benoral

benorilate

benorilato

benortan

benorylate

2-(acetyloxy)-benzoic aci 4-(acetylamino)phenyl ester

fenasparate

p-acetamidophenyl acetylsalicylate

p-n-acetylaminophenylacetylsalicylate

salipran

to 125

win 11450

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性质描述:

白色结晶性粉末。熔点175-176℃。易溶于热醇，不溶于水。

生产方法:

由乙酰水杨酸经酰氯化生成乙酰水杨酰氯，再与对乙酰胺基苯酚缩合得到贝诺酯。

用途:

该品为阿司匹林与扑热息痛的酯化产物，系一新型的消炎、解热、镇痛、治疗风湿病的药物。不良反应较阿司匹林小，病人易于耐受。口服后在胃肠道不被水解，易吸收并迅速在血中达到有效浓度。主要用于类风湿性关节炎、急慢性风湿性关节炎、风湿痛、感冒发烧、头痛、手术后疼痛、神经痛等。不良反应有呕吐、消化不良及便秘。尚可见嗜睡、头晕、定向障碍。用量过大时，多数人可有耳鸣及耳聋。肝肾功能损害者慎用。阿司匹林过敏者禁用。小鼠口服LD50为2000mg/kg，大鼠口服为-10000mg/kg；小鼠腹腔注射LD50为1255mg/kg，大鼠为1830mg/kg。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

A827969

MACKLIN

4-acetamidophenyl 2-acetoxybenzoate

95%

68元/1g; 145元/5g; 503元/25g; 1539元/100g;

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储存：室温
状态：白色-几乎白色晶体-粉末
折射率：1.4500 (estimate)

A799497

MACKLIN

4-acetamidophenyl 2-acetoxybenzoate

98%

78元/1g; 156元/5g; 511元/25g;

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储存：室温

A794675

MACKLIN

4-acetamidophenyl 2-acetoxybenzoate

10mM in DMSO

463元/1ml;

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储存：-20°C

B4827

TCI

Benorilate

>98.0%(HPLC)(N)

490元/5G; 1650元/25G;

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基本信息

纯度/分析方法	>98.0%(HPLC)(N)
分子式/分子量	C₁₇H₁₅NO₅ = 313.31
外观与形状(20℃)	固体
Reaxys-RN	2166628
PubChem物质ID	253660794
Merck Index (14)	1045
MDL编号	MFCD00864257

技术规格

Appearance	White to Almost white powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(with Total Nitrogen)	min. 98.0 %
Melting point	178.0 to 182.0 ℃

物性(参考值)

熔点

180 ℃

安全信息

信号词	警告
危险性说明	H303 : 吞咽可能有害。
防范说明	P312 : 如感觉不适，呼叫急救中心/医生。

相关法规

RTECS#

VO0720000

C46596

Alfa Aesar

Benorylate

2071元/5g; 8805元/25g;

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基本信息

Ref#
46596

分子式
C17H15NO5

分子量
372.46

GHS危害和防范说明

GHS符号

Hazard Statements
H302
Harmful if swallowed.

Precautionary Statements
P301+P330+P331 P312 P264

241996

Fluorochem

4-Acetamidophenyl 2-Acetoxybenzoate

95%

220元/1g; 374元/5g; 616元/10g; 1254元/25g;

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基本信息

CAS Number	5003-48-5
MDL Number	MFCD00864257
Melting Point	180℃

安全信息

图形或危害标志
危险性说明	H302: Harmful if swallowed. H315: Causes skin irritation. H319: Causes serious eye irritation. H332: Harmful if inhaled. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P330: Rinse mouth. P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .